Reactome: A Curated Pathway Database
Graph Database :: Data Schema
Entries: Regulation
Identifier Name
R-HSA-8944369 ''canonical' WNT target genes:TCF/LEF:CTNNB1 [nucleoplasm]' positively regulates 'Transcription of canonical WNT targets is negatively regulated by NLK-dependent phosphorylation of TCF/LEF'
R-HSA-5229351 ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-MMU-4793638 '14-3-3 epsilon dimer [cytosol]' negatively regulates 'HSF1 trimer translocates to the nucleus'
R-BTA-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-MMU-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-GGA-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-SSC-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-XTR-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-RNO-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-DRE-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-ALL-8849358 '2-lysophosphatidylcholine [Golgi membrane]' positively regulates 'Dynein drives COPI-independent retrograde traffic from the Golgi to the ER'
R-MMU-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-RNO-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-BTA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-DRE-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-CFA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-GGA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-TGU-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-CEL-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-XTR-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-HSA-1474118 '2GCHFR:GCH1 [cytosol]' negatively regulates 'GCH1 reduces GTP to dihydroneopterin triphosphate'
R-HSA-71664 '3',5'-Cyclic AMP [cytosol]' negatively regulates 'phosphoenolpyruvate + ADP => pyruvate + ATP'
R-DRE-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-RNO-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-XTR-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-BTA-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-MMU-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-CFA-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-GGA-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-TGU-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-HSA-5692833 '3xUb, 2xp-S-NFKB1(1-968):p-S,T-MAP3K8:TNIP2 [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-HSA-451645 '3xUb-p-S927,S932-NFKB1(1-968) [cytosol]' negatively regulates 'NFKB p105, TPL2 (COT) and ABIN2 form a stable complex'
R-GGA-420923 '5-phospho-alpha-D-ribose 1-diphosphate [cytosol]' negatively regulates 'Formation of PPAT tetramers'
R-HSA-111290 '5-phospho-alpha-D-ribose 1-diphosphate [cytosol]' positively regulates 'Dissociation of phosphoribosyl pyrophosphate amidotransferase tetramer'
R-HSA-5096498 '5S RNA, 5.8S rRNA, 28S rRNA [nucleoplasm]' negatively regulates 'Formation of energy-dependent Nucleolar Silencing Complex (eNoSC)'
R-RNO-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-BTA-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-DRE-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-CFA-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-MMU-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-SSC-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-HSA-264772 'A2M tetramer [extracellular region]' negatively regulates 'BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1'
R-HSA-5422852 'ACADL tetramer [mitochondrial matrix]' is required for 'Linoleoyl-CoA is converted to cis,cis-3,6- dodecadienoyl-CoA by three cycles of beta-oxidation'
R-HSA-5422856 'ACADL tetramer [mitochondrial matrix]' is required for 'Trans,cis-lauro-2,6-dienoyl-CoA is converted to cis,cis-3,6- 4-cis-decenoyl-CoA by one cycle of beta-oxidation'
R-HSA-1449726 'ACTIV [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-CFA-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-SSC-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-TGU-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-XTR-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-DRE-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-RNO-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-GGA-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-BTA-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-MMU-1449726 'ACTIVIN [extracellular region]' positively regulates 'Follitropin is a heterodimer'
R-HSA-8849014 'ADIPOQ trimer:ADIPOR dimers [plasma membrane]' positively regulates 'Phosphorylation of ChREBP at Serine 568 by AMPK'