Reactome | ARL6:GTP and the BBSome target cargo to the primary cilium

Schema > BlackBoxEvent > Entries

ARL6:GTP and the BBSome target cargo to the primary cilium Show undefined attributes

authored	[InstanceEdit:5623547] Rothfels, Karen, 2014-09-15
category	omitted
compartment	[Compartment:261122] ciliary membrane
created	[InstanceEdit:5624128] Rothfels, Karen, 2014-09-19
dbId	5624127
displayName	ARL6:GTP and the BBSome target cargo to the primary cilium
edited	[InstanceEdit:5626894] Jassal, Bijay, 2014-10-13
eventOf	[Pathway:R-HSA-5620922] BBSome-mediated cargo-targeting to cilium - Homo sapiens
input	[Complex:R-HSA-5624114] ARL6:GTP:BBSome:ciliary cargo [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5623993] Bardet-Biedl syndrome 3 (Bbs3) knockout mouse model reveals common BBS-associated phenotypes and Bbs3 unique phenotypes [LiteratureReference:5618299] The conserved Bardet-Biedl syndrome proteins assemble a coat that traffics membrane proteins to cilia [LiteratureReference:5623983] A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened [LiteratureReference:5624018] Trafficking to the ciliary membrane: how to get across the periciliary diffusion barrier? [LiteratureReference:5618172] The roles of evolutionarily conserved functional modules in cilia-related trafficking
modified	[InstanceEdit:10740525] Wright, Adam, 2024-03-08
name	ARL6:GTP and the BBSome target cargo to the primary cilium
orthologousEvent	[BlackBoxEvent:R-CEL-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Caenorhabditis elegans [BlackBoxEvent:R-GGA-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Gallus gallus [BlackBoxEvent:R-SSC-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Sus scrofa [BlackBoxEvent:R-BTA-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Bos taurus [BlackBoxEvent:R-CFA-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Canis familiaris [BlackBoxEvent:R-RNO-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Rattus norvegicus [BlackBoxEvent:R-MMU-5624127] ARL6:GTP and the BBSome target cargo to the primary cilium - Mus musculus
output	[Complex:R-HSA-5624112] ARL6:GTP:BBSome:ciliary cargo [ciliary membrane]
precedingEvent	[Reaction:R-HSA-5624126] ARL6:GTP and the BBSome bind ciliary cargo - Homo sapiens
regulatedBy	[NegativeRegulation:R-HSA-5624165] Negative regulation by 'LZTFL1 oligomer:BBSome [cytosol]'
regulationReference	[RegulationReference:9642397] Negative regulation by 'LZTFL1 oligomer:BBSome [cytosol]' A novel protein LZTFL1 regulates ciliary trafficking of the BBSome and Smoothened
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5637996] Lorentzen, Esben, 2014-11-10 [InstanceEdit:5638370] Goncalves, Joao, 2014-11-14
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5624127
summation	[Summation:5624033] ARL6:GTP and the BBSome complex are required for the ciliary...
systematicName	ARL6:GTP:BBSome transports BBSome ciliary cargo from plasma membrane to ciliary membrane

Referrals

(hasEvent)

[Pathway:R-HSA-5620922] BBSome-mediated cargo-targeting to cilium