Reactome: A Curated Pathway Database
Graph Database :: Data Schema
Entries: NegativeGeneExpressionRegulation
Identifier Name
R-HSA-5229351 ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-HSA-8964503 'DREAM complex:CDC25A gene [nucleoplasm]' negatively regulates 'The CDC25A gene transcription is stimulated by MYC and E2F1 and inhibited by the DREAM complex'
R-HSA-8964507 'DREAM complex:CDC6 gene [nucleoplasm]' negatively regulates 'CDC6 gene expression is stimulated by E2F1 and repressed by the DREAM complex'
R-HSA-8964514 'DREAM complex:E2F1 gene [nucleoplasm]' negatively regulates 'E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2'
R-HSA-8964518 'DREAM complex:PCNA gene [nucleoplasm]' negatively regulates 'PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex'
R-HSA-8964523 'DREAM complex:RBL1 gene [nucleoplasm]' negatively regulates 'RBL1 gene expression is repressed by the DREAM complex'
R-HSA-8964532 'DREAM complex:TOP2A gene [nucleoplasm]' negatively regulates 'TOP2A gene gene expression is repressed by the DREAM complex'
R-HSA-6798356 'E2F7,E2F8 dimers:E2F1 Gene [nucleoplasm]' negatively regulates 'E2F7 and E2F8 homo- and heterodimers inhibit E2F1 expression'
R-HSA-6810147 'EGR2 [nucleoplasm]' negatively regulates 'HOXB1 gene is transcribed'
R-HSA-1253313 'ERBB4s80:TAB2:NCOR1:GFAP gene [nucleoplasm]' negatively regulates 'GFAP gene expression is inhibited by ERBB4:TAB2:NCOR1'
R-HSA-8954181 'ERBB4s80:TAB2:NCOR1:S100B gene [nucleoplasm]' negatively regulates 'S100B gene expression is inhibited by ERBB4:TAB2:NCOR1'
R-HSA-211284 'Forkhead box protein O1A [nucleoplasm]' negatively regulates 'FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein'
R-HSA-8964590 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CCNA2 gene [nucleoplasm]' negatively regulates 'CCNA2 gene expression is inhibited by RBL1 and RBL2'
R-HSA-8964594 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:CDK1 gene [nucleoplasm]' negatively regulates 'CDK1 gene expression is stimulated by E2F1 and repressed by RBL1 and RBL2'
R-HSA-8964548 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:E2F1 gene [nucleoplasm]' negatively regulates 'E2F1 gene transcription is inhibited by the DREAM complex, RBL1 and RBL2'
R-HSA-8978928 'HDAC1:RBL2:E2F4,E2F5:TFDP1,TFDP2; HDAC1:RBL1:E2F4:TFDP1,TFDP2:MYBL2 gene [nucleoplasm]' negatively regulates 'MYBL2 gene expression is inhibited by RBL1 and RBL2'
R-HSA-210847 'HES1 [nucleoplasm]' negatively regulates 'HNF6-dependent synthesis of NEUROG3 protein during morphogenesis'
R-HSA-6810143 'HOXB3 [nucleoplasm]' negatively regulates 'HOXB1 gene is transcribed'
R-MMU-8979005 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Ccna2 gene [nucleoplasm]' negatively regulates 'Ccna2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1'
R-MMU-8979018 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Cdk1 gene [nucleoplasm]' negatively regulates 'Cdk1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1'
R-MMU-8979011 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:E2f1 gene [nucleoplasm]' negatively regulates 'E2f1 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1'
R-MMU-8979000 'Hdac1:Rbl2:E2f4,E2f5:Tfdp1,Tfdp2; Hdac1:Rbl1:E2f4:Tfdp1,Tfdp2:Mybl2 gene [nucleoplasm]' negatively regulates 'Mybl2 gene expression is inhibited by Rbl1 or Rbl2 in complex with Hdac1'
R-HSA-8937836 'IL10 [extracellular region]' negatively regulates 'Expression of PTGS2'
R-HSA-6797295 'IL4, IL13 [extracellular region]' negatively regulates 'Expression of IL18, ALOX5'
