FA Metabolism

New and Updated Pathways. In version 71, Topics with new or revised pathways include Autophagy (Aggrephagy), Cell Cycle (EML4 and NUDC in mitotic spindle formation), Cellular responses to external stimuli (EIK2AK4 (GCN2) modifies gene expression in response to amino acid deficiency and Response of EIF2AK1 (HRI) to heme deficiency), Disease (Defective base excision repair associated with OGG1, HCMV infection, Infection with Mycobacterium tuberculosis, and Signaling by ERBB2 in Cancer), Generic transcription pathway (Transcriptional regulation by VENTX), Metabolism (Metabolism of porphyrins), and Signal Transduction (Drug-mediated inhibition of ERBB2 signaling).

New and Updated Illustrations. Biosynthesis of specialized proresolving mediators (SPMs), Fatty acid metabolism, Metabolism, Metabolism of lipids, Metabolism of vitamins and cofactors, and Phospholipid metabolism have new Illustrations with embedded navigation features. Cellular responses to stress, Digestion and absorption, and Autophagy have revised Illustrations with embedded navigation features.

Thanks to our Contributors. Ralf Stephan is our external author. Susanne Bechstedt, Istvan Boldogh, Alain Bruhat, Patrizia Caposio, Jane-Jane Chen, Armin Deffur, Andrew Fry, Rama Krishna Kancha, Kellie Lucken, Emmanouil Metzakopian, Laura O'Regan, Daniel Streblow, Naidu M Vegi, Spiros Vlahopoulos, and Robert Wilkinson are our external reviewers.

Annotation Statistics. Reactome comprises 12,608 human reactions organized into 2,282 pathways involving 11,053 proteins and modified forms of proteins encoded by 10,870 different human genes, 12,489 complexes, 1,863 small molecules, and 225 drugs. These annotations are supported by 30,721 literature references. We have projected these reactions onto 83,392 orthologous proteins, creating 18,697 orthologous pathways in 15 non-human species. Version 71 has annotations for 1,816 protein variants (mutated proteins) and their post-translationally modified forms, derived from 310 proteins, which have been used to annotate disease-specific reactions and pathways.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

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