Reactome | ATF6 (ATF6-alpha) activates chaperone genes

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ATF6 (ATF6-alpha) activates chaperone genes Show undefined attributes

authored	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
created	[InstanceEdit:381159] May, B, 2008-11-19 16:17:44
dbId	381183
displayName	ATF6 (ATF6-alpha) activates chaperone genes
edited	[InstanceEdit:422550] May, B, 2009-06-02 00:51:49
eventOf	[Pathway:R-HSA-381033] ATF6 (ATF6-alpha) activates chaperones - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:5673197] ATF6-mediated unfolded protein response
hasDiagram	true
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-1791150] Expression of BIP (78 kDa Glucose-regulated protein, GRP78, HSPA5) - Homo sapiens [BlackBoxEvent:R-HSA-1791107] Expression of DDIT3 (CHOP, GADD153) in response to unfolded protein - Homo sapiens [BlackBoxEvent:R-HSA-1791082] Expression of Calreticulin - Homo sapiens [BlackBoxEvent:R-HSA-1791163] Expression of HSP90B1 (Endoplasmin) - Homo sapiens [BlackBoxEvent:R-HSA-1791121] Expression of XBP1(S) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:381018] Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction [LiteratureReference:381102] ATF6 activated by proteolysis binds in the presence of NF-Y (CBF) directly to the cis-acting element responsible for the mammalian unfolded protein response [LiteratureReference:381085] ATF6 as a transcription activator of the endoplasmic reticulum stress element: thapsigargin stress-induced changes and synergistic interactions with NF-Y and YY1 [LiteratureReference:381152] Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response [LiteratureReference:8874816] Transcriptional regulation of secretory capacity by bZip transcription factors [LiteratureReference:8874843] Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response
modified	[InstanceEdit:9847082] Weiser, Joel, 2023-10-12
name	ATF6 (ATF6-alpha) activates chaperone genes
releaseDate	2009-06-24
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 [InstanceEdit:638652] Urano, F, 2010-04-30
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-381183
summation	[Summation:381177] The N-terminal fragment of ATF6-alpha contains a bZIP domain...

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(hasEvent)

[Pathway:R-HSA-381033] ATF6 (ATF6-alpha) activates chaperones