Reactome: A Curated Pathway Database
ABL1
ABL1
Description: Tyrosine-protein kinase ABL1

Curator: Bruce May
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AC
AC
Description: Adenylate cyclase family

Curator: Steve Jupe
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ACT1
ACT1
Description: Ankyrin-1

Curator: Steve Jupe
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ADRA2A-C
ADRA2A-C
Description: Alpha-2A adrenergic receptor

Curator: Steve Jupe
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ANK 1 2 3
ANK 1 2 3
Description: ANK1, 2, 3

Curator: Steve Jupe
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antibody
antibody
Description: Antibody

Curator: Steve Jupe
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BIRC2-3
BIRC2-3
Description: Baculoviral IAP repeat-containing protein 2 and 3

Curator: Steve Jupe
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BNIP2
BNIP2
Description: BCL2/adenovirus E1B 19 kDa protein-interacting protein 2

Curator: Bruce May
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BRAF
BRAF
Description: Serine/threonine-protein kinase B-raf

Curator: Steve Jupe
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BTNL
BTNL
Description: Butyrophilin-like protein

Curator: Steve Jupe
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C3b
C3b
Description: Complement C3b

Curator: Steve Jupe
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C5
C5
Description: Complement C5

Curator: Steve Jupe
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C5a
C5a
Description: Complement C5a

Curator: Steve Jupe
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C5b
C5b
Description: Complement C5b

Curator: Steve Jupe
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CA4
CA4
Description: Carbonic anhydrase 4

Curator: Steve Jupe
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CALDAG GEFs
CALDAG GEFs
Description: Calcium- and diacylglycerol-regulated nucleotide exchange factor

Curator: Steve Jupe
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CALM1
CALM1
Description: Calmodulin

Curator: Steve Jupe
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CARD
CARD
Description: Caspase activation and recruitment domain

Curator: Steve Jupe
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CASK
CASK
Description: Peripheral plasma membrane protein CASK

Curator: Steve Jupe
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CD47
CD47
Description: Leukocyte surface antigen CD47

Curator: Steve Jupe
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CDC2AP
CDC2AP
Description: CDC2AP

Curator: Steve Jupe
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CDC42
CDC42
Description: Cell division control protein 42 homolog

Curator: Steve Jupe
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CRKL
CRKL
Description: Crk-like protein

Curator: Corina Duenas
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DDX58
DDX58
Description: Probable ATP-dependent RNA helicase

Curator: Steve Jupe
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DLGs
DLGs
Description: Disks large homologs

Curator: Steve Jupe
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EFHA
EFHA
Description: Ephrin type A receptor family

Curator: Steve Jupe
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EFHB
EFHB
Description: Ephrin type B receptor family

Curator: Steve Jupe
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EFNA
EFNA
Description: Ephrin A family

Curator: Steve Jupe
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EFNB
EFNB
Description: Ephrin B family

Curator: Steve Jupe
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ERKs
ERKs
Description: Mitogen-activated protein kinase 1 and 3

Curator: Steve Jupe
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FAK
FAK
Description: Focal adhesion kinase 1

Curator: Steve Jupe
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FARP2
FARP2
Description: FERM, RhoGEF and pleckstrin domain-containing protein 2

Curator: Steve Jupe
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ferritin
ferritin
Description: Ferritin is a universal intracellular protein that stores iron and releases it in a controlled fashion

Curator: Steve Jupe
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FES
FES
Description: Tyrosine-protein kinase Fes/Fps

Curator: Steve Jupe
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FGFR1
FGFR1
Description: Fibroblast growth factor receptor 1

Curator: Steve Jupe
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FIBRIN
FIBRIN
Description: Tyrosine-protein kinase Fes/Fps

Curator: Steve Jupe
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fibrinogen
fibrinogen
Description: Fibrinogen alpha chain

Curator: Steve Jupe
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FOXA2
FOXA2
Description: Hepatocyte nuclear factor 3-beta

Curator: Bruce May
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FYN
FYN
Description: Tyrosine-protein kinase Fyn

Curator: Steve Jupe
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GDNF
GDNF
Description: Glial cell line-derived neurotrophic factor

Curator: Steve Jupe
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GFR
GFR
Description: GDNF family receptor

Curator: Steve Jupe
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GKAP
GKAP
Description: G kinase-anchoring protein 1

Curator: Steve Jupe
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GPCR
GPCR
Description: G-protein-coupled receptor

Curator: Steve Jupe
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GPIb-IX-V
GPIb-IX-V
Description: Glycoprotein Ib-IX-V Receptor Complex

