Reactome | MDH2 dimer dehydrogenates MAL

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MDH2 dimer dehydrogenates MAL Show undefined attributes

catalystActivity	[CatalystActivity:70978] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9643763] L-malate dehydrogenase activity of MDH2 dimer [mitochondrial matrix] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates
category	transition
compartment	[Compartment:5460] mitochondrial matrix
crossReference	[DatabaseIdentifier:9854228] RHEA:21433 [DatabaseIdentifier:11880700] Rhea:21433
dbId	70979
displayName	MDH2 dimer dehydrogenates MAL
edited	[InstanceEdit:9859599] Stephan, Ralf, 2024-01-22
eventOf	[Pathway:R-HSA-9856872] Malate-aspartate shuttle - Homo sapiens [Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) - Homo sapiens
followingEvent	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 - Homo sapiens [Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR - Homo sapiens [Reaction:R-HSA-70975] CS acetylates OA to citrate - Homo sapiens [Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu - Homo sapiens
input	[SimpleEntity:R-ALL-113544] MAL [mitochondrial matrix] [SimpleEntity:R-ALL-113526] NAD+ [mitochondrial matrix]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451039] An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates [LiteratureReference:198468] Aggregation states of mitochondrial malate dehydrogenase [LiteratureReference:9854231] Structural Comparison of hMDH2 Complexed with Natural Substrates and Cofactors: The Importance of Phosphate Binding for Active Conformation and Catalysis [LiteratureReference:9854217] Malate dehydrogenase 2 deficiency is an emerging cause of pediatric epileptic encephalopathy with a recognizable biochemical signature [LiteratureReference:9854243] Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	MDH2 dimer dehydrogenates MAL (S)-malate + NAD(+) => H(+) + NADH + oxaloacetate
orthologousEvent	[Reaction:R-GGA-373047] malate + NAD+ <=> oxaloacetate + NADH + H+ - Gallus gallus [Reaction:R-MMU-70979] MDH2 dimer dehydrogenates MAL - Mus musculus [Reaction:R-PFA-70979] MDH2 dimer dehydrogenates MAL - Plasmodium falciparum [Reaction:R-CFA-70979] MDH2 dimer dehydrogenates MAL - Canis familiaris [Reaction:R-BTA-70979] MDH2 dimer dehydrogenates MAL - Bos taurus [Reaction:R-SSC-70979] MDH2 dimer dehydrogenates MAL - Sus scrofa [Reaction:R-SPO-70979] MDH2 dimer dehydrogenates MAL - Schizosaccharomyces pombe [Reaction:R-DRE-70979] MDH2 dimer dehydrogenates MAL - Danio rerio [Reaction:R-DME-70979] MDH2 dimer dehydrogenates MAL - Drosophila melanogaster [Reaction:R-SCE-70979] MDH2 dimer dehydrogenates MAL - Saccharomyces cerevisiae [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL - Caenorhabditis elegans [Reaction:R-GGA-70979] MDH2 dimer dehydrogenates MAL - Gallus gallus [Reaction:R-XTR-70979] MDH2 dimer dehydrogenates MAL - Xenopus tropicalis [Reaction:R-RNO-70979] MDH2 dimer dehydrogenates MAL - Rattus norvegicus
output	[SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix] [SimpleEntity:R-ALL-29362] NADH [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-70982] FH tetramer hydrates fumarate to L-malate - Homo sapiens [Reaction:R-HSA-376851] SLC25A11 exchanges 2-OG and MAL - Homo sapiens
releaseDate	2004-07-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9861215] Hill, David P, 2024-02-15
revised	[InstanceEdit:451045] D'Eustachio, P, 2009-12-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-70979
summation	[Summation:71413] Mitochondrial malate dehydrogenase (MDH2) dimer catalyzes th...

Referrals

(hasEvent)	[Pathway:R-HSA-71403] Citric acid cycle (TCA cycle) [Pathway:R-HSA-9856872] Malate-aspartate shuttle
(precedingEvent)	[Reaction:R-HSA-163217] Complex I oxidises NADH to NAD+, reduces CoQ to QH2 [Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu [Reaction:R-HSA-9012016] FAHD1 dimer hydrolyses OA to PYR [Reaction:R-HSA-70975] CS acetylates OA to citrate

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