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ACA [cytosol]
Stable Identifier
R-ALL-29666
Type
Chemical Compound [SimpleEntity]
Compartment
cytosol
Synonyms
3-Oxobutanoate, acetoacetate
Locations in the PathwayBrowser
for Species:
Homo sapiens
Bos taurus
Caenorhabditis elegans
Canis familiaris
Danio rerio
Dictyostelium discoideum
Drosophila melanogaster
Gallus gallus
Mus musculus
Rattus norvegicus
Sus scrofa
Xenopus tropicalis
Expand all
Drug ADME (Bos taurus)
Aspirin ADME (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Bos taurus)
Metabolism of amino acids and derivatives (Bos taurus)
Phenylalanine and tyrosine metabolism (Bos taurus)
Tyrosine catabolism (Bos taurus)
FAH cleaves 4FAA (Bos taurus)
ACA [cytosol]
Metabolism of lipids (Bos taurus)
Ketone body metabolism (Bos taurus)
Synthesis of Ketone Bodies (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Bos taurus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)
ACA [cytosol]
Transport of small molecules (Bos taurus)
SLC-mediated transmembrane transport (Bos taurus)
Transport of bile salts and organic acids, metal ions and amine compounds (Bos taurus)
Proton-coupled monocarboxylate transport (Bos taurus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Bos taurus)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Caenorhabditis elegans)
Aspirin ADME (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Caenorhabditis elegans)
Metabolism of amino acids and derivatives (Caenorhabditis elegans)
Phenylalanine and tyrosine metabolism (Caenorhabditis elegans)
Tyrosine catabolism (Caenorhabditis elegans)
FAH cleaves 4FAA (Caenorhabditis elegans)
ACA [cytosol]
Metabolism of lipids (Caenorhabditis elegans)
Ketone body metabolism (Caenorhabditis elegans)
Synthesis of Ketone Bodies (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)
ACA [cytosol]
Transport of small molecules (Caenorhabditis elegans)
SLC-mediated transmembrane transport (Caenorhabditis elegans)
Transport of bile salts and organic acids, metal ions and amine compounds (Caenorhabditis elegans)
Proton-coupled monocarboxylate transport (Caenorhabditis elegans)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Caenorhabditis elegans)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Canis familiaris)
Aspirin ADME (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Canis familiaris)
Metabolism of amino acids and derivatives (Canis familiaris)
Phenylalanine and tyrosine metabolism (Canis familiaris)
Tyrosine catabolism (Canis familiaris)
FAH cleaves 4FAA (Canis familiaris)
ACA [cytosol]
Metabolism of lipids (Canis familiaris)
Ketone body metabolism (Canis familiaris)
Synthesis of Ketone Bodies (Canis familiaris)
BDH2 dehydrogenates 3HBA (Canis familiaris)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)
ACA [cytosol]
Transport of small molecules (Canis familiaris)
SLC-mediated transmembrane transport (Canis familiaris)
Transport of bile salts and organic acids, metal ions and amine compounds (Canis familiaris)
Proton-coupled monocarboxylate transport (Canis familiaris)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Canis familiaris)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Danio rerio)
Metabolism of lipids (Danio rerio)
Ketone body metabolism (Danio rerio)
Synthesis of Ketone Bodies (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Danio rerio)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)
ACA [cytosol]
Transport of small molecules (Danio rerio)
SLC-mediated transmembrane transport (Danio rerio)
Transport of bile salts and organic acids, metal ions and amine compounds (Danio rerio)
Proton-coupled monocarboxylate transport (Danio rerio)
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Danio rerio)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Dictyostelium discoideum)
Metabolism of amino acids and derivatives (Dictyostelium discoideum)
Phenylalanine and tyrosine metabolism (Dictyostelium discoideum)
Tyrosine catabolism (Dictyostelium discoideum)
FAH cleaves 4FAA (Dictyostelium discoideum)
ACA [cytosol]
Metabolism of lipids (Dictyostelium discoideum)
Ketone body metabolism (Dictyostelium discoideum)
Synthesis of Ketone Bodies (Dictyostelium discoideum)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)
ACA [cytosol]
Drug ADME (Drosophila melanogaster)
Aspirin ADME (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Drosophila melanogaster)