Curator: Steve Jupe
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GPVI
GPVI
Description: Platelet glycoprotein VI

Curator: Steve Jupe
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GRB2
GRB2
Description: Growth factor receptor-bound protein 2

Curator: Steve Jupe
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growth hormone
growth hormone
Description: Growth hormone

Curator: Steve Jupe
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hemoglobin
hemoglobin
Description: Hemoglobin subunit beta

Curator: Steve Jupe
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histone octamer 1
histone octamer 1
Description: Histone octamer

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histone octamer 2
histone octamer 2
Description: Histone octamer

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HMOX
HMOX
Description: Heme oxygenase 1

Curator: Steve Jupe
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HOMER
HOMER
Description: Homer protein homolog 1

Curator: Steve Jupe
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IFI16
IFI16
Description: Gamma-interferon-inducible protein 16

Curator: Steve Jupe
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IKK
IKK
Description: Inhibitor of nuclear factor kappa-B kinase subunit epsilon

Curator: Steve Jupe
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IL-1B
IL-1B
Description: Interleukin-1B

Curator: Steve Jupe
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IL-2
IL-2
Description: Interleukin-2

Curator: Steve Jupe
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IL-3
IL-3
Description: Interleukin-3

Curator: Steve Jupe
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IL-4
IL-4
Description: Interleukin-4

Curator: Steve Jupe
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IL-6
IL-6
Description: Interleukin-6

Curator: Steve Jupe
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IL-7
IL-7
Description: Interleukin-7

Curator: Steve Jupe
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IL-10
IL-10
Description: Interleukin-10

Curator: Steve Jupe
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IL-12
IL-12
Description: Interleukin-12

Curator: Steve Jupe
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IL-13
IL-13
Description: Interleukin-13

Curator: Steve Jupe
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IL-17
IL-17
Description: Interleukin-17

Curator: Steve Jupe
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IL-19
IL-19
Description: Interleukin-19

Curator: Steve Jupe
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IL1RAP
IL1RAP
Description: Interleukin-1 receptor accessory protein

Curator: Steve Jupe
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IL1RAPL1
IL1RAPL1
Description: Interleukin-1 receptor accessory protein-like 1

Curator: Steve Jupe
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IL generic
IL generic
Description: Interleukin family

Curator: Steve Jupe
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INSIG
INSIG
Description: Insulin-induced gene 1 protein

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integrins active
integrins active
Description: Integrins

Curator: Steve Jupe
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integrins resting
integrins resting
Description: Integrins resting

Curator: Steve Jupe
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interferon
interferon
Description: Interferons

Curator: Steve Jupe
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IRAK 1 2 4
IRAK 1 2 4
Description: Interleukin-1 receptor-associated kinases 1, 2 and 4

Curator: Steve Jupe
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IRS
IRS
Description: Insulin receptor substrate 1

Curator: Steve Jupe
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ISG15
ISG15
Description: Ubiquitin-like protein ISG15

Curator: Steve Jupe
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JAK1
JAK1
Description: Tyrosine-protein kinase JAK1

Curator: Steve Jupe
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JAK2
JAK2
Description: Tyrosine-protein kinase JAK2

Curator: Steve Jupe
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JAK3
JAK3
Description: Tyrosine-protein kinase JAK3

Curator: Steve Jupe
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JAK generic
JAK generic
Description: Janus kinase family

Curator: Steve Jupe
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KALRN
KALRN
Description: Kalirin

Curator: Steve Jupe
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L1CAM
L1CAM
Description: Neural cell adhesion molecule L1

Curator: Steve Jupe
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LARG
LARG
Description: Rho guanine nucleotide exchange factor 12

Curator: Steve Jupe
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LCK
LCK
Description: Tyrosine-protein kinase Lck

Curator: Steve Jupe
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LCP2
LCP2
Description: Lymphocyte cytosolic protein 2

Curator: Steve Jupe
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LIMK
LIMK
Description: LIM domain kinase 1

Curator: Steve Jupe
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LRR
LRR
Description: Leucine-rich repeat

Curator: Steve Jupe
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LRRTM
LRRTM
Description: Leucine-rich repeat transmembrane neuronal protein 1

Curator: Steve Jupe
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LYN
LYN
Description: Tyrosine-protein kinase Lyn

Curator: Steve Jupe
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MAC
MAC
Description: Membrane attack complex

Curator: Steve Jupe
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MAFA
MAFA
Description: Transcription factor MafA

Curator: Bruce May
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MAPK3K14
MAPK3K14
Description: Mitogen-activated protein kinase kinase kinase 14

