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LacCer [lysosomal lumen]
Stable Identifier
R-ALL-1605601
Type
Chemical Compound [SimpleEntity]
Compartment
lysosomal lumen
Synonyms
Lactosylceramide, beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingosine, beta-D-Galactosyl-1,4-beta-D-glucosylceramide
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of lipids (Bos taurus)
Sphingolipid metabolism (Bos taurus)
Glycosphingolipid metabolism (Bos taurus)
Glycosphingolipid catabolism (Bos taurus)
ARSA removes sulfate from SM3 (Bos taurus)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Bos taurus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Bos taurus)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Bos taurus)
Sap B/C:LacCer [lysosomal lumen] (Bos taurus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Bos taurus)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Bos taurus)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Bos taurus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Bos taurus)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Bos taurus)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Bos taurus)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Bos taurus)
GM2A:LacCer [lysosomal lumen] (Bos taurus)
LacCer [lysosomal lumen]
Metabolism (Caenorhabditis elegans)
Metabolism of lipids (Caenorhabditis elegans)
Sphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid metabolism (Caenorhabditis elegans)
Glycosphingolipid catabolism (Caenorhabditis elegans)
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Caenorhabditis elegans)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Caenorhabditis elegans)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Caenorhabditis elegans)
Sap B/C:LacCer [lysosomal lumen] (Caenorhabditis elegans)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Caenorhabditis elegans)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Caenorhabditis elegans)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Caenorhabditis elegans)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Caenorhabditis elegans)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Caenorhabditis elegans)
GM2A:LacCer [lysosomal lumen] (Caenorhabditis elegans)
LacCer [lysosomal lumen]
Metabolism (Canis familiaris)
Metabolism of lipids (Canis familiaris)
Sphingolipid metabolism (Canis familiaris)
Glycosphingolipid metabolism (Canis familiaris)
Glycosphingolipid catabolism (Canis familiaris)
ARSA removes sulfate from SM3 (Canis familiaris)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Canis familiaris)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Canis familiaris)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Canis familiaris)
Sap B/C:LacCer [lysosomal lumen] (Canis familiaris)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Canis familiaris)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Canis familiaris)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Canis familiaris)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Canis familiaris)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Canis familiaris)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Canis familiaris)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Canis familiaris)
GM2A:LacCer [lysosomal lumen] (Canis familiaris)
LacCer [lysosomal lumen]
Metabolism (Dictyostelium discoideum)
Metabolism of lipids (Dictyostelium discoideum)
Sphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid metabolism (Dictyostelium discoideum)
Glycosphingolipid catabolism (Dictyostelium discoideum)
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Dictyostelium discoideum)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Dictyostelium discoideum)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Dictyostelium discoideum)
Sap B/C:LacCer [lysosomal lumen] (Dictyostelium discoideum)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Dictyostelium discoideum)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Dictyostelium discoideum)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Dictyostelium discoideum)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Dictyostelium discoideum)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
Metabolism (Drosophila melanogaster)
Metabolism of lipids (Drosophila melanogaster)
Sphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid metabolism (Drosophila melanogaster)
Glycosphingolipid catabolism (Drosophila melanogaster)
GLB1 hydrolyzes SapB/C:LacCer (Drosophila melanogaster)
Sap B/C:LacCer [lysosomal lumen] (Drosophila melanogaster)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Drosophila melanogaster)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Drosophila melanogaster)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Drosophila melanogaster)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Drosophila melanogaster)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
Metabolism (Gallus gallus)
Metabolism of lipids (Gallus gallus)
Sphingolipid metabolism (Gallus gallus)
Glycosphingolipid metabolism (Gallus gallus)
Glycosphingolipid catabolism (Gallus gallus)
ARSA removes sulfate from SM3 (Gallus gallus)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Gallus gallus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Gallus gallus)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Gallus gallus)
Sap B/C:LacCer [lysosomal lumen] (Gallus gallus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Gallus gallus)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Gallus gallus)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Gallus gallus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Gallus gallus)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Gallus gallus)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Gallus gallus)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
ARSA removes sulfate from SM3 (Homo sapiens)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Homo sapiens)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Homo sapiens)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Homo sapiens)
Sap B/C:LacCer [lysosomal lumen] (Homo sapiens)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Homo sapiens)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Homo sapiens)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Homo sapiens)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Homo sapiens)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Homo sapiens)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Homo sapiens)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Homo sapiens)
