ER to Golgi

New and Updated Pathways. In version V67, topics with new or revised pathways include Gene Expression (FOXO-mediated transcription), Immune Response (ROS, RNS production in phagocytes), Neuronal System (Activation of NMDA receptors and postsynaptic events), Programmed Cell Death (Apoptotic factor-mediated response), and Signal Transduction (GPCR downstream signaling and RHO GTPase activate NADPH oxidases).

New Illustrations. Illustrations with embedded navigation features are now available for ER to Golgi Anterograde Transport, Expression and Processing of Neurotrophins, and Signaling by NTRKs.

Thanks to our Contributors. Enrico  Bertaggia, Timothy Donlon, Kasper Hansen, Oliver NĂ¼sse, and Feng Yi are our external reviewers.

Annotation Statistics. Reactome comprises 12,788 human reactions organized into 2,256 pathways involving 11,066 proteins and modified forms of proteins encoded by 10,792 different human genes, 1,827 small molecules, and 155 drugs. These annotations are supported by 29,454 literature references. We have projected these reactions onto 139,298 orthologous proteins, creating 21,374 orthologous pathways in 18 non-human species. Version 67 has annotations for 1,564 protein variants (mutated proteins) and their post-translationally modified forms, derived from 299 proteins. These have been used to annotate 506 complexes and 962 disease-specific reactions organized into 467 pathways and subpathways, and tagged with 342 Disease Ontology terms.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactome are distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

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