Reactome: A Curated Pathway Database
Graph Database :: Data Schema
Entries: NegativeGeneExpressionRegulation
Identifier Name
R-HSA-5229351 ''canonical' WNT target genes:TCF/LEF:TLE tetramer:HDAC1 [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-HSA-6810147 'EGR2 [nucleoplasm]' negatively regulates 'HOXB1 gene is transcribed'
R-HSA-211284 'Forkhead box protein O1A [nucleoplasm]' negatively regulates 'FOXOA2-, MAFA-, and PAX6-dependent synthesis of PDX1 protein'
R-HSA-210847 'HES1 [nucleoplasm]' negatively regulates 'HNF6-dependent synthesis of NEUROG3 protein during morphogenesis'
R-HSA-6810143 'HOXB3 [nucleoplasm]' negatively regulates 'HOXB1 gene is transcribed'
R-HSA-8937836 'IL10 [extracellular region]' negatively regulates 'Expression of PTGS2'
R-HSA-6797295 'IL4, IL13 [extracellular region]' negatively regulates 'Expression of IL18, ALOX5'
R-HSA-6797298 'IL4, IL13 [extracellular region]' negatively regulates 'Expression of PTGS2'
R-HSA-994052 'IRF2:promoters of INF alpha, INF beta [nucleoplasm]' negatively regulates 'Expression of Interferon-alpha and beta'
R-HSA-517803 'KSRP:mRNA Degradation Complex [cytosol]' negatively regulates 'Expression of IL-8'
R-HSA-5660538 'MTF1 dimer:12Zn2+:HMGCR gene [nucleoplasm]' negatively regulates 'Expression of 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase (HMGCR)'
R-HSA-5340415 'NCOA1,2:RXRA:NR1H4:DCA,CDCA,LCHA [nucleoplasm]' negatively regulates 'Expression of CYP7A1'
R-HSA-976211 'NF-kB complex [nucleoplasm]' negatively regulates 'Expression of PPARG'
R-HSA-8869557 'NPM1:TFAP2A homodimer:HSPD1 gene [nucleoplasm]' negatively regulates 'HSPD1 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer '
R-HSA-8869562 'NPM1:TFAP2A homodimer:MYBL2 gene [nucleoplasm]' negatively regulates 'The MYBL2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer'
R-HSA-8869563 'NPM1:TFAP2A homodimer:NOP2 gene [nucleoplasm]' negatively regulates 'The NOP2 gene expression is repressed by the complex of NPM1 and TFAP2A homodimer'
R-HSA-421342 'NR1D1:heme:Corepressors:ARNTL gene [nucleoplasm]' negatively regulates 'Expression of BMAL1 (ARNTL).'
R-HSA-1368175 'NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm]' negatively regulates 'Expression of CLOCK'
R-HSA-1368161 'NR1D1:heme:Corepressors:NPAS2 gene [nucleoplasm]' negatively regulates 'Expression of NPAS2'
R-HSA-1480006 'NR1D1:heme:Corepressors:NR1D1 gene [nucleoplasm]' negatively regulates 'Expression of NR1D1 (REV-ERBA)'
R-HSA-1368172 'NR1D1:heme:Corepressors:PPARGC1A gene [nucleoplasm]' negatively regulates 'Expression of PPARGC1A (PGC-1alpha)'
R-HSA-976231 'NR2F2 [nucleoplasm]' negatively regulates 'Expression of PPARG'
R-HSA-5159208 'NR6A1(GCNF):TDGF1 gene [nucleoplasm]' negatively regulates 'Expression of TDGF1 (CRIPTO)'
R-HSA-1183067 'PPARG:Fatty Acid:RXRA:Mediator:Coactivator Complex [nucleoplasm]' negatively regulates 'Expression of Leptin'
R-HSA-6804227 'PRDM1:TP53 Gene [nucleoplasm]' negatively regulates 'PRDM1 represses TP53 expression'
R-HSA-5159229 'SALL4:SALL1 gene [nucleoplasm]' negatively regulates 'Expression of SALL1'
