Reactome: A Curated Pathway Database

Version 3 of the FlyReactome Knowledgebase has been released

Version 3 of the FlyReactome Knowledgebase has been released and is accessible at

FlyReactome (Mark Williams and Michael Ashburner at the Dept. of Genetics, Univ. of Cambridge), developed in collaboration with the Reactome Knowledgebase group (, covers Drosophila melanogaster signalling processes. The information in FlyReactome is provided by expert biological researchers and edited and maintained by the FlyReactome staff. New material is peer-reviewed and revised as necessary before publication to the web. FlyReactome entries are linked to corresponding ones in FlyBase, UniProt, NCBI (GeneID and RefSeq), Ensembl, BioGPS, CTD, KEGG (Genes and Compound), ChEBI, PubMed and Gene Ontology (GO).

The web interface allows users to view the curated annotations of the following signalling pathways: Wingless, JAK/STAT, Imd, Toll, Hedgehog, Circadian Clock, Hippo/Warts, and Planar Cell Polarity.   The last three are new pathways released in Version 3.

An Editorial Calendar, under the Content menu, containing future and pending (awaiting review) pathways is available. A basic Search Tool is available on the front page while a more powerful Advanced Search option can be accessed from the Tools menu.

Data download including database dumps and protein-protein interaction datasets are available from the download page on the website. FlyReactome data can be exported in SMBL, Protégé, and BioPAX level 2 and level 3 formats. Like everything in FlyReactome, these downloaded and exported materials can be reused. Users can subscribe to Reactome announcement list from the webpage at

FlyReactome is seeking expert help for the review of new modules. The FlyReactome knowledgebase relies on collaborations with research biologists to construct expert consensus views of key signalling pathways, and to integrate these with other processes already in FlyReactome. If you’re interested, please contact us at

For questions and comments concerning the Reactome project in general please reply to this message or write to

-The FlyReactome project

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