As part of the Cutting Edge Informatics Tools (CEIT) for the Illuminating the Druggable (IDG) Program, the Reactome group has built a new tool, the Reactome IDG Portal, that utilizes the Reactome knowledgebase to systematically illuminate interactions of dark proteins with other proteins and biological entities, allowing evaluation of these understudied proteins via their localizations and potential interactions, and facilitating the design of experiments to test their functions. The portal enables users to:

• Search any gene and view its location in Reactome’s pathways based on manual annotation or interactions via one-hop pairwise relationships. 
• Convert biochemical reaction-based diagrams into simple pairwise networks.
• View scored interacting pathways based on functional interactions predicted from a random forest model trained with 106 features. 
• Construct new overlays and visualizations for protein-protein pairwise relationships or drug-target interactions.
• Use an extended diagram viewer to visualize protein knowledge levels, and overlay multiple tissue-specific expression values from 19 data sources from Target Central Resource Database (TCRD).

Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, New York University Langone Medical Center, Oregon Health and Science University, and The European Bioinformatics Institute. Reactome data and software are distributed under the terms of the Creative Commons Attribution 4.0 License. A full description of the new and updated content is available on the Reactome website. Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more.

The Illuminating the Druggable Genome (IDG) Program, launched by the National Institutes of Health (NIH) Common Fund, is a multidisciplinary project to improve the scientific understanding of understudied members of three key protein families: non-olfactory G-protein-coupled receptors (GPCRs), ion channels and protein kinases. The overall goal of the IDG Program is to catalyze research in areas of biology that are currently understudied but that have high potential to impact human health. Follow us on Twitter: @DruggableGenome to receive updates about the program.