Reactome: A Curated Pathway Database
ACVR
ACVR
Description: Activin receptors family

Curator: Bruce May
ADAM22
ADAM22
Description: Disintegrin and metalloproteinase domain-containing protein 22

Curator: Bruce May
ADAM23
ADAM23
Description: Disintegrin and metalloproteinase domain-containing protein 23

Curator: Bruce May
ADRA2A-C
ADRA2A-C
Description: Alpha-2A adrenergic receptor

Curator: Steve Jupe
AGER
AGER
Description: Receptor for advanced glycation endproducts

Curator: Steve Jupe
B7-CD28
B7-CD28
Description: Cluster of Differentiation 28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. B7 is a type of peripheral membrane protein found on activated antigen presenting cells

Curator: Steve Jupe
BCR
BCR
Description: The B-cell receptor is a transmembrane receptor protein located on the outer surface of B cells

Curator: Steve Jupe
BOC
BOC
Description: Brother of CDO

Curator: Bruce May
cadherins
cadherins
Description: Calcium-dependent adhesion proteins are a class of type-1 transmembrane proteins

Curator: Bruce May
CD40-CD40L
CD40-CD40L
Description: CD40 ligand is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells

Curator: Steve Jupe
CD95
CD95
Description: Tumor necrosis factor receptor superfamily member 6

CDON
CDON
Description: Cell adhesion molecule-related/down-regulated by oncogenes

Curator: Bruce May
CLR
CLR
Description: C-type lectin receptors comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains

Curator: Steve Jupe
CRIPTO
CRIPTO
Description: Cripto is an EGF-CFC or epidermal growth factor-CFC, which is encoded by the Cryptic family 1 gene

Curator: Bruce May
cytokine receptor
cytokine receptor
Description: Cytokine receptors are receptors that bind cytokines

Curator: Steve Jupe
DAP12
DAP12
Description: DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells

Curator: Steve Jupe
DCC
DCC
Description: Deleted in Colorectal Carcinoma is a protein which in humans is encoded by the DCC gene

Curator: Steve Jupe
FCER1
FCER1
Description: FCER1 is the high-affinity receptor for the Fc region of immunoglobulin E

Curator: Steve Jupe
FCgammaR
FCgammaR
Description: FCgammaR belong to the immunoglobulin superfamily

Curator: Steve Jupe
GFR
GFR
Description: GDNF family receptor

Curator: Steve Jupe
GPCR
GPCR
Description: G-protein-coupled receptor

Curator: Steve Jupe
GPIb-IX-V
GPIb-IX-V
Description: Glycoprotein Ib-IX-V Receptor Complex

Curator: Steve Jupe
GPVI
GPVI
Description: Platelet glycoprotein VI

Curator: Steve Jupe
growth hormone receptor
growth hormone receptor
Description: Growth hormone receptor is a protein that in humans is encoded by the GHR gene

Curator: Steve Jupe
ICAM3
ICAM3
Description: Intercellular adhesion molecule 3 is a protein that in humans is encoded by the ICAM3 gene

Curator: Steve Jupe
IL1BR
IL1BR
Description: Interleukin 1B receptor

Curator: Steve Jupe
IL2R
IL2R
Description: Interleukin 2 receptor

Curator: Steve Jupe
IL3R
IL3R
Description: Interleukin 3 receptor

Curator: Steve Jupe
IL4R
IL4R
Description: Interleukin 4 receptor

Curator: Steve Jupe
IL6R
IL6R
Description: Interleukin 6 receptor

Curator: Steve Jupe
IL7R
IL7R
Description: Interleukin 7 receptor

Curator: Steve Jupe
IL10R
IL10R
Description: Interleukin 10 receptor

Curator: Steve Jupe
IL12R
IL12R
Description: Interleukin 12 receptor

Curator: Steve Jupe
IL13R
IL13R
Description: Interleukin 13 receptor

Curator: Steve Jupe
IL17R
IL17R
Description: Interleukin 17 receptor

Curator: Steve Jupe
integrins active
integrins active
Description: Integrins

Curator: Steve Jupe
integrins resting
integrins resting
Description: Integrins resting

