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TMA [endoplasmic reticulum lumen]
Stable Identifier
R-ALL-30373
Type
Chemical Compound [SimpleEntity]
Compartment
endoplasmic reticulum lumen
Synonyms
(CH3)3N, trimethylamine, N,N-Dimethylmethanamine
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Metabolism (Bos taurus)
Biological oxidations (Bos taurus)
Phase I - Functionalization of compounds (Bos taurus)
FMO oxidises nucleophiles (Bos taurus)
FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)
TMA [endoplasmic reticulum lumen]
Metabolism (Caenorhabditis elegans)
Biological oxidations (Caenorhabditis elegans)
Phase I - Functionalization of compounds (Caenorhabditis elegans)
FMO oxidises nucleophiles (Caenorhabditis elegans)
FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)
TMA [endoplasmic reticulum lumen]
Metabolism (Canis familiaris)
Biological oxidations (Canis familiaris)
Phase I - Functionalization of compounds (Canis familiaris)
FMO oxidises nucleophiles (Canis familiaris)
FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)
TMA [endoplasmic reticulum lumen]
Metabolism (Danio rerio)
Biological oxidations (Danio rerio)
Phase I - Functionalization of compounds (Danio rerio)
FMO oxidises nucleophiles (Danio rerio)
FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)
TMA [endoplasmic reticulum lumen]
Metabolism (Dictyostelium discoideum)
Biological oxidations (Dictyostelium discoideum)
Phase I - Functionalization of compounds (Dictyostelium discoideum)
FMO oxidises nucleophiles (Dictyostelium discoideum)
FMO3:FAD N-oxidises TMA to TMAO (Dictyostelium discoideum)
TMA [endoplasmic reticulum lumen]
Metabolism (Gallus gallus)
Biological oxidations (Gallus gallus)
Phase I - Functionalization of compounds (Gallus gallus)
FMO oxidises nucleophiles (Gallus gallus)
FMO3:FAD N-oxidises TMA to TMAO (Gallus gallus)
TMA [endoplasmic reticulum lumen]
Disease (Homo sapiens)
Diseases of metabolism (Homo sapiens)
Metabolic disorders of biological oxidation enzymes (Homo sapiens)
Defective FMO3 causes TMAU (Homo sapiens)
Defective FMO3 does not N-oxidise TMA (Homo sapiens)
TMA [endoplasmic reticulum lumen]
Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
FMO oxidises nucleophiles (Homo sapiens)
FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)
TMA [endoplasmic reticulum lumen]
Metabolism (Mus musculus)
Biological oxidations (Mus musculus)
Phase I - Functionalization of compounds (Mus musculus)
FMO oxidises nucleophiles (Mus musculus)
FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)
TMA [endoplasmic reticulum lumen]
Metabolism (Rattus norvegicus)
Biological oxidations (Rattus norvegicus)
Phase I - Functionalization of compounds (Rattus norvegicus)
FMO oxidises nucleophiles (Rattus norvegicus)
FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)
TMA [endoplasmic reticulum lumen]
Metabolism (Sus scrofa)
Biological oxidations (Sus scrofa)
Phase I - Functionalization of compounds (Sus scrofa)
FMO oxidises nucleophiles (Sus scrofa)
FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)
TMA [endoplasmic reticulum lumen]
Metabolism (Xenopus tropicalis)
Biological oxidations (Xenopus tropicalis)
Phase I - Functionalization of compounds (Xenopus tropicalis)
FMO oxidises nucleophiles (Xenopus tropicalis)
FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)
TMA [endoplasmic reticulum lumen]
External Reference Information
External Reference
trimethylamine [ChEBI:18139]
Participates
as an input of
Defective FMO3 does not N-oxidise TMA (Homo sapiens)
FMO3:FAD N-oxidises TMA to TMAO (Dictyostelium discoideum)
FMO3:FAD N-oxidises TMA to TMAO (Caenorhabditis elegans)
FMO3:FAD N-oxidises TMA to TMAO (Gallus gallus)
FMO3:FAD N-oxidises TMA to TMAO (Xenopus tropicalis)
FMO3:FAD N-oxidises TMA to TMAO (Danio rerio)
FMO3:FAD N-oxidises TMA to TMAO (Sus scrofa)
FMO3:FAD N-oxidises TMA to TMAO (Bos taurus)
FMO3:FAD N-oxidises TMA to TMAO (Canis familiaris)
FMO3:FAD N-oxidises TMA to TMAO (Rattus norvegicus)
FMO3:FAD N-oxidises TMA to TMAO (Mus musculus)
FMO3:FAD N-oxidises TMA to TMAO (Homo sapiens)
Cross References
Guide to Pharmacology - Ligands
5521
COMPOUND
C00565
PubChem Substance
8143874
HMDB Metabolite
HMDB0000906
ZINC
000008216125
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