Metabolism of amino acids and derivatives (Drosophila melanogaster)
Phenylalanine and tyrosine metabolism (Drosophila melanogaster)
Tyrosine catabolism (Drosophila melanogaster)
FAH cleaves 4FAA (Drosophila melanogaster)
ACA [cytosol]
Metabolism of lipids (Drosophila melanogaster)
Ketone body metabolism (Drosophila melanogaster)
Synthesis of Ketone Bodies (Drosophila melanogaster)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)
ACA [cytosol]
Transport of small molecules (Drosophila melanogaster)
SLC-mediated transmembrane transport (Drosophila melanogaster)
Transport of bile salts and organic acids, metal ions and amine compounds (Drosophila melanogaster)
Proton-coupled monocarboxylate transport (Drosophila melanogaster)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Drosophila melanogaster)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Gallus gallus)
Aspirin ADME (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Gallus gallus)
Metabolism of amino acids and derivatives (Gallus gallus)
Phenylalanine and tyrosine metabolism (Gallus gallus)
Tyrosine catabolism (Gallus gallus)
FAH cleaves 4FAA (Gallus gallus)
ACA [cytosol]
Metabolism of lipids (Gallus gallus)
Ketone body metabolism (Gallus gallus)
Synthesis of Ketone Bodies (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Gallus gallus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Gallus gallus)
ACA [cytosol]
Transport of small molecules (Gallus gallus)
SLC-mediated transmembrane transport (Gallus gallus)
Transport of bile salts and organic acids, metal ions and amine compounds (Gallus gallus)
Proton-coupled monocarboxylate transport (Gallus gallus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Gallus gallus)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Homo sapiens)
Aspirin ADME (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Phenylalanine and tyrosine metabolism (Homo sapiens)
Tyrosine catabolism (Homo sapiens)
FAH cleaves 4FAA (Homo sapiens)
ACA [cytosol]
Metabolism of lipids (Homo sapiens)
Ketone body metabolism (Homo sapiens)
Synthesis of Ketone Bodies (Homo sapiens)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Homo sapiens)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)
ACA [cytosol]
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Proton-coupled monocarboxylate transport (Homo sapiens)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Homo sapiens)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Mus musculus)
Aspirin ADME (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Mus musculus)
Metabolism of amino acids and derivatives (Mus musculus)
Phenylalanine and tyrosine metabolism (Mus musculus)
Tyrosine catabolism (Mus musculus)
FAH cleaves 4FAA (Mus musculus)
ACA [cytosol]
Metabolism of lipids (Mus musculus)
Ketone body metabolism (Mus musculus)
Synthesis of Ketone Bodies (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Mus musculus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)
ACA [cytosol]
Transport of small molecules (Mus musculus)
SLC-mediated transmembrane transport (Mus musculus)
Transport of bile salts and organic acids, metal ions and amine compounds (Mus musculus)
Proton-coupled monocarboxylate transport (Mus musculus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Mus musculus)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Rattus norvegicus)
Aspirin ADME (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Rattus norvegicus)
Metabolism of amino acids and derivatives (Rattus norvegicus)
Phenylalanine and tyrosine metabolism (Rattus norvegicus)
Tyrosine catabolism (Rattus norvegicus)
FAH cleaves 4FAA (Rattus norvegicus)
ACA [cytosol]
Metabolism of lipids (Rattus norvegicus)
Ketone body metabolism (Rattus norvegicus)
Synthesis of Ketone Bodies (Rattus norvegicus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)
ACA [cytosol]
Transport of small molecules (Rattus norvegicus)
SLC-mediated transmembrane transport (Rattus norvegicus)
Transport of bile salts and organic acids, metal ions and amine compounds (Rattus norvegicus)
Proton-coupled monocarboxylate transport (Rattus norvegicus)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Rattus norvegicus)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Sus scrofa)
Aspirin ADME (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Sus scrofa)