Curator: Steve Jupe
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MAPK 1 3
MAPK 1 3
Description: Mitogen-activated protein kinase 1 and 3

Curator: Steve Jupe
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MAVS
MAVS
Description: Mitochondrial antiviral-signaling protein

Curator: Steve Jupe
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Mb
Mb
Description: Myoglobin is an iron- and oxygen-binding protein

Curator: Steve Jupe
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MB21D1
MB21D1
Description: Cyclic GMP-AMP synthase

Curator: Steve Jupe
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MEKs
MEKs
Description: Dual specificity mitogen-activated protein kinase kinase 1 and 2

Curator: Steve Jupe
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MICA
MICA
Description: MHC class I polypeptide-related sequence A

Curator: Steve Jupe
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MKK6
MKK6
Description: Dual specificity mitogen-activated protein kinase kinase 6

Curator: Steve Jupe
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MLCP
MLCP
Description: Myosin light-chain phosphatase, or myosin phosphatase, is an enzyme (specifically a serine/threonine-specific protein phosphatase) that dephosphorylates the regulatory light chain of myosin II

Curator: Steve Jupe
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MYD88
MYD88
Description: Myeloid differentiation primary response protein MyD88

Curator: Steve Jupe
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MYLK
MYLK
Description: Myosin light chain kinase, smooth muscle

Curator: Steve Jupe
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N-Ras
N-Ras
Description: GTPase NRas

Curator: Steve Jupe
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N-WASP
N-WASP
Description: Neural Wiskott-Aldrich syndrome protein

Curator: Steve Jupe
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NANOG
NANOG
Description: Homeobox protein NANOG

Curator: Bruce May
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NBD
NBD
Description: Nucleotide-binding domain

Curator: Steve Jupe
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NCAM cis
NCAM cis
Description: Neural cell adhesion molecules in cis-binding

Curator: Steve Jupe
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NCAM trans
NCAM trans
Description: Neural cell adhesion molecules in trans-binding

Curator: Steve Jupe
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NCK1
NCK1
Description: Cytoplasmic protein NCK1

Curator: Steve Jupe
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NEPH1
NEPH1
Description: Kin of IRRE-like protein 1

Curator: Steve Jupe
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NEPHS1
NEPHS1
Description: NEPHS1

Curator: Steve Jupe
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NEUROD1
NEUROD1
Description: Neurogenic differentiation factor 1

Curator: Bruce May
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NEUROG3
NEUROG3
Description: Neurogenin-3

Curator: Bruce May
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NFkappaB
NFkappaB
Description: Nuclear factor NF-kappa-B

Curator: Steve Jupe
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NGEF
NGEF
Description: Ephexin-1

Curator: Steve Jupe
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NKX2-2
NKX2-2
Description: Homeobox protein Nkx-2.2

Curator: Bruce May
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NKX6-1
NKX6-1
Description: Homeobox protein Nkx-6.1

Curator: Bruce May
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NLGN
NLGN
Description: Neuroligins

Curator: Steve Jupe
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NODAL
NODAL
Description: Nodal homolog

Curator: Bruce May
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NRP1 PLEXIN-A
NRP1 PLEXIN-A
Description: Neuropilin-1 and Plexin-A family

Curator: Steve Jupe
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NRXN
NRXN
Description: Neurexins

Curator: Steve Jupe
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NTN1
NTN1
Description: Netrin-1

Curator: Steve Jupe
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NTRK3
NTRK3
Description: NT-3 growth factor receptor

Curator: Steve Jupe
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OCT4
OCT4
Description: Octamer-binding transcription factor 4 also known as Aggeliki (POU domain, class 5, transcription factor 1) is a protein that in humans is encoded by the POU5F1 gene

Curator: Bruce May
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ONECUT1
ONECUT1
Description: Hepatocyte nuclear factor 6

Curator: Bruce May
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P2RY1
P2RY1
Description: P2Y purinoceptor 1

Curator: Steve Jupe
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P2RY12
P2RY12
Description: P2Y purinoceptor 12

Curator: Steve Jupe
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PAI1
PAI1
Description: Plasminogen activator inhibitor 1

Curator: Steve Jupe
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PAK1
PAK1
Description: Serine/threonine-protein kinase PAK 1

Curator: Steve Jupe
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PAR 1 3 4
PAR 1 3 4
Description: Partitioning defective 3 homolog

Curator: Steve Jupe
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PAX4
PAX4
Description: Paired box protein Pax-4

Curator: Bruce May
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PAX6
PAX6
Description: Paired box protein Pax-6

Curator: Bruce May
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PDX1
PDX1
Description: Pancreas/duodenum homeobox protein 1

