Reactome | AUF1:mRNA complex is destroyed

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AUF1:mRNA complex is destroyed Show undefined attributes

authored	[InstanceEdit:451187] May, B, 2009-12-29
catalystActivity	[CatalystActivity:68824] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:450588] May, B, 2009-12-16
dbId	450466
displayName	AUF1:mRNA complex is destroyed
edited	[InstanceEdit:451187] May, B, 2009-12-29
eventOf	[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA - Homo sapiens
input	[Complex:R-HSA-450458] Ubiquitinated AUF1 Tetramer: Destabilized mRNA Complex [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:451254] Concurrent versus individual binding of HuR and AUF1 to common labile target mRNAs [LiteratureReference:450528] Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs [LiteratureReference:450572] Alternate exon insertion controls selective ubiquitination and degradation of different AUF1 protein isoforms [LiteratureReference:450421] Control of mRNA decay by heat shock-ubiquitin-proteasome pathway
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	AUF1:mRNA complex is destroyed
orthologousEvent	[BlackBoxEvent:R-PFA-450466] AUF1:mRNA complex is destroyed - Plasmodium falciparum [BlackBoxEvent:R-DDI-450466] AUF1:mRNA complex is destroyed - Dictyostelium discoideum [BlackBoxEvent:R-DME-450466] AUF1:mRNA complex is destroyed - Drosophila melanogaster [BlackBoxEvent:R-DRE-450466] AUF1:mRNA complex is destroyed - Danio rerio [BlackBoxEvent:R-SSC-450466] AUF1:mRNA complex is destroyed - Sus scrofa [BlackBoxEvent:R-BTA-450466] AUF1:mRNA complex is destroyed - Bos taurus [BlackBoxEvent:R-CFA-450466] AUF1:mRNA complex is destroyed - Canis familiaris [BlackBoxEvent:R-RNO-450466] AUF1:mRNA complex is destroyed - Rattus norvegicus [BlackBoxEvent:R-MMU-450466] AUF1:mRNA complex is destroyed - Mus musculus
precedingEvent	[BlackBoxEvent:R-HSA-450580] AUF1 (hnRNP D0) is ubiquitinylated - Homo sapiens
releaseDate	2010-09-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:882027] Wilusz, J, 2010-06-29
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-450466
summation	[Summation:451140] Ubiquitin-dependent proteolysis of AUF1 and nuclease-depende...

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[Pathway:R-HSA-450408] AUF1 (hnRNP D0) binds and destabilizes mRNA