Reactome: A Curated Pathway Database
ACVR
ACVR
Description: Activin receptors family

Curator: Bruce May
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ADAM22
ADAM22
Description: Disintegrin and metalloproteinase domain-containing protein 22

Curator: Bruce May
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ADAM23
ADAM23
Description: Disintegrin and metalloproteinase domain-containing protein 23

Curator: Bruce May
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AGER
AGER
Description: Receptor for advanced glycation endproducts

Curator: Steve Jupe
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B7-CD28
B7-CD28
Description: Cluster of Differentiation 28 is one of the proteins expressed on T cells that provide co-stimulatory signals required for T cell activation and survival. B7 is a type of peripheral membrane protein found on activated antigen presenting cells

Curator: Steve Jupe
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BCR
BCR
Description: The B-cell receptor is a transmembrane receptor protein located on the outer surface of B cells

Curator: Steve Jupe
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BOC
BOC
Description: Brother of CDO

Curator: Bruce May
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cadherins
cadherins
Description: Calcium-dependent adhesion proteins are a class of type-1 transmembrane proteins

Curator: Bruce May
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CD40-CD40L
CD40-CD40L
Description: CD40 ligand is a protein that is primarily expressed on activated T cells and is a member of the TNF superfamily of molecules. It binds to CD40 on antigen-presenting cells

Curator: Steve Jupe
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CDON
CDON
Description: Cell adhesion molecule-related/down-regulated by oncogenes

Curator: Bruce May
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CLR
CLR
Description: C-type lectin receptors comprise a large family of receptors that bind to carbohydrates in a calcium-dependent manner. The lectin activity of these receptors is mediated by conserved carbohydrate-recognition domains

Curator: Steve Jupe
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CRIPTO
CRIPTO
Description: Cripto is an EGF-CFC or epidermal growth factor-CFC, which is encoded by the Cryptic family 1 gene

Curator: Bruce May
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cytokine
cytokine
Description: Cytokines are a broad and loose category of small proteins that are important in cell signaling

Curator: Steve Jupe
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DAP12
DAP12
Description: DAP12 signaling subunits are highly conserved in evolution and associate with a large family of receptors in hematopoietic cells, including dendritic cells, plasmacytoid dendritic cells, neutrophils, basophils, eosinophils, mast cells, monocytes, macrophages, natural killer cells, and some B and T cells

Curator: Steve Jupe
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DCC
DCC
Description: Deleted in Colorectal Carcinoma is a protein which in humans is encoded by the DCC gene

Curator: Steve Jupe
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FCER1
FCER1
Description: FCER1 is the high-affinity receptor for the Fc region of immunoglobulin E

Curator: Steve Jupe
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FCgammaR
FCgammaR
Description: FCgammaR belong to the immunoglobulin superfamily

Curator: Steve Jupe
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growth hormone receptor
growth hormone receptor
Description: Growth hormone receptor is a protein that in humans is encoded by the GHR gene

Curator: Steve Jupe
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ICAM3
ICAM3
Description: Intercellular adhesion molecule 3 is a protein that in humans is encoded by the ICAM3 gene

Curator: Steve Jupe
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IL1BR
IL1BR
Description: Interleukin 1B receptor

Curator: Steve Jupe
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IL2R
IL2R
Description: Interleukin 2 receptor

Curator: Steve Jupe
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IL3R
IL3R
Description: Interleukin 3 receptor

Curator: Steve Jupe
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IL4R
IL4R
Description: Interleukin 4 receptor

Curator: Steve Jupe
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IL6R
IL6R
Description: Interleukin 6 receptor

Curator: Steve Jupe
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IL7R
IL7R
Description: Interleukin 7 receptor

Curator: Steve Jupe
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IL10R
IL10R
Description: Interleukin 10 receptor

Curator: Steve Jupe
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IL12R
IL12R
Description: Interleukin 12 receptor

Curator: Steve Jupe
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IL13R
IL13R
Description: Interleukin 13 receptor

Curator: Steve Jupe
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IL17R
IL17R
Description: Interleukin 17 receptor

Curator: Steve Jupe
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IL19R
IL19R
Description: Interleukin 19 receptor

Curator: Steve Jupe
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JAM3
JAM3
Description: Junctional adhesion molecule C is a protein that in humans is encoded by the JAM3 gene

Curator: Steve Jupe
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LGI-1
LGI-1
Description: Leucine-rich glioma-inactivated protein 1

Curator: Bruce May
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MBL
MBL
Description: Mannose-binding lectin is a lectin that is instrumental in innate immunity

Curator: Steve Jupe
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P-selectin
P-selectin
Description: P-selectin is a protein that in humans is encoded by the SELP gene

Curator: Steve Jupe
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prolactin receptor
prolactin receptor
Description: The prolactin receptor interacts with prolactin as a transmembrane receptor

Curator: Steve Jupe
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TCR-MHCI
TCR-MHCI
Description: The T-cell receptor is a molecule found on the surface of T cells that is responsible for recognizing fragments of antigen as peptides bound to MHC class I in this case (major histocompatibility complex) molecules

Curator: Steve Jupe
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TCR-MHCII
TCR-MHCII
Description: The T-cell receptor is a molecule found on the surface of T cells that is responsible for recognizing fragments of antigen as peptides bound to MHC class II in this case (major histocompatibility complex) molecules

Curator: Steve Jupe
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TLR
TLR
Description: Toll-like receptors are single, membrane-spanning, non-catalytic receptors

Curator: Steve Jupe
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TNFSF9-TNFRSF9
TNFSF9-TNFRSF9
Description: TNFSF9 is a type 2 transmembrane glycoprotein belonging to the TNF superfamily, expressed on activated T Lymphocytes. And tumor necrosis factor receptor superfamily member 9

Curator: Steve Jupe
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TREM2
TREM2
Description: Triggering receptor expressed on myeloid cells 2 is a protein that in humans is encoded by the TREM2 gene

Curator: Steve Jupe
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UNC5
UNC5
Description: UNC-5 is a receptor for netrins and uses repulsion to direct axons while the other netrin receptor UNC-40 attracts axons to the source of netrin production

Curator: Steve Jupe
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We would like to develop the EHLD library further as a community resource. If you use library elements, and design similar elements which are still missing, we would be very happy to incorporate them into the library, naming you as the author. Contact us at help@reactome.org.
The software and information contents are distributed under the terms of the Creative Commons Attribution 4.0 International License, which grants parties the non-exclusive right to use, distribute and create derivative works based on Reactome, provided that the software and information is correctly attributed to CSHL, OICR and EBI. Find more information about the license here.