Reactome | 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA

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12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA Show undefined attributes

authored	[InstanceEdit:6791012] May, Bruce, 2015-08-16
category	omitted
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:6791220] May, Bruce, 2015-08-19
dbId	6791218
displayName	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
edited	[InstanceEdit:6791012] May, Bruce, 2015-08-16
eventOf	[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol - Homo sapiens
input	[Complex:R-HSA-6791568] 28S rRNA:12S pre-rRNA:Rix1:LAS1L:NOL9:SENP3:PeBoW [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:6791506] C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [LiteratureReference:6791534] The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L [LiteratureReference:6799479] ISG20L2, a novel vertebrate nucleolar exoribonuclease involved in ribosome biogenesis [LiteratureReference:8878865] Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing
modified	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
name	12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA
orthologousEvent	[BlackBoxEvent:R-XTR-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Xenopus tropicalis [BlackBoxEvent:R-SSC-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Sus scrofa [BlackBoxEvent:R-BTA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Bos taurus [BlackBoxEvent:R-CFA-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Canis familiaris [BlackBoxEvent:R-RNO-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Rattus norvegicus [BlackBoxEvent:R-MMU-6791218] 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA - Mus musculus
output	[Complex:R-HSA-72499] 60S ribosomal complex [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-6791219] 32S pre-rRNA is nucleolytically processed at site 4 (4a) to yield 12S pre-rRNA and 28S rRNA - Homo sapiens
regulatedBy	[Requirement:R-HSA-8949002] Requirement by 'C1D [nucleoplasm]' [Requirement:R-HSA-8949010] Requirement by 'SKIV2L2 [nucleoplasm]' [Requirement:R-HSA-8949014] Requirement by 'DIS3 [nucleoplasm]' [Requirement:R-HSA-8949034] Requirement by 'MPHOSPH6 [nucleoplasm]' [Requirement:R-HSA-8949040] Requirement by 'EXOSC10 [nucleoplasm]' [Requirement:9676147] Requirement by 'ERI1 [nucleoplasm]' [Requirement:9676148] Requirement by 'ISG20L2 [nucleoplasm]'
regulationReference	[RegulationReference:9641313] Requirement by 'MPHOSPH6 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641467] Requirement by 'EXOSC10 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641573] Requirement by 'DIS3 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9641616] Requirement by 'C1D [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing [RegulationReference:9642638] Requirement by 'SKIV2L2 [nucleoplasm]' C1D and hMtr4p associate with the human exosome subunit PM/Scl-100 and are involved in pre-rRNA processing
releaseDate	2016-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8855036] Vincent, Nicholas G, 2016-01-30
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-6791218
summation	[Summation:6798644] The 12S pre-rRNA is nucleolytically cleaved to yield 5.8S rR...

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(hasEvent)

[Pathway:R-HSA-6791226] Major pathway of rRNA processing in the nucleolus and cytosol

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