Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
5-methyl-THF [cytosol]
Stable Identifier
R-ALL-200665
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
5-methyltetrahydrofolate, 5-methyltetrahydrofolic acid, 5-methyltetrahydrofolate(2-), (6S)-5-methyltetrahydrofolate(2-)
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of vitamins and cofactors (Bos taurus)
Metabolism of water-soluble vitamins and cofactors (Bos taurus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Bos taurus)
Cobalamin (Cbl) metabolism (Bos taurus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Bos taurus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)
5-methyl-THF [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of vitamins and cofactors (Caenorhabditis elegans)
Metabolism of water-soluble vitamins and cofactors (Caenorhabditis elegans)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Caenorhabditis elegans)
Cobalamin (Cbl) metabolism (Caenorhabditis elegans)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)
5-methyl-THF [cytosol]
Metabolism (Canis familiaris)
Metabolism of vitamins and cofactors (Canis familiaris)
Metabolism of water-soluble vitamins and cofactors (Canis familiaris)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Canis familiaris)
Cobalamin (Cbl) metabolism (Canis familiaris)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Canis familiaris)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)
5-methyl-THF [cytosol]
Metabolism (Danio rerio)
Metabolism of vitamins and cofactors (Danio rerio)
Metabolism of water-soluble vitamins and cofactors (Danio rerio)
Metabolism of folate and pterines (Danio rerio)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)
5-methyl-THF [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of vitamins and cofactors (Dictyostelium discoideum)
Metabolism of water-soluble vitamins and cofactors (Dictyostelium discoideum)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Dictyostelium discoideum)
Cobalamin (Cbl) metabolism (Dictyostelium discoideum)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Dictyostelium discoideum)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)
5-methyl-THF [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of vitamins and cofactors (Drosophila melanogaster)
Metabolism of water-soluble vitamins and cofactors (Drosophila melanogaster)
Metabolism of folate and pterines (Drosophila melanogaster)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)
5-methyl-THF [cytosol]
Metabolism (Gallus gallus)
Metabolism of vitamins and cofactors (Gallus gallus)
Metabolism of water-soluble vitamins and cofactors (Gallus gallus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Gallus gallus)
Cobalamin (Cbl) metabolism (Gallus gallus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Gallus gallus)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Gallus gallus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Gallus gallus)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Gallus gallus)
5-methyl-THF [cytosol]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Defects in vitamin and cofactor metabolism (Homo sapiens)
Defects in cobalamin (B12) metabolism (Homo sapiens)
Defective MTR causes HMAG (Homo sapiens)
Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)
5-methyl-THF [cytosol]
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)
5-methyl-THF [cytosol]
Metabolism (Mus musculus)
Metabolism of vitamins and cofactors (Mus musculus)
Metabolism of water-soluble vitamins and cofactors (Mus musculus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Mus musculus)
Cobalamin (Cbl) metabolism (Mus musculus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Mus musculus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)
5-methyl-THF [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of vitamins and cofactors (Rattus norvegicus)
Metabolism of water-soluble vitamins and cofactors (Rattus norvegicus)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Rattus norvegicus)
Cobalamin (Cbl) metabolism (Rattus norvegicus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Rattus norvegicus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)
5-methyl-THF [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of water-soluble vitamins and cofactors (Saccharomyces cerevisiae)
Metabolism of folate and pterines (Saccharomyces cerevisiae)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)
5-methyl-THF [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of water-soluble vitamins and cofactors (Schizosaccharomyces pombe)
Metabolism of folate and pterines (Schizosaccharomyces pombe)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)
5-methyl-THF [cytosol]
Metabolism (Sus scrofa)
Metabolism of vitamins and cofactors (Sus scrofa)
Metabolism of water-soluble vitamins and cofactors (Sus scrofa)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Sus scrofa)
Cobalamin (Cbl) metabolism (Sus scrofa)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)
5-methyl-THF [cytosol]
Metabolism of folate and pterines (Sus scrofa)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)
5-methyl-THF [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of vitamins and cofactors (Xenopus tropicalis)
Metabolism of water-soluble vitamins and cofactors (Xenopus tropicalis)
Metabolism of folate and pterines (Xenopus tropicalis)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)
5-methyl-THF [cytosol]
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)
5-methyl-THF [cytosol]
External Reference Information
External Reference
(6S)-5-methyltetrahydrofolate(2-) [ChEBI:18608]
Participates
as an input of
Defective MTR does not transfer CH3 group from MTHF to cob(I)alamin (Homo sapiens)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Dictyostelium discoideum)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Caenorhabditis elegans)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Gallus gallus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Sus scrofa)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Bos taurus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Canis familiaris)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Rattus norvegicus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Mus musculus)
MTR transfers CH3 group from 5-methyl-THF to cob(I)alamin (Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Saccharomyces cerevisiae)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Schizosaccharomyces pombe)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Dictyostelium discoideum)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Caenorhabditis elegans)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Drosophila melanogaster)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Gallus gallus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Xenopus tropicalis)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Danio rerio)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Sus scrofa)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Canis familiaris)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Rattus norvegicus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Mus musculus)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Homo sapiens)
FPGS-2 transforms 5-methyl-THF to 5-methyl-THFPG (Bos taurus)
as an output of
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Dictyostelium discoideum)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Caenorhabditis elegans)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Drosophila melanogaster)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Gallus gallus)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Xenopus tropicalis)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Danio rerio)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Sus scrofa)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Canis familiaris)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Rattus norvegicus)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Mus musculus)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Homo sapiens)
SLC19A1 transports 5-methyl-THF from extracellular region to cytosol (Bos taurus)
Other forms of this molecule
5-methyl-THF [extracellular region]
Cross References
ZINC
ZINC000002005305
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text