R-HSA-6797298 'IL4, IL13 [extracellular region]' negatively regulates 'Expression of PTGS2'
R-HSA-994052 'IRF2:promoters of INF alpha, INF beta [nucleoplasm]' negatively regulates 'Expression of Interferon-alpha and beta'
R-HSA-517803 'KSRP:mRNA Degradation Complex [cytosol]' negatively regulates 'Expression of IL-8'
R-HSA-5660538 'MTF1 dimer:12Zn2+:HMGCR gene [nucleoplasm]' negatively regulates 'Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)'
R-HSA-5340415 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]' negatively regulates 'Expression of CYP7A1'
R-HSA-976211 'NF-kB complex [nucleoplasm]' negatively regulates 'Expression of PPARG'
R-HSA-8869557 'NPM1:TFAP2A homodimer:HSPD1 gene [nucleoplasm]' negatively regulates 'HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer '
R-HSA-8869562 'NPM1:TFAP2A homodimer:MYBL2 gene [nucleoplasm]' negatively regulates 'The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer'
R-HSA-8869563 'NPM1:TFAP2A homodimer:NOP2 gene [nucleoplasm]' negatively regulates 'The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer'
R-HSA-421342 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' negatively regulates 'Expression of BMAL1 (ARNTL).'
R-HSA-1368175 'NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm]' negatively regulates 'Expression of CLOCK'
R-HSA-1368161 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]' negatively regulates 'Expression of NPAS2'
R-HSA-1480006 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]' negatively regulates 'Expression of NR1D1 (REV-ERBA)'
R-HSA-1368172 'NR1D1:heme:Corepressors:PPARGC1A gene [nucleoplasm]' negatively regulates 'Expression of PPARGC1A (PGC-1alpha)'
R-HSA-976231 'NR2F2 [nucleoplasm]' negatively regulates 'Expression of PPARG'
R-HSA-5159208 'NR6A1(GCNF):TDGF1 gene [nucleoplasm]' negatively regulates 'Expression of TDGF1 (CRIPTO)'
R-HSA-1183067 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' negatively regulates 'Expression of Leptin'
R-HSA-6804227 'PRDM1:TP53 Gene [nucleoplasm]' negatively regulates 'PRDM1 represses TP53 expression'
R-HSA-8956239 'PUM2:DCUN1D3 mRNA [cytosol]' negatively regulates 'Translation of DCUN1D3 is inhibited by PUM2'
R-HSA-8951925 'RUNX3:CBFB:RUNX1 gene [nucleoplasm]' negatively regulates 'RUNX1 gene expression is inhibited by RUNX3'
R-HSA-8878211 'RUNX3:JAG1 gene [nucleoplasm]' negatively regulates 'JAG1 gene expression is inhibited by RUNX3'
R-HSA-8878245 'RUNX3:NOTCH1 coactivator complex:HES1 gene [nucleoplasm]' negatively regulates 'HES1 gene transcription is inhibited by RUNX3'
R-HSA-5159229 'SALL4:SALL1 gene [nucleoplasm]' negatively regulates 'Expression of SALL1'
R-HSA-5159192 'SALL4:SALL4 gene [nucleoplasm]' negatively regulates 'Expression of SALL4'
R-HSA-5656522 'SIK1 [nucleoplasm]' negatively regulates 'Expression of PERIOD-1'
R-HSA-3009212 'SMAD7 [nucleoplasm]' negatively regulates 'WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it'
R-HSA-5666047 'SRF:MKL1:SCAI [nucleoplasm]' negatively regulates 'SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it'
R-HSA-5339676 'TCF7L2/TCF7L1:CTBPs [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-HSA-8864939 'TFAP2A homodimer:VEGFA Gene [nucleoplasm]' negatively regulates 'VEGFA gene expression is inhibited by the TFAP2A homodimer'
R-HSA-8865279 'TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm]' negatively regulates 'CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C'
R-HSA-976237 'TGF-beta 1 [extracellular region]' negatively regulates 'Expression of CEBPA'