Reactome | WZ4002 [cytosol]

WZ4002 [cytosol]

Stable Identifier

R-ALL-1227674

Type

ChemicalDrug

Compartment

cytosol

Synonyms

Irreversible tyrosine kinase inhibitor WZ4002 EGFR specific

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
  - Signaling by EGFR in Cancer (Homo sapiens)
    - Signaling by Ligand-Responsive EGFR Variants in Cancer (Homo sapiens)
      - Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants (Homo sapiens)
        
        Covalent tyrosine kinase inhibitors bind and inactivate EGFR kinase domain mutant dimers resistant to non-covalent tyrosine kinase inhibitors (Homo sapiens)
        
        Covalent EGFR tyrosine kinase inhibitors [cytosol]
        
        Irreversible EGFR-specific TKIs [cytosol]
        
        WZ4002 [cytosol]
        
        Resistant ligand-responsive EGFR mutants:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
        
        Covalent EGFR tyrosine kinase inhibitors [cytosol]
        
        Irreversible EGFR-specific TKIs [cytosol]
        
        WZ4002 [cytosol]
    - Signaling by Overexpressed Wild-Type EGFR in Cancer (Homo sapiens)
      - Inhibition of Signaling by Overexpressed EGFR (Homo sapiens)
        
        Covalent tyrosine kinase inhibitors bind and inhibit wild-type EGF:EGFR dimers (Homo sapiens)
        
        Covalent EGFR tyrosine kinase inhibitors [cytosol]
        
        Irreversible EGFR-specific TKIs [cytosol]
        
        WZ4002 [cytosol]
        
        EGF-like ligands:EGFR Dimer:Covalent EGFR TKIs [plasma membrane] (Homo sapiens)
        
        Covalent EGFR tyrosine kinase inhibitors [cytosol]
        
        Irreversible EGFR-specific TKIs [cytosol]
        
        WZ4002 [cytosol]

Participant Of

hasMember

Irreversible EGFR-specific TKIs [cytosol]

Disease

Name	Identifier	Synonyms
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Cross References

ChEBI

61400

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