GDC0941

Stable Identifier
R-ALL-2399804
Type
ChemicalDrug
Compartment
Synonyms
pictrelisib
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
18754654 The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer

Folkes, AJ, Ahmadi, K, Alderton, WK, Alix, S, Baker, SJ, Box, G, Chuckowree, IS, Clarke, PA, Depledge, P, Eccles, SA, Friedman, LS, Hayes, A, Hancox, TC, Kugendradas, A, Lensun, L, Moore, P, Olivero, AG, Pang, J, Patel, S, Pergl-Wilson, GH, Raynaud, FI, Robson, A, Saghir, N, Salphati, L, Sohal, S, Ultsch, MH, Valenti, M, Wallweber, HJ, Wan, NC, Wiesmann, C, Workman, P, Zhyvoloup, A, Zvelebil, MJ, Shuttleworth, SJ

J. Med. Chem. 2008
19411071 Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941

Junttila, TT, Akita, RW, Parsons, K, Fields, C, Lewis Phillips, GD, Friedman, LS, Sampath, D, Sliwkowski, MX

Cancer Cell 2009
Participant Of
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI