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New and Updated Topics and Pathways. Topics with new or revised pathways in V77 include Disease (Defective HDR through Homologous Recombination (HRR) Due to PALB2 Loss of Function, Defective pyroptosis, Loss of Function of TP53 in Cancer, Maturation of nucleoprotein, and Signaling by ALK in cancer), DNA repair (Homologous DNA Pairing and Strand Exchange), Programmed Cell Death (Pyroptosis), and Signal transduction (Fc epsilon receptor (FCERI) signaling, RHOD GTPase Cycle, RHOF GTPase Cycle, RHOU GTPase Cycle, RHOV GTPase Cycle, and Signaling by ALK).

New and Updated Illustrations. Illustrations with embedded navigation features have been added or revised for Cellular response to chemical stressCellular response to starvation, Cellular responses to stress, Diseases of glycosylation, Diseases of Signal Transduction by growth factor receptors and second messengers, HIV Infection, Metabolism of proteins, Oncogenic MAPK signaling, Regulated Necrosis, Signaling by ALK in Cancer, Signaling by FGFR in Disease, Signaling by KIT in Disease, Signaling by receptor tyrosine kinases, and Signaling by Rho GTPases.

Thanks to our Contributors. Our external reviewers are Marcio Luis Acencio, Mariano Bisbal, Giorgio Inghirami, Anna Niarakis, Helmut Pospiech, Kazuyasu Sakaguchi, Mikhail V ShepelevFeng Shao, and Robert Winqvist.

Annotation Statistics. Reactome comprises 13,827 human reactions organized into 2,536 pathways involving 11,374 proteins and modified forms of proteins encoded by 11,084 different human genes, 13,662 complexes, 1,857 small molecules, and 432 drugs. These annotations are supported by 33,752 literature references. We have projected these reactions onto 78,539 orthologous proteins, creating 18,659 orthologous pathways in 15 non-human species. Version 77 has annotations for 4,464 protein variants (mutated proteins) and their post-translationally modified forms, derived from 347 proteins, which have been used to annotate disease-specific reactions and pathways.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeGSA package provides tools for multi-omics data analysis. The idg.reactome.org Web Portal provides a collection of web-based tools to help researchers place understudied proteins in a pathway context. 

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

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