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Schema
>
BlackBoxEvent
>
Entries
APC promotes disassembly of beta-catenin transactivation complex
Show undefined attributes
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authored
[InstanceEdit:3640727] Rothfels, K, 2013-05-29
category
omitted
compartment
[Compartment:7660] nucleoplasm
created
[InstanceEdit:3364043] Rothfels, K, 2013-05-13
dbId
3364042
displayName
APC promotes disassembly of beta-catenin transactivation complex
edited
[InstanceEdit:4655138] Gillespie, ME, 2013-10-02
eventOf
[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex - Homo sapiens
followingEvent
[BlackBoxEvent:R-HSA-3361751] beta-catenin is replaced by repression complexes at the promoter - Homo sapiens
input
[EntityWithAccessionedSequence:R-HSA-3361755] APC [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-3361753] BTRC [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-212372] CTBP1 [nucleoplasm]
[Complex:R-HSA-3361369] TCF/LEF:CTNNB1:BCL9:PYGO:SET1-like complex [nucleoplasm]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:3322328] The APC tumor suppressor counteracts beta-catenin activation and H3K4 methylation at Wnt target genes
[LiteratureReference:3361761] The APC tumor suppressor binds to C-terminal binding protein to divert nuclear beta-catenin from TCF
[LiteratureReference:196262] Crystal structure of a beta-catenin/APC complex reveals a critical role for APC phosphorylation in APC function
[LiteratureReference:3364040] Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex
[LiteratureReference:3364036] Nuclear APC
modified
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name
APC promotes disassembly of beta-catenin transactivation complex
output
[EntityWithAccessionedSequence:R-HSA-1629834] ASH2L [nucleoplasm]
[DefinedSet:R-HSA-3305844] BCL9 [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1183219] KMT2D [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-2186626] MEN1 [nucleoplasm]
[DefinedSet:R-HSA-3322379] PYGO [nucleoplasm]
[EntityWithAccessionedSequence:R-HSA-1629836] RBBP5 [nucleoplasm]
[Complex:R-HSA-3361754] TCF/LEF:CTNNB1:APC:CTBP:BTRC [nucleoplasm]
precedingEvent
[Reaction:R-HSA-3364014] Recruitment of SET1 methyltransferase complex - Homo sapiens
releaseDate
2014-03-12
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:5251465] Rajakulendran, Nishani, 2014-01-22
[InstanceEdit:5323527] van Amerongen, R, 2014-02-14
[InstanceEdit:5368564] Kikuchi, Akira, 2014-04-22
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-3364042
summation
[Summation:3361764] Studies in mouse myoblast and colorectal cancer cell lines s...
Referrals
(hasEvent)
[Pathway:R-HSA-3769402] Deactivation of the beta-catenin transactivating complex
(precedingEvent)
[BlackBoxEvent:R-HSA-3361751] beta-catenin is replaced by repression complexes at the promoter
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