GM2A:LacCer [lysosomal lumen] (Homo sapiens)
LacCer [lysosomal lumen]
Metabolism (Mus musculus)
Metabolism of lipids (Mus musculus)
Sphingolipid metabolism (Mus musculus)
Glycosphingolipid metabolism (Mus musculus)
Glycosphingolipid catabolism (Mus musculus)
ARSA removes sulfate from SM3 (Mus musculus)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Mus musculus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Mus musculus)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Mus musculus)
Sap B/C:LacCer [lysosomal lumen] (Mus musculus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Mus musculus)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Mus musculus)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Mus musculus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Mus musculus)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Mus musculus)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Mus musculus)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Mus musculus)
GM2A:LacCer [lysosomal lumen] (Mus musculus)
LacCer [lysosomal lumen]
Metabolism (Rattus norvegicus)
Metabolism of lipids (Rattus norvegicus)
Sphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid metabolism (Rattus norvegicus)
Glycosphingolipid catabolism (Rattus norvegicus)
ARSA removes sulfate from SM3 (Rattus norvegicus)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Rattus norvegicus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Rattus norvegicus)
Sap B/C:LacCer [lysosomal lumen] (Rattus norvegicus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Rattus norvegicus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Rattus norvegicus)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Rattus norvegicus)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Rattus norvegicus)
GM2A:LacCer [lysosomal lumen] (Rattus norvegicus)
LacCer [lysosomal lumen]
Metabolism (Schizosaccharomyces pombe)
Metabolism of lipids (Schizosaccharomyces pombe)
Sphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid metabolism (Schizosaccharomyces pombe)
Glycosphingolipid catabolism (Schizosaccharomyces pombe)
ARSA removes sulfate from SM3 (Schizosaccharomyces pombe)
LacCer [lysosomal lumen]
Metabolism (Sus scrofa)
Metabolism of lipids (Sus scrofa)
Sphingolipid metabolism (Sus scrofa)
Glycosphingolipid metabolism (Sus scrofa)
Glycosphingolipid catabolism (Sus scrofa)
ARSA removes sulfate from SM3 (Sus scrofa)
LacCer [lysosomal lumen]
GLA hydrolyzes PSAP(195-273):Gb3Cer:PE (Sus scrofa)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Sus scrofa)
LacCer [lysosomal lumen]
GLB1 hydrolyzes SapB/C:LacCer (Sus scrofa)
Sap B/C:LacCer [lysosomal lumen] (Sus scrofa)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Sus scrofa)
LacCer [lysosomal lumen]
PSAP(311-391):LacCer:PE [lysosomal lumen] (Sus scrofa)
LacCer [lysosomal lumen]
NEU1,4 hydrolyze PSAP(195-273):GM3:PE (Sus scrofa)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Sus scrofa)
LacCer [lysosomal lumen]
PSAP(195-273) dimer:PE binds and mobilizes ligands (Sus scrofa)
PSAP(195-273):Ligands:PE [lysosomal lumen] (Sus scrofa)
PSAP(195-273) ligands [lysosomal lumen]
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Sus scrofa)
GM2A:LacCer [lysosomal lumen] (Sus scrofa)
LacCer [lysosomal lumen]
Metabolism (Xenopus tropicalis)
Metabolism of lipids (Xenopus tropicalis)
Sphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid metabolism (Xenopus tropicalis)
Glycosphingolipid catabolism (Xenopus tropicalis)
ARSA removes sulfate from SM3 (Xenopus tropicalis)
LacCer [lysosomal lumen]
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Xenopus tropicalis)
GM2A:LacCer [lysosomal lumen] (Xenopus tropicalis)
LacCer [lysosomal lumen]
External Reference Information
External Reference
beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-N-acylsphingoid [ChEBI:195546]
Participates
as a component of
GM2A:LacCer [lysosomal lumen] (Mus musculus)
GM2A:LacCer [lysosomal lumen] (Xenopus tropicalis)
GM2A:LacCer [lysosomal lumen] (Caenorhabditis elegans)
GM2A:LacCer [lysosomal lumen] (Bos taurus)
GM2A:LacCer [lysosomal lumen] (Canis familiaris)
GM2A:LacCer [lysosomal lumen] (Sus scrofa)
GM2A:LacCer [lysosomal lumen] (Rattus norvegicus)
GM2A:LacCer [lysosomal lumen] (Homo sapiens)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Sus scrofa)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Canis familiaris)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Caenorhabditis elegans)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Bos taurus)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Mus musculus)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Dictyostelium discoideum)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Gallus gallus)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Drosophila melanogaster)
PSAP(311-391):LacCer:PE [lysosomal lumen] (Homo sapiens)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Gallus gallus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Dictyostelium discoideum)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Bos taurus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Canis familiaris)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Caenorhabditis elegans)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Rattus norvegicus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Drosophila melanogaster)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Mus musculus)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Sus scrofa)
PSAP(195-273):LacCer:PE [lysosomal lumen] (Homo sapiens)
as an output of
ARSA removes sulfate from SM3 (Schizosaccharomyces pombe)
ARSA removes sulfate from SM3 (Gallus gallus)
ARSA removes sulfate from SM3 (Xenopus tropicalis)
ARSA removes sulfate from SM3 (Sus scrofa)
ARSA removes sulfate from SM3 (Bos taurus)
ARSA removes sulfate from SM3 (Canis familiaris)
ARSA removes sulfate from SM3 (Rattus norvegicus)
ARSA removes sulfate from SM3 (Mus musculus)
ARSA removes sulfate from SM3 (Homo sapiens)
as a member of
PSAP(195-273) ligands [lysosomal lumen]
Other forms of this molecule
LacCer [plasma membrane]
LacCer [cytosol]
LacCer [multivesicular body, internal vesicle membrane]
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