Reactome: A Curated Pathway Database
Graph Database :: Data Schema
Entries: FailedReaction
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Identifier Name
R-HSA-5246696 APC truncation mutants are not K63 polyubiquitinated
R-HSA-4791278 APC truncation mutants have impaired AXIN binding
R-HSA-4839734 AXIN mutants destabilize the destruction complex
R-HSA-3656523 An anchoring protein ZFYVE9 (SARA) does not recruit SMAD2/3 to TGFB1:TGFBR2:p-TGFBR1 KD Mutants
R-HSA-5688025 CCDC59:TTF1:SFTPB mutant gene does not produce pro-SFTPB protein
R-HSA-4839634 CTNNB1 S33 mutants aren't phosphorylated by GSK3beta
R-HSA-4839635 CTNNB1 S37 mutants aren't phosphorylated by GSK3beta
R-HSA-4827388 CTNNB1 S45 mutants aren't phosphorylated by CK1alpha
R-HSA-4839638 CTNNB1 T41 mutants aren't phosphorylated by GSK3beta
R-HSA-5682111 Defective ABCA1 does not transport CHOL from transport vesicle membrane to plasma membrane
R-HSA-5682311 Defective ABCA12 does not transport lipids from cytosol to extracellular region
R-HSA-5688397 Defective ABCA3 does not transport PC, PG from ER membrane to lamellar body
R-HSA-5683672 Defective ABCA3 does not transport SFTPs, CHOL from lamellar body to extracellular region
R-HSA-2466802 Defective ABCA4 does not transport NRPE from disc membranes
R-HSA-5678517 Defective ABCB11 does not transport bile salts from cytosol to extracellular region
R-HSA-5678749 Defective ABCB4 does not transport PC from plasma membrane to extracellular region
R-HSA-5683355 Defective ABCB6 does not transport porphyrin from cytosol into mitochondria matrix
R-HSA-5679031 Defective ABCC2 does not transport BMG,BDG from cytosol to extracellular region
R-HSA-5690340 Defective ABCC6 does not transport organic anion from cytosol to extracellular region
R-HSA-5683113 Defective ABCC8 does not form functional KATP channels, causing hyperinsulinemic hypoglycemia
R-HSA-5678418 Defective ABCC9 (in KCNJ11:ABCC9) does not transport K+ from extracellular region to cytosol
R-HSA-5684043 Defective ABCD1 does not transfer LCFAs from cytosol to peroxisomal matrix
R-HSA-5683325 Defective ABCD4 does not transport Cbl from lysosomal lumen to cytosol
R-HSA-5679145 Defective ABCG5 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region
R-HSA-5679101 Defective ABCG8 (in ABCG5:ABCG8) does not transport sterols from cytosol to extracellular region
R-HSA-5603251 Defective ACTH does not bind MCR2
R-HSA-5579081 Defective ACY1 does not hydrolyse mercapturic acids
R-HSA-5579084 Defective AHCY does not hydrolyse AdoHcy
R-HSA-5656438 Defective ALDOB does not cleave Fru 1-P to GA and DHAP
R-HSA-4549382 Defective ALG1 does not transfer the first Man to the N-glycan precursor
R-HSA-4551297 Defective ALG11 does not transfer Man to the N-glycan precursor
R-HSA-4720497 Defective ALG12 does not add mannose to the N-glycan precursor
R-HSA-5633241 Defective ALG14 does not transfer GlcNAc from UDP-GlcNAc to GlcNAcDOLP
R-HSA-4549368 Defective ALG2 does not transfer a second Man to N-glycan precursor
R-HSA-4720473 Defective ALG3 does not add mannose to the N-glycan precursor
R-HSA-4724291 Defective ALG6 does not add glucose to the N-glycan precursor
R-HSA-4724330 Defective ALG8 does not add glucose to the N-glycan precursor
R-HSA-4720478 Defective ALG9 does not add mannose to the N-glycan precursor
R-HSA-3296477 Defective AMN does not transport GIF:Cbl
R-HSA-2282889 Defective ARSB does not hydrolyse sulfate from GalNAc4S
R-HSA-5621425 Defective AVP does not bind AVPRs
R-HSA-4420365 Defective B3GALT6 does not transfer Gal to the tetrasaccharide linker
R-HSA-6785565 Defective B3GALTL does not transfer glucose to O-fucosyl-proteins
R-HSA-3560802 Defective B3GAT3 does not transfer GlcA to tetrasaccharide linker
R-HSA-4793956 Defective B4GALT1 does not add Gal to N-glycan
R-HSA-3656230 Defective B4GALT1 does not transfer Gal to keratan substrates
R-HSA-3560804 Defective B4GALT7 does not transfer Gal to xylosyl-unit of the tetrasaccharide linker
R-HSA-6785524 Defective C1GALT1C1 does not bind C1GALT1
R-HSA-3325546 Defective CD320 does not transport extracellular TCII:Cbl to endosome
R-HSA-5678822 Defective CFTR does not transport Cl- from cytosol to extracellular region
R-HSA-3636919 Defective CHST14 does not transfer SO4(2-) to GalNAc in dermatan or DS
R-HSA-3595175 Defective CHST3 does not transfer SO4(2-) to chondroitin
R-HSA-3656269 Defective CHST6 does not transfer SO4(2-) to GlcNAc residues on keratan-PG
R-HSA-3595176 Defective CHSY1 does not transfer GalNAc to chondroitin
R-HSA-3595178 Defective CHSY1 does not transfer GlcA to chondroitin