infectious events

New and Updated Pathways. In version 72, topics with new or revised pathways include Autophagy (Pexophagy), Cell Cycle (Nuclear Envelope Reassembly), Developmental Biology (EGR2- and SOX10-mediated initiation of Schwann cell myelination), Disease (Signaling by ERBB2 in CancerSignaling by ERBB2 ECD MutantsSignaling by ERBB2 TMD/JMD MutantsSignaling by PDGFR in disease, and Leishmania infection),  and Signal Transduction (NGF-stimulated transcription and Drug-mediated inhibition of ERBB2 signaling).

New and Updated Illustrations. Illustrations with embedded navigation features have been added or revised for DiseaseInfectious disease, and Leishmania infection and Developmental Biology. New static illustrations are now available for Regulation of commissural axon pathfinding by SLIT and ROBOSignaling by ROBO receptors, and TCR signaling.

Thanks to our Contributors. John Aletta, Ron BoseLarry Gerace, David Gregory, Carman Ip, Rama Krishna Kancha, Therese Kinsella, Anagha Krishna, Xiangguo Liu, Anne Martin, Emmanouil Metzakopian, Adam MillerEamon MulvaneyKirk Staschke, and Shun Yao are our external reviewers.

Annotation Statistics. Reactome comprises 12,986 human reactions organized into 2,362 pathways involving 11,096 proteins and modified forms of proteins encoded by 10,908 different human genes, 12,728 complexes, 1,865 small molecules, and 237 drugs. These annotations are supported by 31,237 literature references. We have projected these reactions onto 83,698 orthologous proteins, creating 18,996 orthologous pathways in 15 non-human species. Version 72 has annotations for 1,890 protein variants (mutated proteins) and their post-translationally modified forms, derived from 315 proteins, which have been used to annotate disease-specific reactions and pathways.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

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