Reactome | MLKL oligomerizes

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MLKL oligomerizes Show undefined attributes

authored	[InstanceEdit:5218858] Shamovsky, V, 2013-12-20
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:5357856] Shamovsky, V, 2014-03-26
dbId	5357927
displayName	MLKL oligomerizes
edited	[InstanceEdit:5673737] Shamovsky, V, 2015-02-09
eventOf	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis - Homo sapiens
followingEvent	[Reaction:R-HSA-5620975] MLKL binds PIPs - Homo sapiens
input	[Complex:R-HSA-5218902] (p-S-RIPK1:p-S199,227-RIPK3) oligomer:4xp-T357,S358-MLKL [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5357933] Plasma membrane translocation of trimerized MLKL protein is required for TNF-induced necroptosis [LiteratureReference:5620989] Mixed lineage kinase domain-like protein MLKL causes necrotic membrane disruption upon phosphorylation by RIP3 [LiteratureReference:9686453] Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [LiteratureReference:9697417] MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	MLKL oligomerizes
output	[Complex:R-HSA-5357794] p-S-RIPK1:p-S199,227-RIPK3:p-T357,S358-MLKL oligomer [cytosol]
precedingEvent	[Reaction:R-HSA-5218906] RIPK3 phosphorylates MLKL - Homo sapiens
regulatedBy	[PositiveRegulation:9692643] Positive regulation by 'p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol]' [NegativeRegulation:9692645] Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]' [PositiveRegulation:9692641] Positive regulation by 'NS1:MLKL [cytosol]'
regulationReference	[RegulationReference:9692644] Positive regulation by 'p-S-RIPK1:p-S199,227-RIPK3 oligomer:4xMLKL:IP6,IP5, IP4 [cytosol]' Direct Activation of Human MLKL by a Select Repertoire of Inositol Phosphate Metabolites [RegulationReference:9692647] Negative regulation by '(p-S-RIPK1:p-S199,227-RIPK3) oligomer:4x(MLKL:ATP) [cytosol]' Conformational switching of the pseudokinase domain promotes human MLKL tetramerization and cell death by necroptosis [RegulationReference:9692642] Positive regulation by 'NS1:MLKL [cytosol]' The NS1 Protein of Influenza A Virus Participates in Necroptosis by Interacting with MLKL and Increasing Its Oligomerization and Membrane Translocation
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633134] Gillespie, Marc E, 2014-10-30 [InstanceEdit:5675023] Chan, Francis Ka-Ming, 2015-02-15 [InstanceEdit:9698846] Murphy, James M, 2020-08-28
schemaClass	Polymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-5357927
summation	[Summation:5357788] Mixed lineage kinase domain-like protein (MLKL) was found to...
systematicName	p-T357,S358-MLKL oligomerizes

Referrals

(precedingEvent)	[Reaction:R-HSA-5620975] MLKL binds PIPs
(hasEvent)	[Pathway:R-HSA-5213460] RIPK1-mediated regulated necrosis

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