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Ca2+ [endoplasmic reticulum lumen]
Stable Identifier
R-ALL-111875
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum lumen
Synonyms
Calcium, calcium(2+)
Icon
Locations in the PathwayBrowser for interactor UniProt:P13497%20BMP1
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Muscle contraction (Bos taurus)
Cardiac conduction (Bos taurus)
Ion homeostasis (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Bos taurus)
Sensory perception of taste (Bos taurus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Bos taurus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Bos taurus)
Ion channel transport (Bos taurus)
Ion transport by P-type ATPases (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Caenorhabditis elegans)
Cardiac conduction (Caenorhabditis elegans)
Ion homeostasis (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Caenorhabditis elegans)
Sensory perception of taste (Caenorhabditis elegans)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Caenorhabditis elegans)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Caenorhabditis elegans)
Ion channel transport (Caenorhabditis elegans)
Ion transport by P-type ATPases (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Canis familiaris)
Cardiac conduction (Canis familiaris)
Ion homeostasis (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Canis familiaris)
Sensory perception of taste (Canis familiaris)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Canis familiaris)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Canis familiaris)
Ion channel transport (Canis familiaris)
Ion transport by P-type ATPases (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Danio rerio)
Cardiac conduction (Danio rerio)
Ion homeostasis (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Danio rerio)
Ion channel transport (Danio rerio)
Ion transport by P-type ATPases (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Dictyostelium discoideum)
Sensory perception of taste (Dictyostelium discoideum)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Dictyostelium discoideum)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Drosophila melanogaster)
Cardiac conduction (Drosophila melanogaster)
Ion homeostasis (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Drosophila melanogaster)
Sensory perception of taste (Drosophila melanogaster)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Drosophila melanogaster)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Drosophila melanogaster)
Ion channel transport (Drosophila melanogaster)
Ion transport by P-type ATPases (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Gallus gallus)
Cardiac conduction (Gallus gallus)
Ion homeostasis (Gallus gallus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Gallus gallus)
Ion channel transport (Gallus gallus)
Ion transport by P-type ATPases (Gallus gallus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
Ca2+ [endoplasmic reticulum lumen]
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
CLEC7A (Dectin-1) induces NFAT activation (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Role of phospholipids in phagocytosis (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Metabolism (Homo sapiens)
Integration of energy metabolism (Homo sapiens)
Regulation of insulin secretion (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Homo sapiens)
Cardiac conduction (Homo sapiens)
Ion homeostasis (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Homo sapiens)
Sensory perception of taste (Homo sapiens)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Homo sapiens)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Signal Transduction (Homo sapiens)
Intracellular signaling by second messengers (Homo sapiens)
DAG and IP3 signaling (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Opioid Signalling (Homo sapiens)
G-protein mediated events (Homo sapiens)
PLC beta mediated events (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
VEGFR2 mediated cell proliferation (Homo sapiens)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
Ca2+ pathway (Homo sapiens)
Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Homo sapiens)
Ion channel transport (Homo sapiens)
Ion transport by P-type ATPases (Homo sapiens)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Mus musculus)
Cardiac conduction (Mus musculus)
Ion homeostasis (Mus musculus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Mus musculus)
Sensory perception of taste (Mus musculus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Mus musculus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Mus musculus)
Ion channel transport (Mus musculus)
Ion transport by P-type ATPases (Mus musculus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Plasmodium falciparum)
Cardiac conduction (Plasmodium falciparum)
Ion homeostasis (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Plasmodium falciparum)
Ion channel transport (Plasmodium falciparum)
Ion transport by P-type ATPases (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Rattus norvegicus)
Cardiac conduction (Rattus norvegicus)
Ion homeostasis (Rattus norvegicus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Rattus norvegicus)
Sensory perception of taste (Rattus norvegicus)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Rattus norvegicus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Rattus norvegicus)
