Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
heme [mitochondrial matrix]
Stable Identifier
R-ALL-189444
Type
Chemical Compound [SimpleEntity]
Compartment
mitochondrial matrix
Synonyms
protoheme, ferroheme b
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of porphyrins (Bos taurus)
Heme biosynthesis (Bos taurus)
ALAS condenses SUCC-CoA and Gly to form dALA (Bos taurus)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Bos taurus)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)
heme [mitochondrial matrix]
Transport of small molecules (Bos taurus)
ABC-family proteins mediated transport (Bos taurus)
Mitochondrial ABC transporters (Bos taurus)
ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)
heme [mitochondrial matrix]
Metabolism (Caenorhabditis elegans)
Metabolism of porphyrins (Caenorhabditis elegans)
Heme biosynthesis (Caenorhabditis elegans)
COX10 transforms heme to heme O (Caenorhabditis elegans)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)
heme [mitochondrial matrix]
Transport of small molecules (Caenorhabditis elegans)
ABC-family proteins mediated transport (Caenorhabditis elegans)
Mitochondrial ABC transporters (Caenorhabditis elegans)
ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)
heme [mitochondrial matrix]
Metabolism (Canis familiaris)
Metabolism of porphyrins (Canis familiaris)
Heme biosynthesis (Canis familiaris)
ALAS condenses SUCC-CoA and Gly to form dALA (Canis familiaris)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Canis familiaris)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)
heme [mitochondrial matrix]
Transport of small molecules (Canis familiaris)
ABC-family proteins mediated transport (Canis familiaris)
Mitochondrial ABC transporters (Canis familiaris)
ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)
heme [mitochondrial matrix]
Metabolism (Danio rerio)
Metabolism of porphyrins (Danio rerio)
Heme biosynthesis (Danio rerio)
ALAS condenses SUCC-CoA and Gly to form dALA (Danio rerio)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Danio rerio)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)
heme [mitochondrial matrix]
Transport of small molecules (Danio rerio)
ABC-family proteins mediated transport (Danio rerio)
Mitochondrial ABC transporters (Danio rerio)
ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)
heme [mitochondrial matrix]
Metabolism (Dictyostelium discoideum)
Metabolism of porphyrins (Dictyostelium discoideum)
Heme biosynthesis (Dictyostelium discoideum)
ALAS condenses SUCC-CoA and Gly to form dALA (Dictyostelium discoideum)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Dictyostelium discoideum)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)
heme [mitochondrial matrix]
Transport of small molecules (Dictyostelium discoideum)
ABC-family proteins mediated transport (Dictyostelium discoideum)
Mitochondrial ABC transporters (Dictyostelium discoideum)
ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)
heme [mitochondrial matrix]
Metabolism (Drosophila melanogaster)
Metabolism of porphyrins (Drosophila melanogaster)
Heme biosynthesis (Drosophila melanogaster)
ALAS condenses SUCC-CoA and Gly to form dALA (Drosophila melanogaster)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Drosophila melanogaster)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)
heme [mitochondrial matrix]
Transport of small molecules (Drosophila melanogaster)
ABC-family proteins mediated transport (Drosophila melanogaster)
Mitochondrial ABC transporters (Drosophila melanogaster)
ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)
heme [mitochondrial matrix]
Metabolism (Gallus gallus)
Heme synthesis (Gallus gallus)
protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)
heme [mitochondrial matrix]
Transport of small molecules (Gallus gallus)
ABC-family proteins mediated transport (Gallus gallus)
Mitochondrial ABC transporters (Gallus gallus)
ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)
heme [mitochondrial matrix]
Metabolism (Homo sapiens)
Metabolism of porphyrins (Homo sapiens)
Heme biosynthesis (Homo sapiens)
ALAS condenses SUCC-CoA and Gly to form dALA (Homo sapiens)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Homo sapiens)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)
heme [mitochondrial matrix]
Transport of small molecules (Homo sapiens)
ABC-family proteins mediated transport (Homo sapiens)
Mitochondrial ABC transporters (Homo sapiens)
ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)
heme [mitochondrial matrix]
Metabolism (Mus musculus)
Metabolism of porphyrins (Mus musculus)
Heme biosynthesis (Mus musculus)
ALAS condenses SUCC-CoA and Gly to form dALA (Mus musculus)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Mus musculus)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)
heme [mitochondrial matrix]
Transport of small molecules (Mus musculus)
ABC-family proteins mediated transport (Mus musculus)
Mitochondrial ABC transporters (Mus musculus)
ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)
heme [mitochondrial matrix]
Metabolism (Plasmodium falciparum)
Metabolism of porphyrins (Plasmodium falciparum)
Heme biosynthesis (Plasmodium falciparum)
ALAS condenses SUCC-CoA and Gly to form dALA (Plasmodium falciparum)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Plasmodium falciparum)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)
heme [mitochondrial matrix]
Metabolism (Rattus norvegicus)
Metabolism of porphyrins (Rattus norvegicus)
Heme biosynthesis (Rattus norvegicus)
ALAS condenses SUCC-CoA and Gly to form dALA (Rattus norvegicus)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Rattus norvegicus)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)
heme [mitochondrial matrix]
Transport of small molecules (Rattus norvegicus)
ABC-family proteins mediated transport (Rattus norvegicus)
Mitochondrial ABC transporters (Rattus norvegicus)
ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)
heme [mitochondrial matrix]
Metabolism (Saccharomyces cerevisiae)
Metabolism of porphyrins (Saccharomyces cerevisiae)
Heme biosynthesis (Saccharomyces cerevisiae)
ALAS condenses SUCC-CoA and Gly to form dALA (Saccharomyces cerevisiae)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Saccharomyces cerevisiae)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)
heme [mitochondrial matrix]
Transport of small molecules (Saccharomyces cerevisiae)
ABC-family proteins mediated transport (Saccharomyces cerevisiae)
Mitochondrial ABC transporters (Saccharomyces cerevisiae)
ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)
heme [mitochondrial matrix]
Metabolism (Schizosaccharomyces pombe)
Metabolism of porphyrins (Schizosaccharomyces pombe)
Heme biosynthesis (Schizosaccharomyces pombe)
ALAS condenses SUCC-CoA and Gly to form dALA (Schizosaccharomyces pombe)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Schizosaccharomyces pombe)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)
heme [mitochondrial matrix]
Transport of small molecules (Schizosaccharomyces pombe)
ABC-family proteins mediated transport (Schizosaccharomyces pombe)
Mitochondrial ABC transporters (Schizosaccharomyces pombe)
ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)
heme [mitochondrial matrix]
Metabolism (Sus scrofa)
Metabolism of porphyrins (Sus scrofa)
Heme biosynthesis (Sus scrofa)
ALAS condenses SUCC-CoA and Gly to form dALA (Sus scrofa)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Sus scrofa)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)
heme [mitochondrial matrix]
Transport of small molecules (Sus scrofa)
ABC-family proteins mediated transport (Sus scrofa)
Mitochondrial ABC transporters (Sus scrofa)
ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)
heme [mitochondrial matrix]
Metabolism (Xenopus tropicalis)
Metabolism of porphyrins (Xenopus tropicalis)
Heme biosynthesis (Xenopus tropicalis)
ALAS condenses SUCC-CoA and Gly to form dALA (Xenopus tropicalis)
heme [mitochondrial matrix]
COX10 transforms heme to heme O (Xenopus tropicalis)
heme [mitochondrial matrix]
FECH binds Fe2+ to PRIN9 to form heme (Xenopus tropicalis)
heme [mitochondrial matrix]
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)
heme [mitochondrial matrix]
Transport of small molecules (Xenopus tropicalis)
ABC-family proteins mediated transport (Xenopus tropicalis)
Mitochondrial ABC transporters (Xenopus tropicalis)
ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)
heme [mitochondrial matrix]
External Reference Information
External Reference
ferroheme b [ChEBI:17627]
Participates
as an input of
ABC7, mABC1 and mABC2 mediate heme transport (Saccharomyces cerevisiae)
ABC7, mABC1 and mABC2 mediate heme transport (Schizosaccharomyces pombe)
ABC7, mABC1 and mABC2 mediate heme transport (Dictyostelium discoideum)
ABC7, mABC1 and mABC2 mediate heme transport (Caenorhabditis elegans)
