protein localization

New and Updated Pathways. In version 66, topics with new or revised pathways includeDisease (Loss of function of MECP2 in Rett syndrome and Defective Base Excision Repair Associated with MUTYH), Gene Expression (Transcriptional regulation by MECP2), Immune Response (OAS antiviral response), Metabolism of proteins (SUMOylation of DNA methylation proteins, SUMOylation of immune response proteins, SUMOylation of intracellular receptors, SUMOylation of SUMOylation proteins, SUMOylation of transcription cofactors, and SUMOylation of ubiquitinylation proteins), and Signal Transduction (Signaling by Erythropoietin).

Thanks to our Contributors. John Christodoulou, Rahul Krishnaraj, Kathy L McGraw, Marco Meras-Rios, Yusaku Nakabeppu, Einari Niskanen, Robert H Silverman, and J├╝rgen Wienands are our external reviewers.

New Ilustrations. Illustrations with embedded navigation features are now available for DNA replication and Protein localization.

Annotation Statistics. Reactome comprises 12,047 human reactions organized into 2,244 pathways involving 11,049 proteins encoded by 10,870 different human genes, 1,948 small molecules, and 11,823 complexes. New in this release are annotations of the functions of 139 drugs, 3 of them proteins and 136 small molecules. These annotations are supported by 28,829 literature references. We have projected these reactions onto 139,072 orthologous proteins, creating 21,283 orthologous pathways in 18 non-human species. Version 66 has annotations for 1,391 protein variants (mutated proteins) and their post-translationally modified forms, derived from 293 proteins, which have been used to annotate disease-specific complexes, reactions and pathways.

About the Reactome Project. Reactome is a collaboration between groups at the Ontario Institute for Cancer Research, Oregon Health and Science University, New York University Langone Medical Center, and The European Bioinformatics Institute. Reactome annotation files and interaction data derived from Reactomeare distributed under a Creative Commons Public Domain (CC0 1.0 Universal) Licence. A Creative Commons Attribution 4.0 International (CC BY 4.0) Licence will apply to all software and code, database data dumps, and Pathway Illustrations (Enhanced High-Level Diagrams), Icon Library, Art and Branding Materials. A full description of the new and updated content is available on the Reactome website.

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