Reactome | PEA [extracellular region]

PEA [extracellular region]

Stable Identifier

R-ALL-391200

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

2-phenylethylamine

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Bos taurus)

- Signaling by GPCR (Bos taurus)
  - GPCR downstream signalling (Bos taurus)
    - G alpha (s) signalling events (Bos taurus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Bos taurus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Bos taurus)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Bos taurus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Bos taurus)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Bos taurus)
        
        PEA [extracellular region]
  - GPCR ligand binding (Bos taurus)
    - Class A/1 (Rhodopsin-like receptors) (Bos taurus)
      - Amine ligand-binding receptors (Bos taurus)
        
        Trace amine-associated receptors can bind trace amines (Bos taurus)
        
        PEA [extracellular region]
        
        Trace amine-associated receptor:PEA [plasma membrane] (Bos taurus)
        
        PEA [extracellular region]

Signal Transduction (Caenorhabditis elegans)

- Signaling by GPCR (Caenorhabditis elegans)
  - GPCR downstream signalling (Caenorhabditis elegans)
    - G alpha (s) signalling events (Caenorhabditis elegans)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Caenorhabditis elegans)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Caenorhabditis elegans)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Caenorhabditis elegans)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Caenorhabditis elegans)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Caenorhabditis elegans)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Caenorhabditis elegans)
        
        PEA [extracellular region]
  - GPCR ligand binding (Caenorhabditis elegans)
    - Class A/1 (Rhodopsin-like receptors) (Caenorhabditis elegans)
      - Amine ligand-binding receptors (Caenorhabditis elegans)
        
        Trace amine-associated receptors can bind trace amines (Caenorhabditis elegans)
        
        PEA [extracellular region]
        
        Trace amine-associated receptor:PEA [plasma membrane] (Caenorhabditis elegans)
        
        PEA [extracellular region]

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (s) signalling events (Homo sapiens)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]
      - Liganded Gs-activating GPCRs bind inactive heterotrimeric Gs (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]
      - The Ligand:GPCR:Gs complex dissociates (Homo sapiens)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Homo sapiens)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]
        
        Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)
        
        PEA [extracellular region]
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Amine ligand-binding receptors (Homo sapiens)
        
        Trace amine-associated receptors can bind trace amines (Homo sapiens)
        
        PEA [extracellular region]
        
        Trace amine-associated receptor:PEA [plasma membrane] (Homo sapiens)
        
        PEA [extracellular region]

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (s) signalling events (Mus musculus)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Mus musculus)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Mus musculus)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Mus musculus)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Mus musculus)
        
        PEA [extracellular region]
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Amine ligand-binding receptors (Mus musculus)
        
        Trace amine-associated receptors can bind trace amines (Mus musculus)
        
        PEA [extracellular region]
        
        Trace amine-associated receptor:PEA [plasma membrane] (Mus musculus)
        
        PEA [extracellular region]

Signal Transduction (Xenopus tropicalis)

- Signaling by GPCR (Xenopus tropicalis)
  - GPCR downstream signalling (Xenopus tropicalis)
    - G alpha (s) signalling events (Xenopus tropicalis)
      - Liganded Gs-activating GPCR acts as a GEF for Gs (Xenopus tropicalis)
        
        GPCR:ligand complexes that act on Gs:Heterotrimeric G-protein Gs (active) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Xenopus tropicalis)
        
        PEA [extracellular region]
        
        Ligand:GPCR complexes that activate Gs:Heterotrimeric G-protein Gs (inactive) [plasma membrane] (Xenopus tropicalis)
        
        Ligand:GPCR complexes that activate Gs [plasma membrane] (Xenopus tropicalis)
        
        Trace amine-associated receptor:PEA [plasma membrane] (Xenopus tropicalis)
        
        PEA [extracellular region]
  - GPCR ligand binding (Xenopus tropicalis)
    - Class A/1 (Rhodopsin-like receptors) (Xenopus tropicalis)
      - Amine ligand-binding receptors (Xenopus tropicalis)
        
        Trace amine-associated receptors can bind trace amines (Xenopus tropicalis)
        
        PEA [extracellular region]
        
        Trace amine-associated receptor:PEA [plasma membrane] (Xenopus tropicalis)
        
        PEA [extracellular region]

External Reference Information

External Reference

2-phenylethylamine [ChEBI:18397]

Participates

as an input of

as a member of

Ligands of GPCRs that activate Gs [extracellular region] (Homo sapiens)

as a component of

Other forms of this molecule

PEA [cytosol]

Cross References

Guide to Pharmacology - Ligands

2144

COMPOUND

C05332

PubChem Substance

8144848

HMDB Metabolite

HMDB0012275

ZINC

000006579654

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