Reactome | 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA

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32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA Show undefined attributes

authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId	6791219
displayName	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Homo sapiens
input	[Complex:R-HSA-6791562] 32S pre-rRNA:Rix1:LAS1L:NOL9:SENP3 [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6791144] Interdependence of Pes1, Bop1, and WDR12 controls nucleolar localization and assembly of the PeBoW complex required for maturation of the 60S ribosomal subunit [LiteratureReference:6791150] Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex [LiteratureReference:6791154] The BRCT domain of mammalian Pes1 is crucial for nucleolar localization and rRNA processing [LiteratureReference:6791153] Mammalian WDR12 is a novel member of the Pes1-Bop1 complex and is required for ribosome biogenesis and cell proliferation [LiteratureReference:6791167] Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing [LiteratureReference:6791558] LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis [LiteratureReference:8869319] Critical role of nucleostemin in pre-rRNA processing
modified	[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name	32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA
orthologousEvent	[BlackBoxEvent:R-SCE-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Saccharomyces cerevisiae [BlackBoxEvent:R-SPO-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Schizosaccharomyces pombe [BlackBoxEvent:R-DDI-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Dictyostelium discoideum [BlackBoxEvent:R-CEL-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Caenorhabditis elegans [BlackBoxEvent:R-DME-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Drosophila melanogaster [BlackBoxEvent:R-XTR-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Xenopus tropicalis [BlackBoxEvent:R-SSC-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Sus scrofa [BlackBoxEvent:R-BTA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Bos taurus [BlackBoxEvent:R-CFA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Canis familiaris [BlackBoxEvent:R-RNO-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Rattus norvegicus [BlackBoxEvent:R-MMU-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Mus musculus
output	[Complex:R-HSA-6791568] 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-6791228] 45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA - Homo sapiens
regulatedBy	[Requirement:R-HSA-8948996] Requirement by 'GNL3:EBNA1BP2:DDX21:PES1 [nucleoplasm]' [Requirement:R-HSA-8949019] Requirement by 'PeBoW complex [nucleoplasm]' [Requirement:R-HSA-8949024] Requirement by 'LAS1L [nucleoplasm]' [Requirement:R-HSA-8949030] Requirement by 'NOL9 [nucleoplasm]'
regulationReference	[RegulationReference:9641311] Requirement by 'LAS1L [nucleoplasm]' LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis [RegulationReference:9641419] Requirement by 'GNL3:EBNA1BP2:DDX21:PES1 [nucleoplasm]' Critical role of nucleostemin in pre-rRNA processing [RegulationReference:9642630] Requirement by 'PeBoW complex [nucleoplasm]' Dominant-negative Pes1 mutants inhibit ribosomal RNA processing and cell proliferation via incorporation into the PeBoW-complex [RegulationReference:9642928] Requirement by 'NOL9 [nucleoplasm]' LAS1L interacts with the mammalian Rix1 complex to regulate ribosome biogenesis
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6791219
summation	[Summation:6797221] Unknown nucleases process the 32S precursor rRNA (pre-rRNA) ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
(hasEvent)	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol

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