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BGJ398 [cytosol]
Stable Identifier
R-ALL-2038925
Type
ChemicalDrug
Compartment
cytosol
Synonyms
BGJ-398
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by FGFR in disease (Homo sapiens)
Signaling by FGFR1 in disease (Homo sapiens)
FGFR1 mutant receptor activation (Homo sapiens)
Signaling by FGFR1 amplification mutants (Homo sapiens)
Tyrosine kinase inhibitors bind and inhibit overexpressed FGFR1 dimers (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
BGJ398 [cytosol]
Overexpressed FGFR1:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
BGJ398 [cytosol]
Signaling by FGFR2 in disease (Homo sapiens)
FGFR2 mutant receptor activation (Homo sapiens)
Activated point mutants of FGFR2 (Homo sapiens)
Point mutants of FGFR2 bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
BGJ398 [cytosol]
FGFR2 point mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
BGJ398 [cytosol]
Signaling by FGFR2 amplification mutants (Homo sapiens)
Tyrosine kinase inhibitors bind to overexpressed FGFR2 variants (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
BGJ398 [cytosol]
Overexpressed FGFR2:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
BGJ398 [cytosol]
Signaling by FGFR3 in disease (Homo sapiens)
FGFR3 mutants bind and are inactivated by tyrosine kinase inhibitors (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
BGJ398 [cytosol]
FGFR3 mutant dimers:TKIs [plasma membrane] (Homo sapiens)
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
BGJ398 [cytosol]
General
A pan-FGFR ATP-competitive inhibitor that is in phase I clinical trials for advanced solid malignancies with amplification or activation of FGFR1 and 2 or activation of FGFR3 (NCT01004224).
External Reference Information
External Reference
BGJ-398 [Guide to Pharmacology:7877]
Participates
as a member of
Tyrosine kinase inhibitors of overexpressed FGFR2 [cytosol]
Tyrosine kinase inhibitors of FGFR2 mutants [cytosol]
Tyrosine kinase inhibitors of FGFR3 mutants [cytosol]
Tyrosine kinase inhibitors of overexpressed FGFR1 [cytosol]
Disease
Name
Identifier
Synonyms
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
ChEBI
63451
Pharos - Ligands
51D1WX9A6P18
PharmacoDB
PDBC37455
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