New and Updated Pathways. In version 70, topics with new or revised pathways include Cellular response to stress (Amino acids regulate mTORC1), Disease (Evasion of oncogene induced senescence due to p16-INK4A defects, Evasion of oxidative stress induced senescence due to p16-INK4A defects, Defective intrinsic pathway for apoptosis due to p14ARF loss of function, Evasion of oncogene induced senescence due to p14ARF defects, Evasion of oxidative stress induced senescence due to p14ARF defects), Immune System (Alpha-protein kinase 1 signaling pathway and FLT3 signaling), and Signal transduction (NR1H2 and NR1H3-mediated signaling).
New and Updated Illustrations. Topics with new or revised illustrations include Metabolism of amino acids and derivatives and Innate Immune System.
Thanks to our Contributors. Dorothy Bennett, Kendall Condon, Carolyn Cummins, Nicholas Hayward, Sunil Joshi, Vaishnavi Nathan, Joyce Repa, Helen Rizos, David Sabatini, and Feng Shao are our external reviewers.
Annotation Statistics. Reactome comprises 12,608 human reactions organized into 2,282 pathways involving 11,040 proteins and modified forms of proteins encoded by 10,860 different human genes, 12,335 complexes, 1,856 small molecules, and 222 drugs. These annotations are supported by 30.398 literature references. We have projected these reactions onto 83,183 orthologous proteins, creating 18,679 orthologous pathways in 15 non-human species. Version 70 has annotations for 1,762 protein variants (mutated proteins) and their post-translationally modified forms, derived from 308 proteins. These have been used to annotate 536 complexes and 970 disease-specific reactions organized into 484 pathways and subpathways, and tagged with 387 Disease Ontology terms.
Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.
Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.
About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.
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