Metabolism of amino acids and derivatives (Sus scrofa)
Phenylalanine and tyrosine metabolism (Sus scrofa)
Tyrosine catabolism (Sus scrofa)
FAH cleaves 4FAA (Sus scrofa)
ACA [cytosol]
Metabolism of lipids (Sus scrofa)
Ketone body metabolism (Sus scrofa)
Synthesis of Ketone Bodies (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
ACA [cytosol]
BDH2 dehydrogenates 3HBA (Sus scrofa)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)
ACA [cytosol]
Transport of small molecules (Sus scrofa)
SLC-mediated transmembrane transport (Sus scrofa)
Transport of bile salts and organic acids, metal ions and amine compounds (Sus scrofa)
Proton-coupled monocarboxylate transport (Sus scrofa)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [cytosol]
ACA [cytosol]
SLC16A3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol (Sus scrofa)
MCT substrates [cytosol]
ACA [cytosol]
Drug ADME (Xenopus tropicalis)
Aspirin ADME (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
MCT substrates [cytosol]
ACA [cytosol]
Metabolism (Xenopus tropicalis)
Metabolism of amino acids and derivatives (Xenopus tropicalis)
Phenylalanine and tyrosine metabolism (Xenopus tropicalis)
Tyrosine catabolism (Xenopus tropicalis)
FAH cleaves 4FAA (Xenopus tropicalis)
ACA [cytosol]
Metabolism of lipids (Xenopus tropicalis)
Ketone body metabolism (Xenopus tropicalis)
Synthesis of Ketone Bodies (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
ACA [cytosol]
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)
ACA [cytosol]
Transport of small molecules (Xenopus tropicalis)
SLC-mediated transmembrane transport (Xenopus tropicalis)
Transport of bile salts and organic acids, metal ions and amine compounds (Xenopus tropicalis)
Proton-coupled monocarboxylate transport (Xenopus tropicalis)
SLC16A1:BSG cotransports monocarboxylates, H+ from extracellular region to cytosol (Xenopus tropicalis)
MCT substrates [cytosol]
ACA [cytosol]
External Reference Information
External Reference
acetoacetate [ChEBI:13705]
Participates
as an input of
AACS ligates CoA-SH to ACA, forming ACA-CoA (Caenorhabditis elegans)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Gallus gallus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Xenopus tropicalis)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Danio rerio)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Sus scrofa)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Bos taurus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Rattus norvegicus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Mus musculus)
AACS ligates CoA-SH to ACA, forming ACA-CoA (Homo sapiens)
as an output of
BDH2 dehydrogenates 3HBA (Gallus gallus)
BDH2 dehydrogenates 3HBA (Danio rerio)
BDH2 dehydrogenates 3HBA (Sus scrofa)
BDH2 dehydrogenates 3HBA (Bos taurus)
BDH2 dehydrogenates 3HBA (Canis familiaris)
BDH2 dehydrogenates 3HBA (Rattus norvegicus)
BDH2 dehydrogenates 3HBA (Mus musculus)
BDH2 dehydrogenates 3HBA (Homo sapiens)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Dictyostelium discoideum)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Caenorhabditis elegans)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Drosophila melanogaster)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Gallus gallus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Xenopus tropicalis)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Danio rerio)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Sus scrofa)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Bos taurus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Canis familiaris)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Rattus norvegicus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Mus musculus)
HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA (Homo sapiens)
FAH cleaves 4FAA (Dictyostelium discoideum)
FAH cleaves 4FAA (Caenorhabditis elegans)
FAH cleaves 4FAA (Drosophila melanogaster)
FAH cleaves 4FAA (Gallus gallus)
FAH cleaves 4FAA (Xenopus tropicalis)
FAH cleaves 4FAA (Sus scrofa)
FAH cleaves 4FAA (Bos taurus)
FAH cleaves 4FAA (Rattus norvegicus)
FAH cleaves 4FAA (Mus musculus)
FAH cleaves 4FAA (Homo sapiens)
FAH cleaves 4FAA (Canis familiaris)
as a member of
MCT substrates [cytosol]
Cross References
COMPOUND
C00164
HMDB Metabolite
HMDB0304256
ZINC
000000895089
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