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Entries
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
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authored
[InstanceEdit:5628889] Orlic-Milacic, Marija, 2014-10-24
[InstanceEdit:5668821] Rivero Crespo, Francisco, 2014-12-26
compartment
[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created
[InstanceEdit:5625885] Orlic-Milacic, Marija, 2014-10-08
dbId
5625886
displayName
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
edited
[InstanceEdit:5671747] Orlic-Milacic, Marija, 2015-02-02
eventOf
[Pathway:R-HSA-5625740] RHO GTPases activate PKNs - Homo sapiens
goBiologicalProcess
[GO_BiologicalProcess:436782] regulation of androgen receptor signaling pathway
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-5625717] Phosphorylated PKN1 binds androgen receptor (AR) - Homo sapiens
[Reaction:R-HSA-5625738] p-T774-PKN1:AR:Androgen complex translocates to the nucleus - Homo sapiens
[Reaction:R-HSA-5625745] PKN1 stimulates association of AR with NCOA2 - Homo sapiens
[Reaction:R-HSA-5625774] PKN1:AR complex binds promoters of KLK2 and KLK3 genes - Homo sapiens
[Reaction:R-HSA-5625784] PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters - Homo sapiens
[Reaction:R-HSA-5625796] Demethylase KDM4C binds KLK2 and KLK3 promoters - Homo sapiens
[Reaction:R-HSA-5625797] KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters - Homo sapiens
[Reaction:R-HSA-5625849] Demethylase KDM1A binds KLK2 and KLK3 promoters - Homo sapiens
[Reaction:R-HSA-5625848] KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
[Reaction:R-HSA-5625870] KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters - Homo sapiens
[BlackBoxEvent:R-HSA-5625883] PKN1 in complex with AR positively regulates expression of KLK2 and KLK3 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:5625719] A novel inducible transactivation domain in the androgen receptor: implications for PRK in prostate cancer
[LiteratureReference:4687010] LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription
[LiteratureReference:5625775] Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
modified
[InstanceEdit:10901498] Wright, Adam, 2024-03-08
name
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
orthologousEvent
[Pathway:R-DME-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Drosophila melanogaster
[Pathway:R-SCE-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Saccharomyces cerevisiae
[Pathway:R-SPO-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Schizosaccharomyces pombe
[Pathway:R-DDI-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Dictyostelium discoideum
[Pathway:R-GGA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Gallus gallus
[Pathway:R-DRE-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Danio rerio
[Pathway:R-SSC-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Sus scrofa
[Pathway:R-BTA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Bos taurus
[Pathway:R-CFA-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Canis familiaris
[Pathway:R-RNO-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Rattus norvegicus
[Pathway:R-MMU-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 - Mus musculus
releaseDate
2015-03-19
reviewStatus
[ReviewStatus:9821382] five stars
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-5625886
summation
[Summation:5627097] PKN1, activated by phosphorylation at threonine T774, binds ...
Referrals
(hasEvent)
[Pathway:R-HSA-5625740] RHO GTPases activate PKNs
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