ABC7, mABC1 and mABC2 mediate heme transport (Drosophila melanogaster)
ABC7, mABC1 and mABC2 mediate heme transport (Gallus gallus)
ABC7, mABC1 and mABC2 mediate heme transport (Xenopus tropicalis)
ABC7, mABC1 and mABC2 mediate heme transport (Danio rerio)
ABC7, mABC1 and mABC2 mediate heme transport (Sus scrofa)
ABC7, mABC1 and mABC2 mediate heme transport (Bos taurus)
ABC7, mABC1 and mABC2 mediate heme transport (Canis familiaris)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Homo sapiens)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Mus musculus)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Rattus norvegicus)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Canis familiaris)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Bos taurus)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Sus scrofa)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Danio rerio)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Xenopus tropicalis)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Gallus gallus)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Drosophila melanogaster)
FLVCR1-2 transports heme from mitochondrial matrix to cytosol (Caenorhabditis elegans)
COX10 transforms heme to heme O (Homo sapiens)
COX10 transforms heme to heme O (Mus musculus)
COX10 transforms heme to heme O (Rattus norvegicus)
COX10 transforms heme to heme O (Canis familiaris)
COX10 transforms heme to heme O (Bos taurus)
COX10 transforms heme to heme O (Sus scrofa)
COX10 transforms heme to heme O (Danio rerio)
COX10 transforms heme to heme O (Xenopus tropicalis)
COX10 transforms heme to heme O (Gallus gallus)
COX10 transforms heme to heme O (Drosophila melanogaster)
COX10 transforms heme to heme O (Caenorhabditis elegans)
COX10 transforms heme to heme O (Dictyostelium discoideum)
COX10 transforms heme to heme O (Schizosaccharomyces pombe)
COX10 transforms heme to heme O (Saccharomyces cerevisiae)
COX10 transforms heme to heme O (Plasmodium falciparum)
ABC7, mABC1 and mABC2 mediate heme transport (Homo sapiens)
ABC7, mABC1 and mABC2 mediate heme transport (Mus musculus)
ABC7, mABC1 and mABC2 mediate heme transport (Rattus norvegicus)
as an output of
protoporphyrin IX + Fe++ => heme + 2 H+ (Gallus gallus)
FECH binds Fe2+ to PRIN9 to form heme (Homo sapiens)
FECH binds Fe2+ to PRIN9 to form heme (Mus musculus)
FECH binds Fe2+ to PRIN9 to form heme (Rattus norvegicus)
FECH binds Fe2+ to PRIN9 to form heme (Canis familiaris)
FECH binds Fe2+ to PRIN9 to form heme (Bos taurus)
FECH binds Fe2+ to PRIN9 to form heme (Sus scrofa)
FECH binds Fe2+ to PRIN9 to form heme (Danio rerio)
FECH binds Fe2+ to PRIN9 to form heme (Xenopus tropicalis)
FECH binds Fe2+ to PRIN9 to form heme (Gallus gallus)
FECH binds Fe2+ to PRIN9 to form heme (Drosophila melanogaster)
FECH binds Fe2+ to PRIN9 to form heme (Caenorhabditis elegans)
FECH binds Fe2+ to PRIN9 to form heme (Dictyostelium discoideum)
FECH binds Fe2+ to PRIN9 to form heme (Schizosaccharomyces pombe)
FECH binds Fe2+ to PRIN9 to form heme (Saccharomyces cerevisiae)
FECH binds Fe2+ to PRIN9 to form heme (Plasmodium falciparum)
This entity regulates
Negatively
ALAS condenses SUCC-CoA and Gly to form dALA
(Plasmodium falciparum)
ALAS condenses SUCC-CoA and Gly to form dALA
(Saccharomyces cerevisiae)
ALAS condenses SUCC-CoA and Gly to form dALA
(Schizosaccharomyces pombe)
ALAS condenses SUCC-CoA and Gly to form dALA
(Dictyostelium discoideum)
ALAS condenses SUCC-CoA and Gly to form dALA
(Drosophila melanogaster)
ALAS condenses SUCC-CoA and Gly to form dALA
(Gallus gallus)
ALAS condenses SUCC-CoA and Gly to form dALA
(Xenopus tropicalis)
ALAS condenses SUCC-CoA and Gly to form dALA
(Danio rerio)
ALAS condenses SUCC-CoA and Gly to form dALA
(Sus scrofa)
ALAS condenses SUCC-CoA and Gly to form dALA
(Bos taurus)
ALAS condenses SUCC-CoA and Gly to form dALA
(Canis familiaris)
ALAS condenses SUCC-CoA and Gly to form dALA
(Rattus norvegicus)
ALAS condenses SUCC-CoA and Gly to form dALA
(Mus musculus)
ALAS condenses SUCC-CoA and Gly to form dALA
(Homo sapiens)
Other forms of this molecule
heme [mitochondrial outer membrane]
ferroheme b [endocytic vesicle lumen]
heme [nucleoplasm]
heme [nuclear envelope]
heme [peroxisomal matrix]
heme [plasma membrane]
heme [extracellular region]
heme [cytosol]
Cross References
COMPOUND
C00032
PubChem Substance
8145503
HMDB Metabolite
HMDB0003178
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text