New and Updated Topics and Pathways. Topics with new or revised pathways in this release include Autophagy (Macroautophagy), Cell Cycle (Cyclin A/B1/B2 associated events during G2/M transition, Regulation of PLK1 Activity at G2/M Transition), Cellular responses to stimuli (Heme signaling), Chromatin organization (ATP-dependent chromatin remodellers), Circadian Clock, Developmental Biology (Developmental Cell Lineages of the Exocrine Pancreas, Developmental Lineage of Multipotent Pancreatic Progenitor Cells, Developmental Lineage of Pancreatic Ductal Cells), Disease (Diseases associated with glycosylation precursor biosynthesis), Immune system (Class I MHC mediated antigen processing & presentation), Metabolism (Aspartate and asparagine metabolism, Cysteine formation from homocysteine, Degradation of cysteine and homocysteine, Formation of selenosugars for excretion, Galactose catabolism, Glycerophospholipid biosynthesis, Glycogen breakdown (glycogenolysis), Glycolysis, Glyoxylate metabolism and glycine degradation, Lysine catabolism, Metabolism of ingested H2SeO4 and H2SeO3 into H2Se, Metabolism of ingested SeMet, Sec, MeSec into H2Se, Methionine salvage pathway, OADH complex synthesizes glutaryl-CoA from 2-OA, PPARA activates gene expression, Proline catabolism, Selenocysteine synthesis, Serine metabolism, Threonine catabolism, and Tryptophan catabolism), Metabolism of proteins (O-linked glycosylation and Synthesis of dolichyl-phosphate), and Metabolism of RNA (Nuclear RNA decay).
New and Updated Illustrations. New or revised Illustrations with embedded navigation features have been created for Aerobic respiration and respiratory electron transport, ATP-dependent chromatin remodellers, Chromatin organization, Circadian clock, Developmental Cell Lineages, Developmental Lineages of Exocrine Pancreas, Diseases associated with glycosylation precursor biosynthesis, Metabolism of RNA, and Parasite infection.
Thanks to our Contributors. Urs Albrecht, Alan Alwakeel, Emily C Dykhuizen, David P Hill, Bernard Khor, Nancy T Li, and Aziz Sancar are our external reviewers.
Annotation Statistics. Reactome comprises 15,672 human reactions organized into 2,769 pathways involving 31168 proteins and modified forms of proteins encoded by 11,356 different human genes, 15,486 complexes, 2,130 small molecules, and 1,057 drugs. These annotations are supported by 40,321 literature references. We have projected these reactions onto 80,248 orthologous proteins, creating 19,963 orthologous pathways in 14 non-human species. Version 92 has annotations for 4,947 protein variants (mutated proteins) and their post-translationally modified forms, derived from 392 proteins, which have contributed to the annotation of 1,809 disease-specific reactions and 747 pathways.
Other news. In our next version (v93) of Reactome, we will be migrating our Docker image hosting from DockerHub to AWS Elastic Container Registry (ECR). Going forward, users will be able to pull our container images from AWS ECR. This transition ensures improved reliability, security, and integration with our cloud infrastructure. Updated instructions for accessing the images will be provided in our documentation.
Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and access programmatically through our Content and Analysis Services. The ReactomeFIViz app and ReactomeGSA package provide tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context.
Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The EMBL - European Bioinformatics Institute. Reactome is both an ELIXIR Core Data Resource and a Global Core Biodata Resource. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) License applies to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art, and Branding Materials. A full description of the new and updated content is available on the Reactome website.
Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!
For more information: If you have a question, want to provide feedback, or are interested in collaborating with us to annotate a topic, please contact us at This email address is being protected from spambots. You need JavaScript enabled to view it..
