Reactome | ATP hydrolysis by HSP90

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ATP hydrolysis by HSP90 Show undefined attributes

authored	[InstanceEdit:8948984] Shamovsky, Veronica, 2016-11-19
catalystActivity	[CatalystActivity:5618078] ATP hydrolysis activity of HSP90 complexes [nucleoplasm]
category	omitted
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5618086] Shamovsky, Veronica, 2014-08-18
dbId	5618093
displayName	ATP hydrolysis by HSP90
edited	[InstanceEdit:8979349] Shamovsky, Veronica, 2017-02-24
eventOf	[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [DefinedSet:R-HSA-9690535] HSP90 complexes [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8938591] Structure insights into mechanisms of ATP hydrolysis and the activation of human heat-shock protein 90
modified	[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name	ATP hydrolysis by HSP90
orthologousEvent	[BlackBoxEvent:R-DME-5618093] ATP hydrolysis by HSP90 - Drosophila melanogaster [BlackBoxEvent:R-GGA-5618093] ATP hydrolysis by HSP90 - Gallus gallus [BlackBoxEvent:R-SSC-5618093] ATP hydrolysis by HSP90 - Sus scrofa [BlackBoxEvent:R-BTA-5618093] ATP hydrolysis by HSP90 - Bos taurus [BlackBoxEvent:R-RNO-5618093] ATP hydrolysis by HSP90 - Rattus norvegicus [BlackBoxEvent:R-MMU-5618093] ATP hydrolysis by HSP90 - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-HSA-5324621] FKBP4 [nucleoplasm] [DefinedSet:R-HSA-5082395] HSP90:HSP90 [nucleoplasm] [SimpleEntity:R-ALL-113550] Pi [nucleoplasm] 2 × [EntityWithAccessionedSequence:R-HSA-5082403] PTGES3 [nucleoplasm] [DefinedSet:R-HSA-5618077] SHR:SH [nucleoplasm]
precedingEvent	[BlackBoxEvent:R-HSA-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-5618102] Positive regulation by 'SH [cytosol]'
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8939307] Rothfels, Karen, 2016-09-16 [InstanceEdit:8979209] Echeverria, Pablo C, Picard, Didier, 2017-02-22
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-5618093
summation	[Summation:8948955] The chaperoning function of HSP90 is coupled to its ATPase a...

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(hasEvent)

[Pathway:R-HSA-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand