Reactome | Depolymerization of lamin filaments after PKC-mediated phosphorylation

Schema > Depolymerisation > Entries

Depolymerization of lamin filaments after PKC-mediated phosphorylation Show undefined attributes

authored	[InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02
catalystActivity	[CatalystActivity:5229188] protein kinase C activity of DAG:active PKC:Ca+2 [nuclear envelope]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:13231] nuclear envelope
created	[InstanceEdit:5229187] Orlic-Milacic, M, 2014-01-16
dbId	5229194
displayName	Depolymerization of lamin filaments after PKC-mediated phosphorylation
edited	[InstanceEdit:5251380] Orlic-Milacic, M, 2014-02-02
eventOf	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina - Homo sapiens
followingEvent	[Reaction:R-HSA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-HSA-2993911] EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:4419965] Mitotic lamin disassembly is triggered by lipid-mediated signaling [LiteratureReference:5229186] Identification of nuclear beta II protein kinase C as a mitotic lamin kinase [LiteratureReference:5229189] Identification of protein kinase C (PKC) phosphorylation sites on human lamin B. Potential role of PKC in nuclear lamina structural dynamics
modified	[InstanceEdit:10486564] Wright, Adam, 2024-03-07
name	Depolymerization of lamin filaments after PKC-mediated phosphorylation
orthologousEvent	[Depolymerisation:R-XTR-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Xenopus tropicalis [Depolymerisation:R-SSC-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Sus scrofa [Depolymerisation:R-BTA-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Bos taurus [Depolymerisation:R-CFA-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Canis familiaris [Depolymerisation:R-RNO-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Rattus norvegicus [Depolymerisation:R-MMU-5229194] Depolymerization of lamin filaments after PKC-mediated phosphorylation - Mus musculus
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [CandidateSet:R-HSA-2993892] EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] [CandidateSet:R-HSA-5229191] p-S395-Lamin dimers [nucleoplasm]
precedingEvent	[Reaction:R-HSA-5223304] DAG and Ca+2 bind to PKC and tether it to membrane - Homo sapiens [Reaction:R-HSA-2993898] VRK1/VRK2 phosphorylate BANF1 - Homo sapiens
releaseDate	2014-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5324613] Gorj�n�cz, M�ty�s, 2014-02-10
schemaClass	Depolymerisation
species	[Species:48887] Homo sapiens
stId	R-HSA-5229194
summation	[Summation:5244775] Protein kinase C (PRKCA and PRKCB), activated by lipin-gener...

Referrals

(precedingEvent)	[Reaction:R-HSA-5244669] CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments
(hasEvent)	[Pathway:R-HSA-4419969] Depolymerization of the Nuclear Lamina