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SU5402 [cytosol]
Stable Identifier
R-ALL-2054052
Type
ChemicalDrug
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by FGFR1 amplification mutants (Homo sapiens)
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
SU5402 [cytosol]
Overexpressed FGFR1:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
SU5402 [cytosol]
Signaling by cytosolic FGFR1 fusion mutants (Homo sapiens)
Tyrosine kinase inhibitors bind and inhibit cytosolic FGFR1 fusion dimer phosphorylation (Homo sapiens)
Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol]
SU5402 [cytosol]
FGFR1 fusion mutant dimers:TKIs [cytosol] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol]
SU5402 [cytosol]
Signaling by FGFR2 in disease (Homo sapiens)
FGFR2 mutant receptor activation (Homo sapiens)
Activated point mutants of FGFR2 (Homo sapiens)
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
SU5402 [cytosol]
FGFR2 point mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
SU5402 [cytosol]
Signaling by FGFR3 in disease (Homo sapiens)
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
SU5402 [cytosol]
FGFR3 mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
SU5402 [cytosol]
General
SU5402 is an ATP-competitive FGFR and VEGFR inhibitor that is used as an in vitro reagent. Su5402 is not suitable for therapeutic use due to toxicity issues.
Literature References
PubMed ID
Title
Journal
Year
15116089
Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
Holbro, T
,
Hynes, NE
,
Koziczak, M
Oncogene
2004
External Reference Information
External Reference
SU5402 [PubChem Compound:5289418]
Participates
as a member of
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
63449
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