Reactome | 12(S)-HETE [extracellular region]

12(S)-HETE [extracellular region]

Stable Identifier

R-ALL-3296298

Type

Chemical Compound [SimpleEntity]

Compartment

extracellular region

Synonyms

12(S)-HETE(1-)

Locations in the PathwayBrowser

for Species:

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Signal Transduction (Canis familiaris)

- Signaling by GPCR (Canis familiaris)
  - GPCR downstream signalling (Canis familiaris)
    - G alpha (i) signalling events (Canis familiaris)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Canis familiaris)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Canis familiaris)
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]
  - GPCR ligand binding (Canis familiaris)
    - Class A/1 (Rhodopsin-like receptors) (Canis familiaris)
      - Free fatty acid receptors (Canis familiaris)
        
        GPR31 is a receptor for 12(S)-HETE (Canis familiaris)
        
        12(S)-HETE [extracellular region]
        
        GPR31:12(S)-HETE [plasma membrane] (Canis familiaris)
        
        12(S)-HETE [extracellular region]

Signal Transduction (Danio rerio)

- Signaling by GPCR (Danio rerio)
  - GPCR downstream signalling (Danio rerio)
    - G alpha (i) signalling events (Danio rerio)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
        
        GPR31:12(S)-HETE [plasma membrane] (Danio rerio)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Danio rerio)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Danio rerio)
        
        GPR31:12(S)-HETE [plasma membrane] (Danio rerio)
        
        12(S)-HETE [extracellular region]

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Free fatty acid receptors (Homo sapiens)
        
        GPR31 is a receptor for 12(S)-HETE (Homo sapiens)
        
        12(S)-HETE [extracellular region]
        
        GPR31:12(S)-HETE [plasma membrane] (Homo sapiens)
        
        12(S)-HETE [extracellular region]

Signal Transduction (Mus musculus)

- Signaling by GPCR (Mus musculus)
  - GPCR downstream signalling (Mus musculus)
    - G alpha (i) signalling events (Mus musculus)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
      - The Ligand:GPCR:Gi complex dissociates (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Mus musculus)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Mus musculus)
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]
  - GPCR ligand binding (Mus musculus)
    - Class A/1 (Rhodopsin-like receptors) (Mus musculus)
      - Free fatty acid receptors (Mus musculus)
        
        GPR31 is a receptor for 12(S)-HETE (Mus musculus)
        
        12(S)-HETE [extracellular region]
        
        GPR31:12(S)-HETE [plasma membrane] (Mus musculus)
        
        12(S)-HETE [extracellular region]

External Reference Information

External Reference

12(S)-HETE(1-) [ChEBI:90680]

Participates

as an input of

as a component of

Other forms of this molecule

12S-HETE [cytosol]

Cross References

ZINC

000004655428

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