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Schema
>
Reaction
>
Entries
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
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catalystActivity
[CatalystActivity:109324] 5'-nucleotidase activity of NT5C2 tetramer [cytosol]
catalystActivityReference
[CatalystActivityReference:9643271] 5'-nucleotidase activity of NT5C2 tetramer [cytosol] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
category
transition
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:74183] Jassal, B, 2003-07-17 08:31:43
crossReference
[DatabaseIdentifier:11880697] Rhea:29380
dbId
74248
displayName
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
eventOf
[Pathway:R-HSA-74259] Purine catabolism - Homo sapiens
followingEvent
[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose - Homo sapiens
input
[DefinedSet:R-ALL-500120] (d)GMP, (d)IMP [cytosol]
[SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:109314] High Km soluble 5'-nucleotidase from human placenta
[LiteratureReference:500117] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
[LiteratureReference:109348] Cytosolic high Km 5'-nucleotidase and 5'(3')-deoxyribonucleotidase in substrate cycles involved in nucleotide metabolism
[LiteratureReference:109319] Distinct roles for recombinant cytosolic 5'-nucleotidase I and -II in AMP and IMP catabolism in COS-7 and H9c2 rat myoblast cell lines
[LiteratureReference:109306] Mammalian 5'-nucleotidases
modified
[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name
(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)
orthologousEvent
[Reaction:R-GGA-421179] inosine 5'-monophosphate (IMP) + H2O => inosine + orthophosphate - Gallus gallus
[Reaction:R-DDI-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Dictyostelium discoideum
[Reaction:R-CEL-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Caenorhabditis elegans
[Reaction:R-DME-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Drosophila melanogaster
[Reaction:R-GGA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Gallus gallus
[Reaction:R-XTR-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Xenopus tropicalis
[Reaction:R-SSC-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Sus scrofa
[Reaction:R-BTA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Bos taurus
[Reaction:R-CFA-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Canis familiaris
[Reaction:R-RNO-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Rattus norvegicus
[Reaction:R-MMU-74248] (d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2) - Mus musculus
output
[DefinedSet:R-ALL-500118] Gu-Rib, dG, Ino, dI [cytosol]
[SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent
[Reaction:R-HSA-73797] FAICAR => IMP + H2O - Homo sapiens
[Reaction:R-HSA-74215] HPRT1 catalyzes the conversion of guanine or hypoxanthine to GMP or IMP - Homo sapiens
[Reaction:R-HSA-76590] AMP + H2O => IMP + NH4+ (AMPD) - Homo sapiens
[Reaction:R-HSA-73792] XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate - Homo sapiens
releaseDate
2004-07-06
reviewStatus
[ReviewStatus:9821382] five stars
revised
[InstanceEdit:504064] D'Eustachio, P, 2010-02-05
schemaClass
Reaction
species
[Species:48887] Homo sapiens
stId
R-HSA-74248
summation
[Summation:178300] Cytosolic purine 5'-nucleotidase (NT5C2) catalyzes the hydro...
Referrals
(hasEvent)
[Pathway:R-HSA-74259] Purine catabolism
(precedingEvent)
[Reaction:R-HSA-74249] PNP catalyzes the conversion of (deoxy)guanosine to guanine and (deoxy)ribose
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