Meet the React-to-Me AI Chatbot! Your new guide to Reactome. Whether you’re looking for specific genes and pathways or just browsing, our AI Chatbot is here to assist you.

CHAT

Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

[February 1, 2025] In the July 2024 issue of Briefings in Bioinformatics, Yi et al. report on The Biochemical Pathway Prediction (BPP) framework, a predictive analytical tool that utilizes various graph representation learning models to predict attributes and links in biochemical pathways. BPP provides two pieces of information: link prediction, which identifies potential connections between entities and reactions, and attribute prediction, which predicts missing attributes of nodes. The BPP framework was used to evaluate datasets derived from Reactome pathway data (version 75 to version 85), specifically identifying a key receptor, glycosylated-ACE2, instrumental in the SARS-CoV-2 invasion process.

ARCHIVE

Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Version 91 released on December 4, 2024

2,751

Human Pathways

15,591

Reactions

11,541

Proteins

2,125

Small Molecules

1,057

Drugs

39,806

Literature References

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