Curator: Bruce May
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PI3K
PI3K
Description: Phosphoinositide 3-kinase

Curator: Steve Jupe
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PKC
PKC
Description: Protein kinase C

Curator: Steve Jupe
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plasmin
plasmin
Description: Plasmin

Curator: Steve Jupe
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plasminogen
plasminogen
Description: Plasminogen

Curator: Steve Jupe
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PLCbeta1
PLCbeta1
Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

Curator: Steve Jupe
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PLCepsilon1
PLCepsilon1
Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Curator: Steve Jupe
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PLCgamma1
PLCgamma1
Description: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

Curator: Steve Jupe
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podocin
podocin
Description: Podocin is a protein component of the filtration slits of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane and the filtration slits function as the filtration barrier of the kidney glomerulus

Curator: Steve Jupe
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PPAR-gamma
PPAR-gamma
Description: Peroxisome proliferator-activated receptor gamma

Curator: Bruce May
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procollagen
procollagen
Description: Pro-collagen

Curator: Steve Jupe
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prolactin
prolactin
Description: Prolactin

Curator: Steve Jupe
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pro ISG15
pro ISG15
Description: pro-ubiquitin-like protein ISG15

Curator: Steve Jupe
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PSD95
PSD95
Description: Postsynaptic density protein 95 also known as SAP-90 (synapse-associated protein 90) is a protein that in humans is encoded by the DLG4 (discs large homolog 4) gene

Curator: Bruce May
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PTPN6
PTPN6
Description: Tyrosine-protein phosphatase non-receptor type 6

Curator: Steve Jupe
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PTPN11
PTPN11
Description: Tyrosine-protein phosphatase non-receptor type 11

Curator: Steve Jupe
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PTPRD
PTPRD
Description: Receptor-type tyrosine-protein phosphatase delta

Curator: Steve Jupe
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PTPRS
PTPRS
Description: Receptor-type tyrosine-protein phosphatase S

Curator: Steve Jupe
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R-RAS
R-RAS
Description: Ras-related protein R-Ras

Curator: Steve Jupe
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RAC1
RAC1
Description: Ras-related C3 botulinum toxin substrate 1

Curator: Steve Jupe
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RAP1
RAP1
Description: Ras-related protein Rap-1

Curator: Steve Jupe
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RAR
RAR
Description: Retinoic acid receptor alpha

Curator: Bruce May
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RET
RET
Description: Proto-oncogene tyrosine-protein kinase receptor Ret

Curator: Steve Jupe
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RHOA
RHOA
Description: Transforming protein RhoA

Curator: Steve Jupe
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RICK
RICK
Description: Receptor-interacting serine/threonine-protein kinase 2

Curator: Steve Jupe
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RNA POL II
RNA POL II
Description: RNA polymerase II is protein-protein complex

Curator: Bruce May
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RND1
RND1
Description: Rho-related GTP-binding protein Rho6

Curator: Steve Jupe
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ROBO
ROBO
Description: Roundabout homolog 1

Curator: Steve Jupe
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ROCK
ROCK
Description: Rho-associated protein kinase 1

Curator: Steve Jupe
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RXR-alpha
RXR-alpha
Description: Retinoic acid receptor RXR-alpha

Curator: Bruce May
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RXR
RXR
Description: Retinoic acid receptor RXR

Curator: Bruce May
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SALM1
SALM1
Description: Leucine-rich repeat and fibronectin type-III domain-containing protein 2

Curator: Steve Jupe
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SALM3
SALM3
Description: Leucine-rich repeat and fibronectin type-III domain-containing protein 4

Curator: Steve Jupe
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SCAP
SCAP
Description: Sterol regulatory element-binding protein cleavage-activating protein

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SEMA3A
SEMA3A
Description: Semaphorin-3A

Curator: Steve Jupe
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SEMA4D PLXNB1
SEMA4D PLXNB1
Description: Semaphorin-4D and Plexin-B1

Curator: Steve Jupe
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SHANK
SHANK
Description: SH3 and multiple ankyrin repeat domains protein 1

Curator: Steve Jupe
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SHC1
SHC1
Description: SHC-transforming protein 1

Curator: Steve Jupe
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SIRPA
SIRPA
Description: Tyrosine-protein phosphatase non-receptor type substrate 1

Curator: Steve Jupe
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SLIT2
SLIT2
Description: Slit homolog 2 protein

Curator: Steve Jupe
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SLITRK
SLITRK
Description: SLIT and NTRK-like protein 1

Curator: Steve Jupe
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SMAD2 3
SMAD2 3
Description: Mothers against decapentaplegic homolog 2 and 3

