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T4 [extracellular region]
Stable Identifier
R-ALL-352326
Type
Chemical Compound [SimpleEntity]
Compartment
extracellular region
Synonyms
Thyroxine, L-thyroxine, 3,5,3'5'-tetraiodothyronine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Thyroxine biosynthesis (Bos taurus)
Two DITs combine to form thyroxine (Bos taurus)
T4 [extracellular region]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of vitamins, nucleosides, and related molecules (Bos taurus)
Transport of organic anions (Bos taurus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Bos taurus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Bos taurus)
SLCO3A1 substrates [extracellular region] (Bos taurus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Bos taurus)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Thyroxine biosynthesis (Caenorhabditis elegans)
Two DITs combine to form thyroxine (Caenorhabditis elegans)
T4 [extracellular region]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of vitamins, nucleosides, and related molecules (Caenorhabditis elegans)
Transport of organic anions (Caenorhabditis elegans)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Caenorhabditis elegans)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Thyroxine biosynthesis (Canis familiaris)
Two DITs combine to form thyroxine (Canis familiaris)
T4 [extracellular region]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of vitamins, nucleosides, and related molecules (Canis familiaris)
Transport of organic anions (Canis familiaris)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Canis familiaris)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Canis familiaris)
SLCO3A1 substrates [extracellular region] (Canis familiaris)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Canis familiaris)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of vitamins, nucleosides, and related molecules (Danio rerio)
Transport of organic anions (Danio rerio)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Danio rerio)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Danio rerio)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Thyroxine biosynthesis (Dictyostelium discoideum)
Two DITs combine to form thyroxine (Dictyostelium discoideum)
T4 [extracellular region]
Transport of small molecules (Dictyostelium discoideum)
SLC-mediated transmembrane transport (Dictyostelium discoideum)
Transport of vitamins, nucleosides, and related molecules (Dictyostelium discoideum)
Transport of organic anions (Dictyostelium discoideum)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Dictyostelium discoideum)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Thyroxine biosynthesis (Drosophila melanogaster)
Two DITs combine to form thyroxine (Drosophila melanogaster)
T4 [extracellular region]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of vitamins, nucleosides, and related molecules (Drosophila melanogaster)
Transport of organic anions (Drosophila melanogaster)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Drosophila melanogaster)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Thyroxine biosynthesis (Gallus gallus)
Two DITs combine to form thyroxine (Gallus gallus)
T4 [extracellular region]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of vitamins, nucleosides, and related molecules (Gallus gallus)
Transport of organic anions (Gallus gallus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Gallus gallus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Gallus gallus)
SLCO3A1 substrates [extracellular region] (Gallus gallus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Gallus gallus)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Thyroxine biosynthesis (Homo sapiens)
Two DITs combine to form thyroxine (Homo sapiens)
T4 [extracellular region]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of vitamins, nucleosides, and related molecules (Homo sapiens)
Transport of organic anions (Homo sapiens)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Homo sapiens)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Homo sapiens)
SLCO3A1 substrates [extracellular region] (Homo sapiens)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Homo sapiens)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Thyroxine biosynthesis (Mus musculus)
Two DITs combine to form thyroxine (Mus musculus)
T4 [extracellular region]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of vitamins, nucleosides, and related molecules (Mus musculus)
Transport of organic anions (Mus musculus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Mus musculus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Mus musculus)
SLCO3A1 substrates [extracellular region] (Mus musculus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Mus musculus)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Plasmodium falciparum)
SLC-mediated transmembrane transport (Plasmodium falciparum)
Transport of vitamins, nucleosides, and related molecules (Plasmodium falciparum)
Transport of organic anions (Plasmodium falciparum)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Plasmodium falciparum)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of amine-derived hormones (Rattus norvegicus)
Thyroxine biosynthesis (Rattus norvegicus)
Two DITs combine to form thyroxine (Rattus norvegicus)
T4 [extracellular region]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of vitamins, nucleosides, and related molecules (Rattus norvegicus)
Transport of organic anions (Rattus norvegicus)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Rattus norvegicus)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Rattus norvegicus)
SLCO3A1 substrates [extracellular region] (Rattus norvegicus)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Rattus norvegicus)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Saccharomyces cerevisiae)
SLC-mediated transmembrane transport (Saccharomyces cerevisiae)
Transport of vitamins, nucleosides, and related molecules (Saccharomyces cerevisiae)
Transport of organic anions (Saccharomyces cerevisiae)
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Saccharomyces cerevisiae)
T3,T4 [extracellular region]
T4 [extracellular region]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of amine-derived hormones (Sus scrofa)
Thyroxine biosynthesis (Sus scrofa)
Two DITs combine to form thyroxine (Sus scrofa)
T4 [extracellular region]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of vitamins, nucleosides, and related molecules (Sus scrofa)
Transport of organic anions (Sus scrofa)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Sus scrofa)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCO3A1 isoform 1 has abroad substrate specificity (Sus scrofa)
SLCO3A1 substrates [extracellular region] (Sus scrofa)
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Sus scrofa)
T3,T4 [extracellular region]
T4 [extracellular region]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of vitamins, nucleosides, and related molecules (Xenopus tropicalis)
Transport of organic anions (Xenopus tropicalis)
SLCO1B1 transports T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
T3,T4 [extracellular region]
T4 [extracellular region]
SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol (Xenopus tropicalis)
T3,T4 [extracellular region]
T4 [extracellular region]
External Reference Information
External Reference
L-thyroxine [ChEBI:18332]
Participates
as a member of
SLCO3A1 substrates [extracellular region] (Rattus norvegicus)
SLCO3A1 substrates [extracellular region] (Sus scrofa)
SLCO3A1 substrates [extracellular region] (Bos taurus)
SLCO3A1 substrates [extracellular region] (Canis familiaris)
SLCO3A1 substrates [extracellular region] (Xenopus tropicalis)
SLCO3A1 substrates [extracellular region] (Mus musculus)
SLCO3A1 substrates [extracellular region] (Danio rerio)
SLCO3A1 substrates [extracellular region] (Gallus gallus)
SLCO3A1 substrates [extracellular region] (Homo sapiens)
T3,T4 [extracellular region]
as an output of
Two DITs combine to form thyroxine (Dictyostelium discoideum)
Two DITs combine to form thyroxine (Caenorhabditis elegans)
Two DITs combine to form thyroxine (Drosophila melanogaster)
Two DITs combine to form thyroxine (Gallus gallus)
Two DITs combine to form thyroxine (Sus scrofa)
Two DITs combine to form thyroxine (Bos taurus)
Two DITs combine to form thyroxine (Rattus norvegicus)
Two DITs combine to form thyroxine (Mus musculus)
Two DITs combine to form thyroxine (Homo sapiens)
Two DITs combine to form thyroxine (Canis familiaris)
Other forms of this molecule
T4 [cytosol]
Cross References
Guide to Pharmacology - Ligands
2635
COMPOUND
C01829
HMDB Metabolite
HMDB0000248
ZINC
ZINC000003830993
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