Ion channel transport (Rattus norvegicus)
Ion transport by P-type ATPases (Rattus norvegicus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Sus scrofa)
Cardiac conduction (Sus scrofa)
Ion homeostasis (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Sus scrofa)
Sensory perception of taste (Sus scrofa)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Sus scrofa)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Sus scrofa)
Ion channel transport (Sus scrofa)
Ion transport by P-type ATPases (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
Ca2+ [endoplasmic reticulum lumen]
Muscle contraction (Xenopus tropicalis)
Cardiac conduction (Xenopus tropicalis)
Ion homeostasis (Xenopus tropicalis)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
Ca2+ [endoplasmic reticulum lumen]
Sensory Perception (Xenopus tropicalis)
Sensory perception of taste (Xenopus tropicalis)
Sensory perception of sweet, bitter, and umami (glutamate) taste (Xenopus tropicalis)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)
Ca2+ [endoplasmic reticulum lumen]
Transport of small molecules (Xenopus tropicalis)
Ion channel transport (Xenopus tropicalis)
Ion transport by P-type ATPases (Xenopus tropicalis)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
Ca2+ [endoplasmic reticulum lumen]
External Reference Information
External Reference
calcium(2+) [ChEBI:29108]
Participates
as an input of
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Dictyostelium discoideum)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Caenorhabditis elegans)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Drosophila melanogaster)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Xenopus tropicalis)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Sus scrofa)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Bos taurus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Canis familiaris)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Rattus norvegicus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Mus musculus)
ITPR3 transports Ca2+ from the endoplasmic reticulum to the cytosol (Homo sapiens)
Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT (Homo sapiens)
Calcium release from intracellular stores by IP3 receptor activation (Rattus norvegicus)
IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol (Homo sapiens)
as an output of
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Plasmodium falciparum)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Caenorhabditis elegans)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Drosophila melanogaster)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Gallus gallus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Xenopus tropicalis)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Danio rerio)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Sus scrofa)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Bos taurus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Canis familiaris)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Rattus norvegicus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Mus musculus)
ATP2A1-3 transport Ca2+ from cytosol to ER lumen (Homo sapiens)
as a component of
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Sus scrofa)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Rattus norvegicus)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Gallus gallus)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Schizosaccharomyces pombe)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Canis familiaris)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Bos taurus)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Xenopus tropicalis)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Homo sapiens)
active ARSA:Ca2+ [endoplasmic reticulum lumen] (Mus musculus)
convertase (Calcium dependant) [endoplasmic reticulum lumen] (Mus musculus)
STIM1:Calcium [endoplasmic reticulum membrane] (Sus scrofa)
STIM1:Calcium [endoplasmic reticulum membrane] (Rattus norvegicus)
STIM1:Calcium [endoplasmic reticulum membrane] (Bos taurus)
STIM1:Calcium [endoplasmic reticulum membrane] (Canis familiaris)
STIM1:Calcium [endoplasmic reticulum membrane] (Caenorhabditis elegans)
STIM1:Calcium [endoplasmic reticulum membrane] (Xenopus tropicalis)
STIM1:Calcium [endoplasmic reticulum membrane] (Drosophila melanogaster)
STIM1:Calcium [endoplasmic reticulum membrane] (Gallus gallus)
STIM1:Calcium [endoplasmic reticulum membrane] (Mus musculus)
STIM1:Calcium [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
Ca2+ [platelet dense granule lumen]
Ca2+ [endosome membrane]
Ca2+ [sarcoplasmic reticulum lumen]
Ca2+ [mitochondrial intermembrane space]
Ca2+ [endocytic vesicle lumen]
Ca2+ [lysosomal lumen]
Ca2+ [endoplasmic reticulum-Golgi intermediate compartment]
Ca2+ [Golgi lumen]
Ca2+ [platelet dense tubular network lumen]
Ca2+ [platelet dense tubular network membrane]
Ca2+ [plasma membrane]
Ca2+ [secretory granule lumen]
Ca2+ [nuclear envelope]
Ca2+ [nucleoplasm]
Ca2+ [mitochondrial matrix]
Ca2+ [mitochondrial inner membrane]
Ca2+ [endoplasmic reticulum membrane]
Ca2+ [cytosol]
Ca2+ [extracellular region]
Cross References
COMPOUND
C00076
PubChem Substance
8145461
HMDB Metabolite
HMDB0000464
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![Ca2+ [endoplasmic reticulum lumen] icon](/icon/R-ICO-012501.svg){kind=icon}