Curator: Bruce May
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SMAD4
SMAD4
Description: Mothers against decapentaplegic homolog 4

Curator: Bruce May
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SOCS3
SOCS3
Description: Suppressor of cytokine signaling 3

Curator: Steve Jupe
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SOS1
SOS1
Description: Son of sevenless homolog 1

Curator: Steve Jupe
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SOX2
SOX2
Description: Transcription factor SOX-2

Curator: Bruce May
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SPAG9
SPAG9
Description: C-Jun-amino-terminal kinase-interacting protein 4

Curator: Bruce May
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SRC1
SRC1
Description: Proto-oncogene tyrosine-protein kinase Src

Curator: Steve Jupe
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SREBP
SREBP
Description: Sterol regulatory element-binding protein 1

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SRGAP
SRGAP
Description: SLIT-ROBO Rho GTPase-activating protein 2

Curator: Steve Jupe
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STAT1
STAT1
Description: Signal transducer and activator of transcription 1

Curator: Steve Jupe
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STAT2
STAT2
Description: Signal transducer and activator of transcription 2

Curator: Steve Jupe
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STAT3
STAT3
Description: Signal transducer and activator of transcription 3

Curator: Steve Jupe
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STAT4
STAT4
Description: Signal transducer and activator of transcription 4

Curator: Steve Jupe
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STAT5
STAT5
Description: Signal transducer and activator of transcription 5

Curator: Steve Jupe
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STAT6
STAT6
Description: Signal transducer and activator of transcription 6

Curator: Steve Jupe
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STAT generic
STAT generic
Description: Signal transducer and activator of transcription family

Curator: Steve Jupe
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STING
STING
Description: Stimulator of interferon genes protein

Curator: Steve Jupe
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STXBP1
STXBP1
Description: {DESCRIPTION}

Curator: Steve Jupe
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SYK
SYK
Description: Tyrosine-protein kinase SYK

Curator: Steve Jupe
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TAK1
TAK1
Description: Mitogen-activated protein kinase kinase kinase 7

Curator: Steve Jupe
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TBXA2R
TBXA2R
Description: Thromboxane A2 receptor

Curator: Steve Jupe
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THROMBIN
THROMBIN
Description: Thrombin (factor 2a)

Curator: Steve Jupe
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TIRAP
TIRAP
Description: Toll/interleukin-1 receptor domain-containing adapter protein

Curator: Steve Jupe
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TNFR2
TNFR2
Description: Tumor necrosis factor receptor superfamily member 1B

Curator: Steve Jupe
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tPA
tPA
Description: Tissue-type plasminogen activator

Curator: Steve Jupe
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TRAF2
TRAF2
Description: TNF receptor-associated factor 2

Curator: Steve Jupe
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TRAF3
TRAF3
Description: TNF receptor-associated factor 3

Curator: Steve Jupe
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TRAF6
TRAF6
Description: TNF receptor-associated factor 6

Curator: Steve Jupe
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TRAM
TRAM
Description: Translocating chain-associated membrane protein 1

Curator: Steve Jupe
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TRIF
TRIF
Description: TIR domain-containing adapter molecule 2

Curator: Steve Jupe
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tropocollagen
tropocollagen
Description: Tropocollagen

Curator: Steve Jupe
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TXA2
TXA2
Description: Thromboxane A2 receptor

Curator: Steve Jupe
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TYK2
TYK2
Description: Non-receptor tyrosine-protein kinase TYK2

Curator: Steve Jupe
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UBA7
UBA7
Description: Ubiquitin-like modifier-activating enzyme 7

Curator: Steve Jupe
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UBCH8
UBCH8
Description: Ubiquitin/ISG15-conjugating enzyme E2 L6

Curator: Steve Jupe
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ubiquitin
ubiquitin
Description: Ubiquitin

Curator: Steve Jupe
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USP18
USP18
Description: Ubl carboxyl-terminal hydrolase 18

Curator: Steve Jupe
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viral protein
viral protein
Description: Viral protein

Curator: Steve Jupe
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viral protein dissolved
viral protein dissolved
Description: Viral protein, dissolved

Curator: Steve Jupe
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vWF
vWF
Description: von Willebrand factor

Curator: Steve Jupe
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ZAP70
ZAP70
Description: Tyrosine-protein kinase ZAP-70

Curator: Steve Jupe
Read more about EHLD

We would like to develop the EHLD library further as a community resource. If you use library elements, and design similar elements which are still missing, we would be very happy to incorporate them into the library, naming you as the author. Contact us at help@reactome.org.
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