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4aOH-BH4 [cytosol]
Stable Identifier
R-ALL-71112
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
4a-hydroxytetrahydrobiopterin
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Plasmodium falciparum
Rattus norvegicus
Saccharomyces cerevisiae
Schizosaccharomyces pombe
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Metabolism of amine-derived hormones (Bos taurus)
Catecholamine biosynthesis (Bos taurus)
Tyrosine is hydroxylated to dopa (Bos taurus)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Bos taurus)
Tryptophan is hydroxylated (Bos taurus)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Bos taurus)
Phenylalanine metabolism (Bos taurus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
4aOH-BH4 [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Metabolism of amine-derived hormones (Caenorhabditis elegans)
Catecholamine biosynthesis (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Caenorhabditis elegans)
Tryptophan is hydroxylated (Caenorhabditis elegans)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Phenylalanine metabolism (Caenorhabditis elegans)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
4aOH-BH4 [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Metabolism of amine-derived hormones (Canis familiaris)
Catecholamine biosynthesis (Canis familiaris)
Tyrosine is hydroxylated to dopa (Canis familiaris)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Canis familiaris)
Tryptophan is hydroxylated (Canis familiaris)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Canis familiaris)
Phenylalanine metabolism (Canis familiaris)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
4aOH-BH4 [cytosol]
Metabolism (Danio rerio)
Metabolism of amino acids and derivatives (Danio rerio)
Metabolism of amine-derived hormones (Danio rerio)
Catecholamine biosynthesis (Danio rerio)
Tyrosine is hydroxylated to dopa (Danio rerio)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Danio rerio)
Tryptophan is hydroxylated (Danio rerio)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Danio rerio)
Phenylalanine metabolism (Danio rerio)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
4aOH-BH4 [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Metabolism of amine-derived hormones (Dictyostelium discoideum)
Catecholamine biosynthesis (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Dictyostelium discoideum)
Tryptophan is hydroxylated (Dictyostelium discoideum)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Phenylalanine metabolism (Dictyostelium discoideum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
4aOH-BH4 [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Metabolism of amine-derived hormones (Drosophila melanogaster)
Catecholamine biosynthesis (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Drosophila melanogaster)
Tryptophan is hydroxylated (Drosophila melanogaster)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Phenylalanine metabolism (Drosophila melanogaster)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
4aOH-BH4 [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Metabolism of amine-derived hormones (Gallus gallus)
Catecholamine biosynthesis (Gallus gallus)
Tyrosine is hydroxylated to dopa (Gallus gallus)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Gallus gallus)
Tryptophan is hydroxylated (Gallus gallus)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Gallus gallus)
Phenylalanine metabolism (Gallus gallus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
4aOH-BH4 [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Metabolism of amine-derived hormones (Homo sapiens)
Catecholamine biosynthesis (Homo sapiens)
Tyrosine is hydroxylated to dopa (Homo sapiens)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Homo sapiens)
Tryptophan is hydroxylated (Homo sapiens)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Homo sapiens)
Phenylalanine metabolism (Homo sapiens)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
4aOH-BH4 [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Metabolism of amine-derived hormones (Mus musculus)
Catecholamine biosynthesis (Mus musculus)
Tyrosine is hydroxylated to dopa (Mus musculus)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Mus musculus)
Tryptophan is hydroxylated (Mus musculus)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Mus musculus)
Phenylalanine metabolism (Mus musculus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
4aOH-BH4 [cytosol]
Metabolism (Plasmodium falciparum)
Metabolism of amino acids and derivatives (Plasmodium falciparum)
Phenylalanine and tyrosine metabolism (Plasmodium falciparum)
Phenylalanine metabolism (Plasmodium falciparum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)
4aOH-BH4 [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Metabolism of amine-derived hormones (Rattus norvegicus)
Catecholamine biosynthesis (Rattus norvegicus)
Tyrosine is hydroxylated to dopa (Rattus norvegicus)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Rattus norvegicus)
Tryptophan is hydroxylated (Rattus norvegicus)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Phenylalanine metabolism (Rattus norvegicus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