R-HSA-5159192 'SALL4:SALL4 gene [nucleoplasm]' negatively regulates 'Expression of SALL4'
R-HSA-5656522 'SIK1 [nucleoplasm]' negatively regulates 'Expression of PERIOD-1'
R-HSA-3009212 'SMAD7 [nucleoplasm]' negatively regulates 'WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it'
R-HSA-5666047 'SRF:MKL1:SCAI [nucleoplasm]' negatively regulates 'SRF:MKL1 stimulate ITGB1 expression while SCAI inhibits it'
R-HSA-5339676 'TCF7L2/TCF7L1:CTBPs [nucleoplasm]' negatively regulates 'Transcription of canonical WNT targets is repressed by the TLE:HDAC and TCF/CTBP complexes'
R-HSA-8864939 'TFAP2A homodimer:VEGFA Gene [nucleoplasm]' negatively regulates 'VEGFA gene expression is inhibited by the TFAP2A homodimer'
R-HSA-8865279 'TFAP2C homodimer:MYC:KDM5B:CDKN1A gene [nucleoplasm]' negatively regulates 'CDKN1A gene expression is stimulated by TFAP2A and repressed by TFAP2C'
R-HSA-976237 'TGF-beta 1 [extracellular region]' negatively regulates 'Expression of CEBPA'
R-HSA-976214 'TGF-beta 1 [extracellular region]' negatively regulates 'Expression of PPARG'
R-HSA-976204 'TNF-alpha [extracellular region]' negatively regulates 'Expression of CEBPA'
R-HSA-976198 'Wnt-1 or Wnt-10b [extracellular region]' negatively regulates 'Expression of CEBPA'
R-HSA-2186613 'p-2S-SMAD2/3:SMAD4:TGIF:HDAC1 [nucleoplasm]' negatively regulates 'WWTR1:SMAD stimulates transcription of SERPINE1 while TGIF:SMAD and SMAD7 inhibit it'
R-HSA-1484103 'p-SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 [nucleoplasm]' negatively regulates 'MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex'
R-HSA-8865694 'p-STAT5 dimer:BRWD1 gene [nucleoplasm]' negatively regulates 'BRWD1 gene expression is repressed by STAT5'
R-HSA-6797256 'p-Y705-STAT3 dimer [nucleoplasm]' negatively regulates 'Expression of FASLG'
R-HSA-6797257 'p-Y705-STAT3 dimer [nucleoplasm]' negatively regulates 'Expression of NDN,TP53'
R-HSA-8937237 AHRR:ARNT [nucleoplasm] Expression of CYP1A1
R-HSA-8931939 CILP1 negatively regulates ligand-induced IGF1R autophosphorylation
R-HSA-8878902 CREM:PER1 gene [nucleoplasm] Expression of PERIOD-1
R-HSA-6798356 E2F7 inhibits E2F1 expression E2F7:E2F1 Gene [nucleoplasm]
R-HSA-3209181 ERF inhibits ETS2 expression ERF:ETS2 Gene [nucleoplasm]
R-HSA-5617417 Expression of GLI1 is repressed by GLI3R in the absence of Hh signaling GLI1 gene:GLI3R [nucleoplasm]
R-HSA-5617418 Expression of GLI2 is repressed by GLI3R in the absence of Hh signaling GLI2 gene:GLI3R [nucleoplasm]
R-HSA-8878906 Expression of PERIOD-2 NFIL3:BHLHE41:PER2 gene [nucleoplasm]
R-HSA-5612509 Expression of PTCH1 is repressed by GLI3R in the absence of Hh signaling PTCH1 gene:GLI3R [nucleoplasm]
R-MMU-8931939 Homologues of glc-fuc-CILP [extracellular region] IGF1,2:IGF1R autophosphorylates
R-HSA-6785079 IL10 [extracellular region] IL10 negatively regulates extracellular inflammatory mediators
R-HSA-8937837 IL10 [extracellular region] IL10 negatively regulates plasma membrane-associated inflammatory mediators
R-RNO-994052 IRF2:promoters of INF alpha, INF beta [nucleoplasm] Expression of Interferon-alpha and beta