Reactome | AXIN mutants destabilize the destruction complex

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AXIN mutants destabilize the destruction complex Show undefined attributes

authored	[InstanceEdit:4839725] Rothfels, K, 2013-11-01
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:4839736] Rothfels, K, 2013-11-02
dbId	4839734
disease	[Disease:1500689] cancer [Disease:2327993] hepatocellular carcinoma
displayName	AXIN mutants destabilize the destruction complex
edited	[InstanceEdit:5358774] Matthews, Lisa, 2014-04-03
entityFunctionalStatus	[EntityFunctionalStatus:4839737] decreased_transcript_level and loss_of_function of truncation and missense AXIN mutants [cytosol]
eventOf	[Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-1504189] AMER1 [cytosol] [EntityWithAccessionedSequence:R-HSA-195263] CSNK1A1 [cytosol] [EntityWithAccessionedSequence:R-HSA-2997551] GSK3B [cytosol] [EntityWithAccessionedSequence:R-HSA-5246690] K63polyUb-APC [cytosol] [Complex:R-HSA-196206] PP2A [cytosol] [CandidateSet:R-HSA-4839738] truncation and missense AXIN mutants [cytosol]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:5251535] The links between axin and carcinogenesis [LiteratureReference:5251469] AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1 [LiteratureReference:5251510] Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas [LiteratureReference:5251487] Sequence variants of the axin gene in breast, colon, and other cancers: an analysis of mutations that interfere with GSK3 binding [LiteratureReference:5251479] Frequent alterations in the Wnt signaling pathway in colorectal cancer with microsatellite instability
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	AXIN mutants destabilize the destruction complex
normalReaction	[Reaction:R-HSA-195251] Assembly of the destruction complex
releaseDate	2014-06-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5433076] Salahshor, S, 2014-05-12 [InstanceEdit:5545509] Woodgett, Jim, 2014-05-21
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4839734
summation	[Summation:5251523] Alterations in AXIN1 have been detected in a number of diffe...

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[Pathway:R-HSA-5467340] AXIN missense mutants destabilize the destruction complex