Curator: Steve Jupe
JAM3
JAM3
Description: Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene

Curator: Steve Jupe
leptins
leptins
Description: Key player in the regulation of energy balance and body weight control

LGI-1
LGI-1
Description: Leucine-rich glioma-inactivated protein 1

Curator: Bruce May
MBL
MBL
Description: Mannose-binding lectin is a lectin that is instrumental in innate immunity

Curator: Steve Jupe
nuclear receptors
nuclear receptors
Description: Nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules

P-selectin
P-selectin
Description: P-selectin is a protein that in humans is encoded by the SELP gene

Curator: Steve Jupe
P2RY1
P2RY1
Description: P2Y purinoceptor 1

Curator: Steve Jupe
P2RY12
P2RY12
Description: P2Y purinoceptor 12

Curator: Steve Jupe
PAR 1 3 4
PAR 1 3 4
Description: Partitioning defective 3 homolog

Curator: Steve Jupe
prolactin receptor
prolactin receptor
Description: The prolactin receptor interacts with prolactin as a transmembrane receptor

Curator: Steve Jupe
scavenger receptor class A
scavenger receptor class A
Description: Scavenger receptors type 1 (SR-A1) and 2 (SR-A2) are trimers that preferentially bind modified LDL, either acylated (acLDL) or oxidized (oxLDL). They have a collagen-like domain, which is essential for ligand binding

Curator: Steve Jupe
scavenger receptor class B
scavenger receptor class B
Description: Scavenger receptor class B member 1 (SRB1) also known as SR-BI is a protein that in humans is encoded by the SCARB1 gene.[3] SR-BI functions as a receptor for high-density lipoprotein

Curator: Steve Jupe
scavenger receptor class D
scavenger receptor class D
Description: Scavenger receptors are a group of receptors that recognize modified low-density lipoprotein

Curator: Steve Jupe
scavenger receptor class E
scavenger receptor class E
Description: Scavenger receptors are a group of receptors that recognize modified low-density lipoprotein

Curator: Steve Jupe
scavenger receptor class G
scavenger receptor class G
Description: Scavenger receptors are a group of receptors that recognize modified low-density lipoprotein

Curator: Steve Jupe
SHR
SHR
Description: Steroid hormone receptors are generally intracellular receptors (typically cytoplasmic or nuclear) and initiate signal transduction for steroid hormones which lead to changes in gene expression over a time period of hours to days

TBXA2R
TBXA2R
Description: Thromboxane A2 receptor

Curator: Steve Jupe
TCR-MHCI
TCR-MHCI
Description: The T-cell receptor is a molecule found on the surface of T cells that is responsible for recognizing fragments of antigen as peptides bound to MHC class I in this case (major histocompatibility complex) molecules

Curator: Steve Jupe
TCR-MHCII
TCR-MHCII
Description: The T-cell receptor is a molecule found on the surface of T cells that is responsible for recognizing fragments of antigen as peptides bound to MHC class II in this case (major histocompatibility complex) molecules

Curator: Steve Jupe
TLR
TLR
Description: Toll-like receptors are single, membrane-spanning, non-catalytic receptors

Curator: Steve Jupe
TNFR1
TNFR1
Description: Tumor necrosis factor receptor superfamily member 1A

TNFR2
TNFR2
Description: Tumor necrosis factor receptor superfamily member 1B

Curator: Steve Jupe
TNFSF9-TNFRSF9
TNFSF9-TNFRSF9
Description: TNFSF9 is a type 2 transmembrane glycoprotein belonging to the TNF superfamily, expressed on activated T Lymphocytes. And tumor necrosis factor receptor superfamily member 9

Curator: Steve Jupe
TREM2
TREM2
Description: Triggering receptor expressed on myeloid cells 2 is a protein that in humans is encoded by the TREM2 gene

Curator: Steve Jupe
UNC5
UNC5
Description: UNC-5 is a receptor for netrins and uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production

Curator: Steve Jupe

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