Reactome | Defective ALG3 does not add mannose to the N-glycan precursor

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Defective ALG3 does not add mannose to the N-glycan precursor Show undefined attributes

authored	[InstanceEdit:4720494] Jassal, B, 2013-10-21
catalystActivity	[CatalystActivity:9631799] alpha-1,3-mannosyltransferase activity of ALG3 mutants [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:453088] integral component of lumenal side of endoplasmic reticulum membrane
created	[InstanceEdit:4720494] Jassal, B, 2013-10-21
dbId	4720473
disease	[Disease:3781892] congenital disorder of glycosylation type I
displayName	Defective ALG3 does not add mannose to the N-glycan precursor
edited	[InstanceEdit:4720494] Jassal, B, 2013-10-21
entityFunctionalStatus	[EntityFunctionalStatus:4720495] loss_of_function of ALG3 mutants [endoplasmic reticulum membrane]
eventOf	[Pathway:R-HSA-4720475] Defective ALG3 causes CDG-1d - Homo sapiens
input	[SimpleEntity:R-ALL-449298] (GlcNAc)2 (Man)5 (PP-Dol)1 [integral component of lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449229] DOLP-Man [integral component of lumenal side of endoplasmic reticulum membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:4720455] Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase [LiteratureReference:449316] Congenital disorder of glycosylation id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia [LiteratureReference:4720481] CDG-Id in two siblings with partially different phenotypes
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective ALG3 does not add mannose to the N-glycan precursor
normalReaction	[Reaction:R-HSA-446188] ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1
releaseDate	2014-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5633220] Belaya, Katsiaryna, 2014-10-31
schemaClass	FailedReaction
species	[Species:48887] Homo sapiens
stId	R-HSA-4720473
summation	[Summation:4720493] Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransfera...
systematicName	ALG3 mutants do not transfer Man to (GlcNAc)2 (Man)5 (PP-Dol)1

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[Pathway:R-HSA-4720475] Defective ALG3 causes CDG-1d

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