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Schema
>
BlackBoxEvent
>
Entries
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
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authored
[InstanceEdit:6791012] May, Bruce, 2015-08-16
catalystActivity
[CatalystActivity:6791528] endoribonuclease activity of NOB1 [cytosol]
catalystActivityReference
[CatalystActivityReference:9643798] endoribonuclease activity of NOB1 [cytosol] Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing
category
omitted
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId
6791223
displayName
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
edited
[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf
[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Homo sapiens
input
[Complex:R-HSA-6791531] 18SE pre-40S particle [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-6791522] RIOK3 [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:6791579] Analysis of two human pre-ribosomal factors, bystin and hTsr1, highlights differences in evolution of ribosome biogenesis between yeast and mammals
[LiteratureReference:6791557] Distinct cytoplasmic maturation steps of 40S ribosomal subunit precursors require hRio2
[LiteratureReference:6791576] The kinase activity of human Rio1 is required for final steps of cytoplasmic maturation of 40S subunits
[LiteratureReference:6791523] Gradual processing of the ITS1 from the nucleolus to the cytoplasm during synthesis of the human 18S rRNA
[LiteratureReference:6797209] Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells
[LiteratureReference:6790972] WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA
[LiteratureReference:6797220] CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation
[LiteratureReference:6797241] RNA helicase Prp43 and its co-factor Pfa1 promote 20 to 18 S rRNA processing catalyzed by the endonuclease Nob1
[LiteratureReference:6790848] Tandem affinity purification combined with inducible shRNA expression as a tool to study the maturation of macromolecular assemblies
modified
[InstanceEdit:10203599] Wright, Adam, 2024-03-07
name
18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol
orthologousEvent
[BlackBoxEvent:R-BTA-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Bos taurus
[BlackBoxEvent:R-RNO-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Rattus norvegicus
[BlackBoxEvent:R-MMU-6791223] 18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol - Mus musculus
output
[Complex:R-HSA-72392] 40S ribosomal complex [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791518] BYSL [cytosol]
[EntityWithAccessionedSequence:R-HSA-380315] CSNK1D [cytosol]
[EntityWithAccessionedSequence:R-HSA-205877] CSNK1E [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791520] LTV1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791524] NOB1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791509] PNO1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791525] RIOK1 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791533] RIOK2 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791522] RIOK3 [cytosol]
[EntityWithAccessionedSequence:R-HSA-6791570] TSR1 [cytosol]
precedingEvent
[BlackBoxEvent:R-HSA-6791222] 21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA - Homo sapiens
regulatedBy
[Requirement:R-HSA-8949027] Requirement by 'WBSCR22 [nucleoplasm]'
[Requirement:R-HSA-9023927] Requirement by 'CSNK1E [cytosol]'
[Requirement:R-HSA-9023929] Requirement by 'CSNK1D [cytosol]'
regulationReference
[RegulationReference:9641544] Requirement by 'CSNK1E [cytosol]' CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation
[RegulationReference:9642617] Requirement by 'CSNK1D [cytosol]' CK1? and CK1? are components of human 40S subunit precursors required for cytoplasmic 40S maturation
[RegulationReference:9642785] Requirement by 'WBSCR22 [nucleoplasm]' WBSCR22/Merm1 is required for late nuclear pre-ribosomal RNA processing and mediates N7-methylation of G1639 in human 18S rRNA
releaseDate
2016-03-23
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-6791223
summation
[Summation:6791530] Exonuclease activity of the exosome (Preti et al. 2013) and ...
Referrals
(hasEvent)
[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol
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