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Go!
CORT [cytosol]
Stable Identifier
R-ALL-193977
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
cortisol
Icon
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Canis familiaris
Danio rerio
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Cellular responses to stimuli (Bos taurus)
Cellular responses to stress (Bos taurus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Bos taurus)
ATP hydrolysis by HSP90 (Bos taurus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Bos taurus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Bos taurus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Bos taurus)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
NR3C2:NR3C2 ligands [cytosol] (Bos taurus)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Metabolism of steroids (Bos taurus)
Metabolism of steroid hormones (Bos taurus)
Glucocorticoid biosynthesis (Bos taurus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
CORT [cytosol]
Cellular responses to stimuli (Canis familiaris)
Cellular responses to stress (Canis familiaris)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Canis familiaris)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Canis familiaris)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Canis familiaris)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
NR3C2:NR3C2 ligands [cytosol] (Canis familiaris)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Metabolism of steroids (Canis familiaris)
Metabolism of steroid hormones (Canis familiaris)
Glucocorticoid biosynthesis (Canis familiaris)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
CORT [cytosol]
Cellular responses to stimuli (Danio rerio)
Cellular responses to stress (Danio rerio)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Danio rerio)
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Danio rerio)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Danio rerio)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
NR3C2:NR3C2 ligands [cytosol] (Danio rerio)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Metabolism of steroids (Danio rerio)
Metabolism of steroid hormones (Danio rerio)
Glucocorticoid biosynthesis (Danio rerio)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
CORT [cytosol]
Cellular responses to stimuli (Drosophila melanogaster)
Cellular responses to stress (Drosophila melanogaster)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Drosophila melanogaster)
ATP hydrolysis by HSP90 (Drosophila melanogaster)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Drosophila melanogaster)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Drosophila melanogaster)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Drosophila melanogaster)
NR3C2:NR3C2 ligands [cytosol] (Drosophila melanogaster)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Drosophila melanogaster)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Drosophila melanogaster)
NR3C2:NR3C2 ligands [cytosol] (Drosophila melanogaster)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Metabolism of steroids (Drosophila melanogaster)
Metabolism of steroid hormones (Drosophila melanogaster)
Glucocorticoid biosynthesis (Drosophila melanogaster)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)
CORT [cytosol]
Cellular responses to stimuli (Gallus gallus)
Cellular responses to stress (Gallus gallus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Gallus gallus)
ATP hydrolysis by HSP90 (Gallus gallus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Gallus gallus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Gallus gallus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Gallus gallus)
NR3C2:NR3C2 ligands [cytosol] (Gallus gallus)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Gallus gallus)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Gallus gallus)
NR3C2:NR3C2 ligands [cytosol] (Gallus gallus)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Metabolism of steroids (Gallus gallus)
Metabolism of steroid hormones (Gallus gallus)
Glucocorticoid biosynthesis (Gallus gallus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Gallus gallus)
CORT [cytosol]
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Homo sapiens)
ATP hydrolysis by HSP90 (Homo sapiens)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Homo sapiens)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Homo sapiens)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Homo sapiens)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
NR3C2:NR3C2 ligands [cytosol] (Homo sapiens)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Metabolism of steroid hormones (Homo sapiens)
Glucocorticoid biosynthesis (Homo sapiens)
Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)
CORT [cytosol]
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)
CORT [cytosol]
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Mus musculus)
ATP hydrolysis by HSP90 (Mus musculus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Mus musculus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Mus musculus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Mus musculus)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
NR3C2:NR3C2 ligands [cytosol] (Mus musculus)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Metabolism of steroids (Mus musculus)
Metabolism of steroid hormones (Mus musculus)
Glucocorticoid biosynthesis (Mus musculus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)
CORT [cytosol]
Cellular responses to stimuli (Plasmodium falciparum)
Cellular responses to stress (Plasmodium falciparum)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Plasmodium falciparum)
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Plasmodium falciparum)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Plasmodium falciparum)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Plasmodium falciparum)
NR3C2:NR3C2 ligands [cytosol] (Plasmodium falciparum)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Plasmodium falciparum)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Plasmodium falciparum)
NR3C2:NR3C2 ligands [cytosol] (Plasmodium falciparum)
NR3C2 ligands [cytosol]
CORT [cytosol]
Cellular responses to stimuli (Rattus norvegicus)
Cellular responses to stress (Rattus norvegicus)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Rattus norvegicus)
ATP hydrolysis by HSP90 (Rattus norvegicus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Rattus norvegicus)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Rattus norvegicus)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Rattus norvegicus)
NR3C2:NR3C2 ligands [cytosol] (Rattus norvegicus)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Rattus norvegicus)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Rattus norvegicus)
NR3C2:NR3C2 ligands [cytosol] (Rattus norvegicus)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Metabolism of steroids (Rattus norvegicus)
Metabolism of steroid hormones (Rattus norvegicus)
Glucocorticoid biosynthesis (Rattus norvegicus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)
CORT [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Metabolism of steroids (Schizosaccharomyces pombe)
Metabolism of steroid hormones (Schizosaccharomyces pombe)
Glucocorticoid biosynthesis (Schizosaccharomyces pombe)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)
CORT [cytosol]
Cellular responses to stimuli (Sus scrofa)
Cellular responses to stress (Sus scrofa)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Sus scrofa)
ATP hydrolysis by HSP90 (Sus scrofa)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein (Sus scrofa)
SH [cytosol]
CORT [cytosol]
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus (Sus scrofa)
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Sus scrofa)
NR3C2:NR3C2 ligands [cytosol] (Sus scrofa)
NR3C2 ligands [cytosol]
CORT [cytosol]
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Sus scrofa)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Sus scrofa)
NR3C2:NR3C2 ligands [cytosol] (Sus scrofa)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Metabolism of steroids (Sus scrofa)
Metabolism of steroid hormones (Sus scrofa)
Glucocorticoid biosynthesis (Sus scrofa)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)
CORT [cytosol]
Cellular responses to stimuli (Xenopus tropicalis)
Cellular responses to stress (Xenopus tropicalis)
HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand (Xenopus tropicalis)
NR3C2 ligands bind NR3C2 (in the HSP90 chaperone complex) (Xenopus tropicalis)
NR3C2 ligands [cytosol]
CORT [cytosol]
HSP90:ATP:FKBP4:PTGES3:NR3C2:NR3C2 ligands [cytosol] (Xenopus tropicalis)
NR3C2:NR3C2 ligands [cytosol] (Xenopus tropicalis)
NR3C2 ligands [cytosol]
CORT [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Metabolism of steroids (Xenopus tropicalis)
Metabolism of steroid hormones (Xenopus tropicalis)
Glucocorticoid biosynthesis (Xenopus tropicalis)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)
CORT [cytosol]
External Reference Information
External Reference
cortisol [ChEBI:17650]
Participates
as an output of
Cortisol translocates from the mitochondrial matrix to the cytosol (Homo sapiens)
as an input of
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Schizosaccharomyces pombe)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Drosophila melanogaster)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Gallus gallus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Xenopus tropicalis)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Danio rerio)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Sus scrofa)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Bos taurus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Canis familiaris)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Rattus norvegicus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Mus musculus)
HSD11B2,HSD11B1 dimer oxidise CORT to COR (Homo sapiens)
as a member of
SH [cytosol]
NR3C2 ligands [cytosol]
Other forms of this molecule
CORT [mitochondrial matrix]
CORT [extracellular region]
CORT [nucleoplasm]
Cross References
Guide to Pharmacology - Ligands
2868
COMPOUND
C00735
HMDB Metabolite
HMDB0000063
ZINC
ZINC000013540519
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