Reactome | SCF-FBXL7 ubiquitinates AURKA

Schema > Reaction > Entries

SCF-FBXL7 ubiquitinates AURKA Show undefined attributes

catalystActivity	[CatalystActivity:10545062] ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
dbId	10545064
displayName	SCF-FBXL7 ubiquitinates AURKA
eventOf	[Pathway:R-XTR-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis - Xenopus tropicalis
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:422949] negative regulation of G2/M transition of mitotic cell cycle
inferredFrom	[Reaction:R-HSA-8854041] SCF-FBXL7 ubiquitinates AURKA - Homo sapiens
input	[Complex:R-XTR-8854031] SCF-FBXL7:AURKA [cytosol] 3 × [DefinedSet:R-XTR-113595] Ub [cytosol]
isInDisease	false
isInferred	true
name	SCF-FBXL7 ubiquitinates AURKA
output	[Complex:R-XTR-8854038] SCF-FBXL7:PolyUb-AURKA [cytosol]
precedingEvent	[Reaction:R-XTR-8853496] SCF:FBXL7 binds AURKA - Xenopus tropicalis
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8854041
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8854050] FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
(inferredTo)	[Reaction:R-HSA-8854041] SCF-FBXL7 ubiquitinates AURKA