Tyrosine kinase inhibitors of FGFR1 fusion mutants [cytosol]

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R-ALL-2045079
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Literature References
PubMed ID Title Journal Year
11739186 The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins

Demiroglu, A, Steer, EJ, Heath, C, Taylor, K, Bentley, M, Allen, SL, Koduru, P, Brody, JP, Hawson, G, Rodwell, R, Doody, ML, Carnicero, F, Reiter, A, Goldman, JM, Melo, JV, Cross, NC

Blood 2001
16946300 Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia

Gu, TL, Goss, VL, Reeves, C, Popova, L, Nardone, J, Macneill, J, Walters, DK, Wang, Y, Rush, J, Comb, MJ, Druker, BJ, Polakiewicz, RD

Blood 2006
17698633 Activity of TKI258 against primary cells and cell lines with FGFR1 fusion genes associated with the 8p11 myeloproliferative syndrome

Chase, A, Grand, FH, Cross, NC

Blood 2007
15448205 PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

Chen, J, Deangelo, DJ, Kutok, JL, Williams, IR, Lee, BH, Wadleigh, M, Duclos, N, Cohen, S, Adelsperger, J, Okabe, R, Coburn, A, Galinsky, I, Huntly, B, Cohen, PS, Meyer, T, Fabbro, D, Roesel, J, Banerji, L, Griffin, JD, Xiao, S, Fletcher, JA, Stone, RM, Gilliland, DG

Proc Natl Acad Sci U S A 2004
17533378 Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK

Zhen, Y, Sørensen, V, Jin, Y, Suo, Z, Wied?ocha, A

Oncogene 2007
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