Reactome: A Curated Pathway Database
Graph Database :: Data Schema
Entries: Regulation
Identifier Name
R-HSA-8944369 ''canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm]' positively regulates 'Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF'
R-HSA-5229351 ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-MMU-4793638 '14-3-3 epsilon dimer [cytosol]' negatively regulates 'HSF1 trimer translocates to the nucleus'
R-CEL-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-SSC-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-BTA-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-CFA-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-MMU-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-RNO-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-GGA-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-TGU-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-XTR-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-DRE-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-DME-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-ALL-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-BTA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-CFA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-MMU-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-RNO-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-GGA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-TGU-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-XTR-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-DRE-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-HSA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-CEL-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-HSA-8865694 '2x(p-STAT5A,p-STAT5B):BRWD1 gene [nucleoplasm]' negatively regulates 'BRWD1 gene expression is repressed by STAT5'
R-BTA-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-CFA-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-MMU-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-RNO-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-GGA-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-HSA-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-SSC-8951224 '2xIL12B [extracellular region]' negatively regulates 'Interleukin-12 binds Interleukin-12 receptor'
R-HSA-8951169 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression U2 small nuclear ribonucleoprotein A''
R-HSA-8951321 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of ADP-ribosylation factor 1'
R-HSA-8951191 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Glutathione S-transferase omega-1'
R-HSA-8951130 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Heterogeneous nuclear ribonucleoproteins A2/B1'
R-HSA-8951307 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Lamin-B1'
R-HSA-8951192 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Moesin'
R-HSA-8951189 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of PAK2'
R-HSA-8951273 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Phosphatidylinositol transfer protein alpha isoform'
R-HSA-8951114 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Plasminogen activator inhibitor 2'
R-HSA-8951301 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Ras-related protein Rap-1b'
R-HSA-8951132 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of Stress-70 protein, mitochondrial'
R-HSA-8951179 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of annexin A2'
R-HSA-8951113 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of capping actin protein of muscle Z-line alpha subunit 1'
R-HSA-8951127 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of cell division cycle 42'
R-HSA-8951216 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of heterogeneous nuclear ribonucleoprotein F'
R-HSA-8951299 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of lymphocyte cytosolic protein 1'
R-HSA-8951296 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of ribosomal protein lateral stalk subunit P0'
R-HSA-8951160 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of superoxide dismutase 2'
R-HSA-8951295 '2xp-Y693-STAT4 [nucleoplasm]' negatively regulates 'Expression of transaldolase 1'
R-HSA-8951165 '2xp-Y693-STAT4 [nucleoplasm]' positively regulates 'Expression of Aryl Hydrocarbon receptor-interacting protein'
R-HSA-8951256 '2xp-Y693-STAT4 [nucleoplasm]' positively regulates 'Expression of BolA-like protein 2'
R-HSA-8951286 '2xp-Y693-STAT4 [nucleoplasm]' positively regulates 'Expression of Carbonic anhydrase 1'