Reactome: A Curated Pathway Database
Developer's Zone

Download Data

Reactome provides open-source and open-data. We have continuously supported the major open-data standards, including BioPAXPSI-MITABSBML and SBGN export formats. The Reactome data and source code continues to be publicly accessible under the terms of aCreative Commons Attribution 4.0 International License.

GitHub Repository is accessible here.

Access to our most recent data release can be found below.

Identifier mapping files:

Mapping files link the source database identifier to the lowest level pathway diagram or subset of the pathway:

Mapping files link the source database identifier to all levels of the pathway hierarchy:

Mapping files link the source database identifier to all reactions:

For more information on these mapping files, please refer to the README file.

Pathway Information:

For more information on these mapping files, please refer to the README file.

Mapping file for Reactome external identifiers:

Other Mapping Files:

Reactome Graph Database:

For more information on the installation of the Reactome Graph Database, please refer to the Get Started section of the Graph Database documentation in the Developer Guide.

MySQL dumps of Reactome databases: 

Interactions derived from Reactome pathways:

PSI-MITAB interaction files:

Tab-delimited formatted files:

For additional information, about these interaction files, please refer to the PSI-MITAB or tab-delimited format guides.

Deprecated interaction files**:

** Please note that these protein-protein interaction files will no longer be available as of Version 62.

Functional interactions (FIs) derived from Reactome, and other pathway and interaction databases:

For details about FIs, please see Wu G, Feng X, Stein L. To use these FI networks, please try our ReactomeFIViz Cytoscape app.

Pathway Diagrams and Illustrations:

Specialized data formats:

** Please note that this SBML file will no longer be available as of Version 62.

Reactome Web services

Our ContentService provides outside users with direct access to pathway data in Reactome. The Reactome pathway analysis tools are also available for integration into third party websites. For details about these web services, please see this document: Reactome Developer Guide.

Curation Software

The Curator tool is meant for use by curators to annotate biological pathways based on the Reactome schema. Please note that this tool will only work with a MySQL database using our database schema. You will need to download the Main database available from this web page. 

Reactome textbook of biological pathways and processes

The textbook files can be downloaded in PDF and RTF format. Note: RTF files may be very large, but conversion to PDF or Word generates a file that is much smaller with no loss of information.