Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
T4 [extracellular region]
Stable Identifier
R-ALL-352326
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Thyroxine, L-thyroxine, 3,5,3'5'-tetraiodothyronine
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Thyroxine biosynthesis (Bos taurus)
Two DITs combine to form thyroxine (Bos taurus)
T4 [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
SLC-mediated transport of organic anions (Bos taurus)
Organic anion transport by SLCO transporters (Bos taurus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Bos taurus)
SLCO3A1 substrates [extracellular region] (Bos taurus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Thyroxine biosynthesis (Caenorhabditis elegans)
Two DITs combine to form thyroxine (Caenorhabditis elegans)
T4 [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
SLC-mediated transport of organic anions (Caenorhabditis elegans)
Organic anion transport by SLCO transporters (Caenorhabditis elegans)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Thyroxine biosynthesis (Canis familiaris)
Two DITs combine to form thyroxine (Canis familiaris)
T4 [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
SLC-mediated transport of organic anions (Canis familiaris)
Organic anion transport by SLCO transporters (Canis familiaris)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Canis familiaris)
SLCO3A1 substrates [extracellular region] (Canis familiaris)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
SLC-mediated transport of organic anions (Danio rerio)
Organic anion transport by SLCO transporters (Danio rerio)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Danio rerio)
SLCO3A1 substrates [extracellular region] (Danio rerio)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Thyroxine biosynthesis (Drosophila melanogaster)
Two DITs combine to form thyroxine (Drosophila melanogaster)
T4 [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
SLC-mediated transport of organic anions (Drosophila melanogaster)
Organic anion transport by SLCO transporters (Drosophila melanogaster)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Thyroxine biosynthesis (Gallus gallus)
Two DITs combine to form thyroxine (Gallus gallus)
T4 [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
SLC-mediated transport of organic anions (Gallus gallus)
Organic anion transport by SLCO transporters (Gallus gallus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Gallus gallus)
SLCO3A1 substrates [extracellular region] (Gallus gallus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Two DITs combine to form thyroxine (Homo sapiens)
T4 [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
SLC-mediated transport of organic anions (Homo sapiens)
Organic anion transport by SLCO transporters (Homo sapiens)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Homo sapiens)
SLCO3A1 substrates [extracellular region] (Homo sapiens)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Thyroxine biosynthesis (Mus musculus)
Two DITs combine to form thyroxine (Mus musculus)
T4 [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
SLC-mediated transport of organic anions (Mus musculus)
Organic anion transport by SLCO transporters (Mus musculus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Mus musculus)
SLCO3A1 substrates [extracellular region] (Mus musculus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of amine-derived hormones (Rattus norvegicus)
Thyroxine biosynthesis (Rattus norvegicus)
Two DITs combine to form thyroxine (Rattus norvegicus)
T4 [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
SLC-mediated transport of organic anions (Rattus norvegicus)
Organic anion transport by SLCO transporters (Rattus norvegicus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Rattus norvegicus)
SLCO3A1 substrates [extracellular region] (Rattus norvegicus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
SLC-mediated transport of organic anions (Saccharomyces cerevisiae)
Organic anion transport by SLCO transporters (Saccharomyces cerevisiae)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of amine-derived hormones (Sus scrofa)
Thyroxine biosynthesis (Sus scrofa)
Two DITs combine to form thyroxine (Sus scrofa)
T4 [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
SLC-mediated transport of organic anions (Sus scrofa)
Organic anion transport by SLCO transporters (Sus scrofa)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has a broad substrate specificity (Sus scrofa)
SLCO3A1 substrates [extracellular region] (Sus scrofa)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Metabolism of amine-derived hormones (Xenopus tropicalis)
Thyroxine biosynthesis (Xenopus tropicalis)
Two DITs combine to form thyroxine (Xenopus tropicalis)
T4 [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
SLC-mediated transport of organic anions (Xenopus tropicalis)
Organic anion transport by SLCO transporters (Xenopus tropicalis)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
T3,T4 [extracellular region]
T4 [extracellular region]
External Reference Information
External Reference
L-thyroxine zwitterion [ChEBI:58448]
Participates
as a member of
SLCO3A1 substrates [extracellular region] (Gallus gallus)
SLCO3A1 substrates [extracellular region] (Sus scrofa)
SLCO3A1 substrates [extracellular region] (Bos taurus)
SLCO3A1 substrates [extracellular region] (Mus musculus)
SLCO3A1 substrates [extracellular region] (Xenopus tropicalis)
SLCO3A1 substrates [extracellular region] (Danio rerio)
SLCO3A1 substrates [extracellular region] (Canis familiaris)
SLCO3A1 substrates [extracellular region] (Rattus norvegicus)
SLCO3A1 substrates [extracellular region] (Homo sapiens)
T3,T4 [extracellular region]
as an output of
Two DITs combine to form thyroxine (Caenorhabditis elegans)
Two DITs combine to form thyroxine (Drosophila melanogaster)
Two DITs combine to form thyroxine (Gallus gallus)
Two DITs combine to form thyroxine (Xenopus tropicalis)
Two DITs combine to form thyroxine (Sus scrofa)
Two DITs combine to form thyroxine (Bos taurus)
Two DITs combine to form thyroxine (Canis familiaris)
Two DITs combine to form thyroxine (Rattus norvegicus)
Two DITs combine to form thyroxine (Mus musculus)
Two DITs combine to form thyroxine (Homo sapiens)
Other forms of this molecule
T4 [cytosol]
Cross References
COMPOUND
C01829
ZINC
ZINC000003830993
© 2026
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![T4 [extracellular region] icon](/icon/R-ICO-014829.svg){kind=icon}