4aOH-BH4 [cytosol]
Metabolism (Saccharomyces cerevisiae)
Metabolism of amino acids and derivatives (Saccharomyces cerevisiae)
Phenylalanine and tyrosine metabolism (Saccharomyces cerevisiae)
Phenylalanine metabolism (Saccharomyces cerevisiae)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)
4aOH-BH4 [cytosol]
Metabolism (Schizosaccharomyces pombe)
Metabolism of amino acids and derivatives (Schizosaccharomyces pombe)
Phenylalanine and tyrosine metabolism (Schizosaccharomyces pombe)
Phenylalanine metabolism (Schizosaccharomyces pombe)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)
4aOH-BH4 [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Metabolism of amine-derived hormones (Sus scrofa)
Catecholamine biosynthesis (Sus scrofa)
Tyrosine is hydroxylated to dopa (Sus scrofa)
4aOH-BH4 [cytosol]
Serotonin and melatonin biosynthesis (Sus scrofa)
Tryptophan is hydroxylated (Sus scrofa)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Sus scrofa)
Phenylalanine metabolism (Sus scrofa)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
4aOH-BH4 [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Metabolism of amine-derived hormones (Xenopus tropicalis)
Catecholamine biosynthesis (Xenopus tropicalis)
Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
4aOH-BH4 [cytosol]
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Phenylalanine metabolism (Xenopus tropicalis)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)
4aOH-BH4 [cytosol]
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
4aOH-BH4 [cytosol]
Literature References
PubMed ID
Title
Journal
Year
The Metabolic and Molecular Bases of Inherited Disease, 8th ed
Beaudet, AL
,
Scriver, CR
,
Sly, WS
,
Valle, D
2001
External Reference Information
External Reference
4a-hydroxytetrahydrobiopterin [ChEBI:15374]
Participates
as an input of
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Homo sapiens)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Mus musculus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Rattus norvegicus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Canis familiaris)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Bos taurus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Sus scrofa)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Danio rerio)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Xenopus tropicalis)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Gallus gallus)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Drosophila melanogaster)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Caenorhabditis elegans)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Dictyostelium discoideum)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Schizosaccharomyces pombe)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Saccharomyces cerevisiae)
4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O (Plasmodium falciparum)
as an output of
Tyrosine is hydroxylated to dopa (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Caenorhabditis elegans)
Tyrosine is hydroxylated to dopa (Drosophila melanogaster)
Tyrosine is hydroxylated to dopa (Gallus gallus)
Tryptophan is hydroxylated (Homo sapiens)
Tryptophan is hydroxylated (Mus musculus)
Tryptophan is hydroxylated (Rattus norvegicus)
Tryptophan is hydroxylated (Canis familiaris)
Tryptophan is hydroxylated (Bos taurus)
Tryptophan is hydroxylated (Sus scrofa)
Tryptophan is hydroxylated (Danio rerio)
Tryptophan is hydroxylated (Gallus gallus)
Tryptophan is hydroxylated (Drosophila melanogaster)
Tryptophan is hydroxylated (Caenorhabditis elegans)
Tryptophan is hydroxylated (Dictyostelium discoideum)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Homo sapiens)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Mus musculus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Rattus norvegicus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Canis familiaris)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Bos taurus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Sus scrofa)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Danio rerio)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Xenopus tropicalis)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Gallus gallus)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Drosophila melanogaster)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Caenorhabditis elegans)
PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (Dictyostelium discoideum)
Tyrosine is hydroxylated to dopa (Bos taurus)
Tyrosine is hydroxylated to dopa (Homo sapiens)
Tyrosine is hydroxylated to dopa (Mus musculus)
Tyrosine is hydroxylated to dopa (Rattus norvegicus)
Tyrosine is hydroxylated to dopa (Canis familiaris)
Tyrosine is hydroxylated to dopa (Sus scrofa)
Tyrosine is hydroxylated to dopa (Danio rerio)
Tyrosine is hydroxylated to dopa (Xenopus tropicalis)
Cross References
PubChem Substance
8145822
ZINC
ZINC000095661187
,
ZINC000040164376
,
ZINC000040164375
,
ZINC000030729381
,
ZINC000013526630
,
ZINC000013526626
,
ZINC000012495761
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