Find Reactions, Proteins and Pathways

Pathway Browser

Visualize and interact with Reactome biological pathways

Analysis Tools

Merges pathway identifier mapping,
over-representation, and expression analysis

ReactomeFIViz

Designed to find pathways and network patterns related to cancer and other types of diseases

Documentation

Information to browse the database and use its principal tools for data analysis

Reactome Research Spotlight

[April 15, 2024] In the December issue of Toxicology and Applied Pharmacology, Zhang et al. (2023) used the R package, ReactomePA (Yu and He, 2016) to identify enriched pathways responding to nickel-induced transcriptional memory changes in response to a second respiratory toxicant, nicotine. Nicotine exposure upregulated a specific subset of genes in the cells previously exposed to nickel, identifying a robust activation of interferon (IFN) signaling, a driver of inflammation associated with many chronic lung diseases.

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Why Reactome

Reactome is a free, open-source, curated and peer-reviewed pathway database. Our goal is to provide intuitive bioinformatics tools for the visualization, interpretation and analysis of pathway knowledge to support basic research, genome analysis, modeling, systems biology and education. 

European Bioinformatics Institute (EMBL-EBI)
NYU Langone Health
Oregon Health & Science University
Ontario Institute for Cancer Research

The development of Reactome is supported by grants from the US National Institutes of Health (U24 HG012198) and the European Molecular Biology Laboratory.

Version 88 released on March 27th, 2024

2,698

Human Pathways

15,212

Reactions

11,442

Proteins

2,128

Small Molecules

1,047

Drugs

38,549

Literature References

What is Reactome?

Reactome is a curated database of pathways and reactions in human biology. Reactions can be considered as pathway ‘steps’. Reactome defines a ‘reaction’ as any event in biology that changes the state of a biological molecule. Binding, activation, translocation, degradation and classical biochemical events involving a catalyst are all reactions. Information in the database is authored by expert biologists, entered and maintained by Reactome’s team of Curators and Editorial staff. Reactome content frequently cross-references other resources e.g. NCBI, Ensembl, UniProt, KEGG (Gene and Compound), ChEBI, PubMed and GO. Inferred orthologous reactions Inferred orthologous reactions are available for 15 non-human species including mouse, rat, chicken, puffer fish, worm, fly, yeast, rice, and Arabidopsis

What is this guide For?

This guide introduces features of the Reactome website using a combination of short explanations and exercises. You will learn how to search, interpret the views, use the tools and if necessary find documentation or This email address is being protected from spambots. You need JavaScript enabled to view it. for help.

Online Tutorial

Available via the EBI Train Online system

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