Signaling by Nuclear Receptors

New and Updated Pathways. In version V68, topics with new or revised pathways include Disease (Defective Base Excision Repair Associated with NTHL1, Defective Base Excision Repair Associated with NEIL1, and Defective Base Excision Repair Associated with NEIL3), Metabolism (Blood group systems biosynthesis), Neuronal System (Assembly and cell surface presentation of NMDA receptors), Protein localization (Class I peroxisomal membrane protein import and Insertion of tail-anchored proteins into the endoplasmic reticulum membrane), and Signal Transduction (Non-genomic estrogen signaling).

New Illustrations. Illustrations with embedded navigation features are now available for Signaling by Non-Receptor Tyrosine Kinases, Signaling by Nuclear Receptors, and SUMO E3 ligases SUMOylate target proteins.

Thanks to our Contributors. Subhrajit Bhattacharya, Chad R Camp, Richarda de Voer, Evelina DeLaurentis, Paul W Doetsch, Ákos Farkas, Marc Fransen, Roland Kuiper, Ellis R Levin, Taei Matsui, Huaiyu Mi, Barbara Rivera, Harini Sampath, Blanche Schwappach, Ralf Stephan, Stephen F Traynelis, and Jia Zhou are our external reviewers.

Annotation Statistics. Reactome comprises 12,416 human reactions organized into 2,255 pathways involving 11,000 proteins and modified forms of proteins encoded by 10,825 different human genes, 1,854 small molecules, and 202 drugs. These annotations are supported by 29,885 literature references. We have projected these reactions onto 81,875 orthologous proteins, creating 18,505 orthologous pathways in 15 non-human species. Version 68 has annotations for 1,416 protein variants (mutated proteins) and their post-translationally modified forms, derived from 304 proteins. These have been used to annotate 532 complexes and 966 disease-specific reactions organized into 472 pathways and subpathways, and tagged with 349 Disease Ontology terms.

Tools and Data. Our services and software tools are designed for biologists, bioinformaticians, and software developers. Pathway data is available to view in our Pathway Browser, to analyze your own dataset, to download, and to access programmatically through our Content and Analysis Services. The ReactomeFIViz app for Cytoscape provides tools to find pathways and network patterns related to cancer and other types of diseases.

Documentation and Training. Visit our online User Guide to access documentation supporting pathway analysis of experimental data. The Developer's Zone provides detailed documentation regarding our software, tools, and web services. Training and learning materials can be found here.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

Follow us on Twitter: @reactome to get frequent updates about new and updated pathways, feature updates, and more!

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